Modular map of bradykinin signaling network (Homo sapiens)

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PB-MNC migration via fillopodia formationEndothelium-Derived Hyperpolarizing FactorCell migration in human chondrosarcoma cellsInflammatory and neuropathic painCa2+ independentVasodilatation and plasma leakage at the site of inflammationOsteoclast diffrentiationContraction in human fetal lung fibroblastsATPInflammatory painArachidonic acidCOL1A1SP7P2RY2ACANMMP8MMP13TRPC6NEUROD1MAP1LC3BNOS1TGFB1COL24A1TNFSF11TRPC4NGFMAP1LC3ACREB1BGLAPBECN1CHRM2CHRM3RUNX2ITGA2NFATC1CHRM1TUBB3VEGFASPP1P2RY12DUSP5TNFRSF11B[Des-Arg9]-BradykininIL10ASS1CLCN7GFAPPLATCCN2TRAPCHRM4P2RX6SLC1A1P2RX5VEGFCNEUROG1P2RX7RASA2SOD1CDH5HRASSNOFGF2MMP9MAPK14NHE1MTORPPTGS2IL6CALM1TRPC3FOSRAC1ITGB1MAPK9COL1A1ET-1PANX1PRKCBFGFR1PTRPV1CASP9ANXA1TGFB1TNFCDH1ELK1S383STAT3Y705SRCT416TIMP1MMP9SQSTM1MAPK3Y204T202PTGS2TGFBR2NOTCH1ACTA2MAP2K1PLA2G2ATRPM7MAPK8GNAQJUNS63CLCA4CASP3BAXIKBKBP PTPN6SNOMARCKSS159CLDN5TGFB1KCNN2RELAFOSS276S916PLCB4CCL2SMAD2POSCARSLC1A6KCNMA1MMP2GNB1FOSCCND1RHOAGJA1GTPHSPB1S15S78T143CASP7S82MLC1GNAI1PLCB3CXCL8GNASEGFRS-nitroY1068ROCK1S1047Y1173KDRRAF1PRKCDS338AKT1S473T308MAPTPNFKB1AS32S36TRPA1MAPK1GNA11T185Y187NOS3S1177MYLKGSK3BS9MYH9S1943BCL2PRKD1GNG2S916VIMITGB1CTNNB1 PLD2TRPM8CHUKTRPC1CREB1ACTA2MAP2K2PRKCHPLCG1PXNFRS2PY196CTNNB1 NFKB1RELAB2RB1RPRKCAPRKCECa2+DAGIP3PIK3CBGNAQPTK2PIL1BPLA2G4AVEGFAAngiogenesisTNFNOS3BradykininARRB2NONitric oxide productionROSPIK3CANFKB1InflammationMesenchymal markersCell permeability and migrationAutophagyApoptosisPermeability and cellular junction organizationSTAT3Y705DissociationCa2+ dependentIncrease Neurogenesis and inhibit gliogenesisGlutamate uptakeTransient receptor potential canonical(TRP) channels in the signal transductionContribute to the development of bladder dysfunctionOsteoclast diffrentiation and cellular proliferationReduction in microglial NO productionPTGS1Signal transductionIncreases Ca2+ and PKC activationMARCKSDEPPP2ADominant protein phosphataseActivation of PP2A is unknownDephosphoryaltion by PP2AMMP9MMP2Diabetic nephropathyTranslocation of PKC isozymes fromCytoplasm to membraneIL2LegendB2R induced activationLigandBradykinin[Des-Arg9]-BradykininReceptorB1R induced activationGNG2 and GNB1 mediated activationGNAQ and GNAS mediated activationGNAQ and GNA11 mediated activationLeads to activation through unknown mechanismInhibitionTranslocation Cytoplasm to NucleusCYNUGNAI1 mediated activationTranslocation Cytoplasm to membraneIP3Small moleculemRNAProteinGeneProteinProteinPPhosphorylationProteinSNOS-nitrosylationProteinDEPDephosphorylationUpregulatedDownregulated


Description

A modular map of Bradykinin-mediated inflammatory signaling network

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Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
122841view05:38, 22 May 2022EgonwRemoved Ensembl identifiers that were not valid Ensembl identifiers
120231view11:29, 17 November 2021EweitzModified title
120222view07:12, 15 November 2021EgonwA bit more identifier cleanup
120220view11:25, 14 November 2021EgonwDid some identifier cleanup
120086view15:37, 1 November 2021MkutmonOntology Term : 'signaling pathway' added !
119940view14:25, 25 September 2021EgonwUse Uniprot-TrEMBL
119932view04:14, 23 September 2021Keshav
119916view00:05, 16 September 2021KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
PTPN6GeneProductPTPN6
ACANGeneProductACAN
ACTA2GeneProductACTA2
AKT1GeneProductAKT1
ANXA1GeneProductANXA1
ARRB2GeneProductARRB2
ASS1GeneProductASS1
B1RGeneProductB1R (EcoGene)
B2RGeneProductB2R (EcoGene)
BAXGeneProductBAX
BCL2GeneProductBCL2
BECN1GeneProductBECN1
BGLAPGeneProductBGLAP
BradykininGeneProduct
CALM1GeneProductCALM1
CASP3GeneProductCASP3
CASP7GeneProductCASP7
CASP9GeneProductCASP9
CCL2GeneProductCCL2
CCN2GeneProductCCN2
CCND1GeneProductCCND1
CDH1GeneProductCDH1
CDH5GeneProductCDH5
CHRM1GeneProductCHRM1
CHRM2GeneProductCHRM2
CHRM3GeneProductCHRM3
CHRM4GeneProductCHRM4
CHUKGeneProductCHUK
CLCA4GeneProductCLCA4
CLCN7GeneProductCLCN7
CLDN5GeneProductCLDN5
COL1A1GeneProductCOL1A1
COL24A1GeneProductCOL24A1
CREB1GeneProductCREB1
CTNNB1 GeneProductCTNNB1
CXCL8GeneProductCXCL8
Ca2+GeneProduct
DAGProteinQ14118 (Uniprot-TrEMBL)
DUSP5GeneProductDUSP5
EGFRGeneProductEGFR
ELK1GeneProductELK1
ET-1GeneProductET-1
FGF2GeneProductFGF2
FGFR1GeneProductFGFR1
FOSGeneProductFOS
FRS2GeneProductFRS2
GFAPGeneProductGFAP
GJA1GeneProductGJA1
GNA11ProteinP29992 (Uniprot-TrEMBL)
GNAI1ProteinP63096 (Uniprot-TrEMBL)
GNAQGeneProduct
GNAQGeneProductGNAQ
GNASProteinP63092 (Uniprot-TrEMBL)
GNB1GeneProductGNB1
GNG2GeneProductGNG2
GSK3BGeneProductGSK3B
HRASGeneProductHRAS
HSPB1GeneProductP04792 (Uniprot-TrEMBL)
IKBKBGeneProductIKBKB
IL10GeneProductIL10
IL1BGeneProductIL1B (NCBI Protein)
IL2GeneProduct
IL6GeneProductIL6
IP3GeneProduct
ITGA2GeneProductITGA2
ITGB1GeneProductITGB1
JUNGeneProductJUN
KCNMA1GeneProductKCNMA1
KCNN2GeneProductKCNN2
KDRGeneProductKDR
MAP1LC3AGeneProductMAP1LC3A
MAP1LC3BGeneProductMAP1LC3B
MAP2K1GeneProductMAP2K1
MAP2K2GeneProductMAP2K2
MAPK14GeneProductMAPK14
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProductMAPK1
MAPK8GeneProductMAPK8
MAPK9GeneProductMAPK9
MAPTGeneProductMAPT
MARCKSGeneProductMARCKS
MLC1GeneProductMLC1
MMP13GeneProductMMP13
MMP2GeneProduct
MMP2GeneProductMMP2
MMP8GeneProductMMP8
MMP9GeneProductMMP9
MTORGeneProductMTOR
MYH9GeneProductMYH9
MYLKGeneProductMYLK
NEUROD1GeneProductNEUROD1
NEUROG1GeneProductNEUROG1
NFATC1GeneProductNFATC1
NFKB1AProteinP25963 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NGFGeneProductNGF
NHE1GeneProductNHE1
NOGeneProduct
NOS1GeneProductNOS1
NOS3GeneProductNOS3
NOTCH1GeneProductNOTCH1
OSCARGeneProductOSCAR
P2RX5GeneProductP2RX5
P2RX6GeneProductP2RX6
P2RX7GeneProductP2RX7
P2RY12GeneProductP2RY12
P2RY2GeneProductP2RY2
PANX1GeneProductPANX1
PIK3CAProteinP42336 (Uniprot-TrEMBL)
PIK3CBProteinP42338 (Uniprot-TrEMBL)
PLA2G2AGeneProductPLA2G2A
PLA2G4AGeneProductPLA2G4A (NCBI Protein)
PLATGeneProductPLAT
PLCB3GeneProductPLCB3
PLCB4GeneProductPLCB4
PLCG1GeneProductPLCG1
PLD2ProteinO14939 (Uniprot-TrEMBL)
PP2AGeneProductPP2A
PRKCAGeneProductPRKCA (NCBI Protein)
PRKCBGeneProductPRKCB
PRKCDGeneProductPRKCD
PRKCEGeneProduct
PRKCHGeneProductPRKCH
PRKD1ProteinQ15139 (Uniprot-TrEMBL)
PTGS1GeneProductPTGS1
PTGS2GeneProductPTGS2
PTK2ProteinQ05397 (Uniprot-TrEMBL)
PXNGeneProductPXN
ProteinGeneProduct
RAC1GeneProductRAC1
RAF1GeneProductRAF1
RASA2GeneProductRASA2
RELAGeneProductRELA
RHOAGeneProductRHOA
ROCK1GeneProductROCK1
RUNX2GeneProductRUNX2
SLC1A1GeneProductSLC1A1
SLC1A6GeneProductSLC1A6
SMAD2GeneProductSMAD2
SOD1GeneProductSOD1
SP7GeneProductSP7
SPP1GeneProductSPP1
SQSTM1GeneProductSQSTM1
SRCGeneProductSRC
STAT3GeneProductSTAT3
TGFB1GeneProductTGFB1
TGFBR2GeneProductTGFBR2
TIMP1GeneProductTIMP1
TNFGeneProduct
TNFRSF11BGeneProductTNFRSF11B
TNFSF11GeneProductTNFSF11
TNFGeneProductTNF
TRAPGeneProductTRAP
TRPA1GeneProductTRPA1
TRPC1GeneProductTRPC1
TRPC3GeneProductTRPC3
TRPC4GeneProductTRPC4
TRPC6GeneProductTRPC6
TRPM7GeneProductTRPM7
TRPM8GeneProductTRPM8
TRPV1GeneProductTRPV1
TUBB3GeneProductTUBB3
VEGFAGeneProduct
VEGFAGeneProductVEGFA
VEGFCGeneProductVEGFC
VIMGeneProductVIM
[Des-Arg9]- Bradykinin[Des-Arg9]-Bradykinin
[Des-Arg9]-BradykininGeneProduct
mRNAGeneProduct

Annotated Interactions

No annotated interactions

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