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• Pathway:WP4415
  ... is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).<p>For a review of RUNX2 function, please ... ... ="Reactome">The RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to ...
  388 KB (46676 words) - 16:11, 25 January 2021
• Pathway:WP106
  <Comment Source="WikiPathways-description">Converted from rat to human using ortholog information, originally from KEGG. Originally edit ... ... <Attribute Key="org.pathvisio.model.BackpageHead" Value="ABAT | 4-aminobutyrate aminotransferase" />
  66 KB (6161 words) - 00:15, 30 October 2025
• Pathway:WP244
  ... mportant in signaling events associated with cell growth, survival, and migration under physiological and pathological conditions. ... n to be mechanism of alpha6beta4 induced survival of thymocytes and proliferation of thymic epithelial cells (27,30). Integrin alpha6beta4 is also known ...
  75 KB (7318 words) - 00:20, 30 October 2025
• Pathway:WP179
  <Comment Source="GenMAPP remarks">PCNA; proliferating cell nuclear antigen</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PCNA | proliferating cell nuclear antigen" />
  120 KB (11576 words) - 00:16, 19 August 2025
• Pathway:WP314
  ... <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tum ...
  63 KB (5810 words) - 14:33, 22 November 2025
• Pathway:WP206
  14 KB (1406 words) - 16:26, 22 November 2025
• Pathway:WP306
  ... in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of grow ... <Label TextLabel="Cell proliferation" GraphId="ad9">
  138 KB (13677 words) - 23:15, 29 August 2025
• Pathway:WP195
  ... the AP-1 transcription factor. The above mentioned signaling events co-operatively induce the expression of IL-1 target genes such as CCL2, IL-8 and IL- ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.</Comment>
  99 KB (10551 words) - 09:43, 19 November 2025
• Pathway:WP49
  ... lso activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation ... ... //www.netpath.org/netslim/IL_2_pathway.html) database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab ...
  83 KB (8661 words) - 09:43, 19 November 2025
• Pathway:WP286
  ... 2-associated agonist of cell death (BAD), its binding to 14-3-3 and sequestration into the cytoplasm. IL-3 stimulation activates Janus kinase 2 (JAK2) by ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. &lt;i&gt;Genome Biology&lt;/i&gt;. 11:R3.< ...
  75 KB (7288 words) - 22:57, 30 November 2025
• Pathway:WP395
  ... ncluding asthma, IL-4 was also found to regulate retinal progenitor proliferation, rod photoreceptor differentiation, cholinergic and GABAergic amacrine ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. &lt;i&gt;Genome Biology&lt;/i&gt;. 11:R3.< ...
  105 KB (10802 words) - 12:39, 25 January 2026
• Pathway:WP127
  ... roliferation and differentiation of eosinophils. IL-5 induces terminal maturation of eosinophils, prolongs eosinophils survival by delaying apoptotic dea ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. &lt;i&gt;Genome Biology&lt;/i&gt;. 11:R3.< ...
  70 KB (7129 words) - 23:05, 30 November 2025
• Pathway:WP205
  ... hrough the PI-3 kinase pathway and this effect is required for cell proliferation. IL-7 also induces the phosphorylation of a Src kinase family member, F ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. &lt;i&gt;Genome Biology&lt;/i&gt;. 11:R3.
  48 KB (5195 words) - 23:06, 30 November 2025
• Pathway:WP22
  ... tor of transcription (STAT-1, STAT-3 and STAT-5) and Insulin receptor substrate 1 and 2 (IRS1 and IRS2)/PI3K cascades. IL-9 stimulation also results in t ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. &lt;i&gt;Genome Biology&lt;/i&gt;. 11:R3.< ...
  52 KB (5248 words) - 23:08, 30 November 2025
• Pathway:WP185
  ... Comment Source="GenMAPP remarks">RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)</Comment> ... isio.model.BackpageHead" Value="RAC1 | ras-related C3 botulinum toxin substrate..."/>
  73 KB (7098 words) - 20:25, 26 February 2025
• Pathway:WP382
  ... s cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, ex ... ... isio.model.BackpageHead" Value="RAC2 | ras-related C3 botulinum toxin substrate..." />
  184 KB (17917 words) - 23:00, 29 August 2025
• Pathway:WP368
  ... Key="org.pathvisio.model.BackpageHead" Value="EHHADH | enoyl-Coenzyme A hydratase/3-hydroxya..."/> <Comment Source="GenMAPP remarks">similiar to: ECHA RAT</Comment>
  22 KB (2206 words) - 08:19, 30 November 2025
• Pathway:WP289
  ... he myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gest ... <Attribute Key="org.pathvisio.model.BackpageHead" Value="SFN | stratifin"/>
  119 KB (11692 words) - 22:50, 27 February 2025
• Pathway:WP366
  ... tent-TGF-β-binding proteins. Mature TGF-β isoforms are activated and liberated from extracellular matrix depots by a variety of mechanisms, including p ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3</Comment>
  169 KB (16696 words) - 00:46, 22 May 2024
• Pathway:WP560
  ... y="org.pathvisio.model.BackpageHead" Value="WNT1 | wingless-type MMTV integration site fami..."/> ... ibute Key="org.pathvisio.model.BackpageHead" Value="HRAS | v-Ha-ras Harvey rat sarcoma viral oncoge..."/>
  49 KB (4712 words) - 15:46, 30 January 2026

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