Portal:CPTAC/Hallmarks

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Sustaining proliferative signaling

Hippo-Merlin signaling dysregulation (Homo sapiens)

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Hippo-Merlin signaling dysregulation
Evading growth suppressors

Tumor suppressor activity of SMARCB1 (Homo sapiens)

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Tumor suppressor activity of SMARCB1
Activating invasion and metastasis

Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

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Epithelial to mesenchymal transition in colorectal cancer
Enabling replicative immortality

Notch signaling (Homo sapiens)

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Notch signaling
Inducing angiogenesis

MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors (Homo sapiens)

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MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors
Resisting cell death

Apoptosis (Homo sapiens)

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Apoptosis
Deregulating cellular energetics

Target of rapamycin signaling (Homo sapiens)

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Target of rapamycin signaling
Genome instability and mutation

DNA damage response (only ATM dependent) (Homo sapiens)

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DNA damage response (only ATM dependent)
Tumor promoting inflammation

Cytokines and inflammatory response (Homo sapiens)

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Cytokines and inflammatory response
Avoiding immune destruction

Type II interferon signaling (Homo sapiens)

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Type II interferon signaling