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- Pathway:WP4415 ... is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).<p>For a review of RUNX2 function, please ... ... ="Reactome">The RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to ...388 KB (46676 words) - 16:11, 25 January 2021
- Pathway:WP61 ... ular truncation (NEXT). This is further cleaved by γ-secretase that generates an active Notch intracellular fragment (NIC) or Notch intracellular doma ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. <i>Genome Biology</i>. 11:R3.< ...80 KB (8212 words) - 23:17, 27 February 2025
- Pathway:WP127 ... roliferation and differentiation of eosinophils. IL-5 induces terminal maturation of eosinophils, prolongs eosinophils survival by delaying apoptotic dea ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. <i>Genome Biology</i>. 11:R3.< ...70 KB (7129 words) - 23:05, 30 November 2025
- Pathway:WP364 ... action via the signal transducer gp130 that associates with IL6R in a cooperative manner to form a hexameric signal transducing complex, capable of activ ... ... C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. <i>Genome Biology</i>. 11:R3.89 KB (8624 words) - 23:06, 30 November 2025
- Pathway:WP382 ... s cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, ex ... ... isio.model.BackpageHead" Value="RAC2 | ras-related C3 botulinum toxin substrate..." />184 KB (17917 words) - 23:00, 29 August 2025
- Pathway:WP268 ... raction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD ...29 KB (2841 words) - 23:10, 27 February 2025
- Pathway:WP231 ... Taken together, it has been speculated that RIP1 and RIP3 increase carbohydrate and glutamine metabolism of the cell, leading to increased ROS production ... <Label TextLabel="Golgi apparatus" GraphId="dd6c0">125 KB (12512 words) - 07:33, 5 March 2025
- Pathway:WP497 ... ng birds and most insects, the ammonia is converted into uric acid or its urate salt, which is excreted in solid form. <DataNode TextLabel="Citrate cycle (TCA cycle)" GraphId="e3987" Type="Pathway">61 KB (5848 words) - 06:58, 8 October 2025
- Pathway:WP265 ... .cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kett ... ... title=Pathway:WP61&amp;oldid=20805 WP61(r20805)] with a 94% conversion rate.</Comment>152 KB (12485 words) - 10:16, 23 May 2021
- Pathway:WP493 ... s cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, ex ... ... way:WP382&amp;amp;amp;oldid=28779 WP382(r28779)] with a 91% conversion rate.</Comment>127 KB (12340 words) - 10:32, 23 May 2021
- Pathway:WP29 ... raction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD ...30 KB (3027 words) - 23:06, 20 January 2024
- Pathway:WP199 ... //pathvisio.org/GPML/2013a" Name="Delta-Notch signaling pathway" Organism="Rattus norvegicus"> ... .cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kett ...152 KB (12430 words) - 10:07, 16 May 2021
- Pathway:WP44 ... roliferation and differentiation of eosinophils. IL-5 induces terminal maturation of eosinophils, prolongs eosinophils survival by delaying apoptotic dea ... NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab ...127 KB (10725 words) - 06:07, 18 November 2025
- Pathway:WP358 ... ="http://pathvisio.org/GPML/2013a" Name="MAPK signaling pathway" Organism="Rattus norvegicus" License="CC BY 2.0"> ... s cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, ex ...216 KB (21677 words) - 17:53, 6 July 2025
- Pathway:WP517 ... /2013a" Name="Notch signaling pathway" Last-Modified="2/21/2013" Organism="Rattus norvegicus"> ... way:WP268&amp;amp;amp;oldid=29891 WP268(r29891)] with a 82% conversion rate.</Comment>32 KB (3115 words) - 10:52, 16 May 2021
- Pathway:WP5516 ... tributes to inflammatory bowel disease (IBD), like Crohn's disease and ulcerative colitis. IL23 inhibitors like risankizumab (Skyrizi), guselkumab (Trem ... This signaling pathway primarily promotes the proliferation of Th17 cells, rather than their differentiation, since naive T cells lack IL-23 receptors. T ...44 KB (4640 words) - 11:08, 30 October 2025
- Pathway:WP208 ... raction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD ... <DataNode TextLabel="Serrate" GraphId="c87a5" Type="GeneProduct">17 KB (1685 words) - 05:23, 26 October 2025
- Pathway:WP1214 ... way:WP268&amp;amp;amp;oldid=29891 WP268(r29891)] with a 91% conversion rate.</Comment> ... raction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD ...32 KB (3144 words) - 11:41, 23 May 2021
- Pathway:WP332 ... synthetic pathways. Although there are other biochemical pathways that generate NADPH in yeast, the pentose phosphate pathway is considered the major sou ... ... among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism.</bp:TITLE>31 KB (3266 words) - 08:58, 15 August 2025
- Pathway:WP376 ... http://pathvisio.org/GPML/2013a" Name="Renin-angiotensin system" Organism="Rattus norvegicus"> <Label TextLabel="*Not clear if it also exists in rat" GraphId="bfa67" GroupRef="f4c99">288 KB (39057 words) - 12:35, 31 July 2025
