Non-homologous end joining (Bos taurus)

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Description

Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells. Source: [Wikipedia](http://en.wikipedia.org/wiki/Non-homologous_end_joining).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(80022) with a 91.0% conversion rate.

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Quality Tags

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Bibliography

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History

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CompareRevisionActionTimeUserComment
140247view11:06, 8 August 2025EgonwModified description
80791view15:26, 30 June 2015Mkutmonhomology conversion
63364view22:23, 9 May 2013MaintBotUpdated to 2013 gpml schema
58819view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40536view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35399view09:53, 12 February 2010MartijnVanIerselModified description
33777view00:08, 9 December 2009MaintBotAutomatic update of empty xrefs
33623view10:03, 1 December 2009MaintBotRemoved group label
30548view21:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ligase VGeneProduct
MRE11AGeneProductENSBTAG00000008925 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000020922
NHEJ1GeneProductENSBTAG00000031041 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187736
Nbs1 ?GeneProduct
PRKDCGeneProductENSBTAG00000017019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729
RAD50GeneProductENSBTAG00000011252 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113522
XRCC4GeneProductENSBTAG00000024275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152422
XRCC5GeneProductENSBTAG00000010426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246
XRCC6GeneProductENSBTAG00000006103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419

Annotated Interactions

No annotated interactions
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