Proteasome degradation (Mus musculus)

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Description

Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases. Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Proteasome).

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP183 (r95110) with a 89.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141445view15:18, 14 November 2025DeSlRemoved invisble element
141424view14:30, 13 November 2025Ash iyeradded some of the data annotation for nodes
141391view18:29, 11 November 2025EgonwModified description
117058view14:22, 16 May 2021EweitzModified title
95796view14:41, 19 January 2018MkutmonHomology conversion update
71732view20:17, 17 October 2013MaintBotAutomated update of data sources
71320view17:16, 17 October 2013MaintBotAutomated update of data sources
69110view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67615view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
62832view04:45, 3 May 2013MaintBotUpdated UniProt data source
59032view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41297view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
33047view21:58, 7 October 2009MaintBotAdded xrefs
32452view17:23, 15 August 2009MaintBotFixed text labels
32133view13:56, 14 August 2009MaintBotFixed group labels
31470view21:19, 13 August 2009MaintBotFixed text labels
30910view00:27, 30 July 2009MaintBotConverted from Homo sapiens
21770view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Proteasome Degradation]] moved to [[Pathway:WP519]]: Moved to stable identifier
8350view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Proteasome Degradation]] moved to [[Pathway:Mus musculus:Proteasome Degradation]]: Renaming species
7793view16:18, 18 December 2007MaintBotfixed category names
7486view12:42, 4 November 2007MaintBotAdded categories to GPML
6488view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Proteasome_Degradation]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
Gm21972GeneProductENSMUSG00000094638 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5707
H2-Q10GeneProductENSMUSG00000067235 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3106
H2afxGeneProductENSMUSG00000049932 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3014
H2afzGeneProductENSMUSG00000037894 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3015
HLA-HGeneProduct
HLA-JGeneProduct
Hist1h2anGeneProductENSMUSG00000069309 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8335
IfngGeneProductENSMUSG00000055170 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3458
Nedd4GeneProductENSMUSG00000032216 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4734
Psma1GeneProduct26440 (Entrez Gene) No homologues found for original id L:5682
Psma2GeneProductENSMUSG00000015671 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5683
Psma3GeneProductENSMUSG00000060073 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5684
Psma4GeneProductENSMUSG00000032301 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5685
Psma5GeneProductENSMUSG00000068749 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5686
Psma6GeneProductENSMUSG00000021024 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5687
Psma7GeneProductENSMUSG00000027566 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5688
Psmb10GeneProductENSMUSG00000031897 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5699
Psmb1GeneProductENSMUSG00000014769 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5689
Psmb2GeneProductENSMUSG00000028837 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5690
Psmb3GeneProduct26446 (Entrez Gene) No homologues found for original id L:5691
Psmb4GeneProductENSMUSG00000005779 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5692
Psmb5GeneProductENSMUSG00000022193 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5693
Psmb6GeneProductENSMUSG00000018286 (Ensembl)
  • U13393
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5694
Psmb7GeneProductENSMUSG00000026750 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5695
Psmb8GeneProductENSMUSG00000024338 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5696
Psmb9GeneProductENSMUSG00000096727 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5698
Psmc1GeneProductENSMUSG00000021178 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5700
Psmc2GeneProductENSMUSG00000028932 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5701
Psmc3GeneProductENSMUSG00000002102 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5702
Psmc4GeneProductENSMUSG00000030603 (Ensembl)
  • PRS6 HUMAN
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5704
Psmc5GeneProductENSMUSG00000020708 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5705
Psmc6GeneProductENSMUSG00000021832 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5706
Psmd10GeneProduct53380 (Entrez Gene) No homologues found for original id L:5716
Psmd11GeneProductENSMUSG00000017428 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5717
Psmd12GeneProductENSMUSG00000020720 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5718
Psmd13GeneProductENSMUSG00000025487 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5719
Psmd2GeneProductENSMUSG00000006998 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5708
Psmd3GeneProductENSMUSG00000017221 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5709
Psmd4GeneProductENSMUSG00000005625 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5710
Psmd5GeneProductENSMUSG00000026869 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5711
Psmd6GeneProductENSMUSG00000021737 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9861
Psmd7GeneProductENSMUSG00000039067 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5713
Psmd8GeneProductENSMUSG00000030591 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5714
Psmd9GeneProductENSMUSG00000029440 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5715
Psme1GeneProductENSMUSG00000022216 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5720
Psme2GeneProductENSMUSG00000079197 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5721
Psme3GeneProductENSMUSG00000078652 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10197
Rpn1GeneProductENSMUSG00000030062 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6184
Rpn2GeneProductENSMUSG00000027642 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6185
Uba1GeneProductENSMUSG00000001924 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7317
Uba7GeneProductENSMUSG00000032596 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7318
UbbGeneProductENSMUSG00000019505 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000170315
UbcGeneProduct22190 (Entrez Gene) No homologues found for original id L:7316
Ube2bGeneProductENSMUSG00000020390 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7320
Ube2d1GeneProductENSMUSG00000019927 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7321
Ube2d2aGeneProductENSMUSG00000091896 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7322
Ube2d3GeneProductENSMUSG00000078578 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7323
UbiquitinProteinNo homologues found for original id S:P0CG48
Uchl1GeneProductENSMUSG00000029223 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000154277
Uchl4GeneProductENSMUSG00000035337 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000118939

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP519"
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