Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms (Homo sapiens)
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Description
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms.
This pathway was created based on figure 2 from Dobrokhotov et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
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Ontology Terms
Saving...Bibliography
- Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
- Dobrokhotov O, Samsonov M, Sokabe M, Hirata H; ''Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms.''; Clin Transl Med, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| ACTA1 | GeneProduct | 58 (Entrez Gene)  | Actin |
| ACTA2 | GeneProduct | 59 (Entrez Gene) | Actin |
| ACTB | GeneProduct | 60 (Entrez Gene) | Actin |
| ACTC1 | GeneProduct | 70 (Entrez Gene) | Actin |
| ACTG1 | GeneProduct | 71 (Entrez Gene) | Actin |
| ACTG2 | GeneProduct | 72 (Entrez Gene) | Actin |
| CDH1 | GeneProduct | 999 (Entrez Gene) | E-cadherin |
| CTNNA1 | GeneProduct | ENSG00000044115 (Ensembl) | |
| CTNNB1 | GeneProduct | ENSG00000168036 (Ensembl) | |
| ITGB1 | GeneProduct | ENSG00000150093 (Ensembl) | |
| ITGB2 | GeneProduct | ENSG00000160255 (Ensembl) | |
| ITGB3 | GeneProduct | ENSG00000259207 (Ensembl) | |
| ITGB4 | GeneProduct | ENSG00000132470 (Ensembl) | |
| ITGB5 | GeneProduct | ENSG00000082781 (Ensembl) | |
| ITGB6 | GeneProduct | ENSG00000115221 (Ensembl) | |
| ITGB7 | GeneProduct | ENSG00000139626 (Ensembl) | |
| ITGB8 | GeneProduct | ENSG00000105855 (Ensembl) | |
| LATS1 | GeneProduct | 9113 (Entrez Gene) | LATS1/2MAP4Ks |
| LIMD1 | GeneProduct | 8994 (Entrez Gene) | LIMD1 |
| MAP4K1 | GeneProduct | ENSG00000104814 (Ensembl) | |
| MAP4K2 | GeneProduct | ENSG00000168067 (Ensembl) | |
| MAP4K3 | GeneProduct | ENSG00000011566 (Ensembl) | |
| MAP4K4 | GeneProduct | ENSG00000071054 (Ensembl) | |
| MAP4K5 | GeneProduct | ENSG00000012983 (Ensembl) | |
| MAPK10 | GeneProduct | 5602 (Entrez Gene) | JNK |
| MAPK8 | GeneProduct | 5599 (Entrez Gene) | JNK |
| MAPK9 | GeneProduct | 5601 (Entrez Gene) | JNK |
| NF2 | GeneProduct | 4771 (Entrez Gene) | Merlin |
| PAK1 | GeneProduct | 5058 (Entrez Gene) | PAK |
| PAK2 | GeneProduct | 5062 (Entrez Gene) | PAK |
| PAK3 | GeneProduct | 5063 (Entrez Gene) | PAK |
| PAK4 | GeneProduct | 10298 (Entrez Gene) | PAK |
| PAK5 | GeneProduct | 57144 (Entrez Gene) | PAK |
| PAK6 | GeneProduct | 56924 (Entrez Gene) | PAK |
| SAV1 | GeneProduct | 60485 (Entrez Gene) | SAV1 |
| SGMS1 | GeneProduct | 259230 (Entrez Gene) | MOB |
| SRC | GeneProduct | 6714 (Entrez Gene) | Src |
| STK3 | GeneProduct | 6788 (Entrez Gene) | MST1/2 |
| STK4 | GeneProduct | 4485 (Entrez Gene) | MST1/2 |
| TEAD1 | GeneProduct | 7003 (Entrez Gene) | TEAD1-4 |
| TEAD2 | GeneProduct | 8463 (Entrez Gene) | TEAD1-4 |
| TEAD3 | GeneProduct | 7005 (Entrez Gene) | TEAD1-4 |
| TEAD4 | GeneProduct | 7004 (Entrez Gene) | TEAD1-4 |
| WWTR1 | GeneProduct | 25937 (Entrez Gene) | YAP/TAZ |
| YAP1 | GeneProduct | 10413 (Entrez Gene) | YAP/TAZ |
| YWHAQ | GeneProduct | 10971 (Entrez Gene) | 14-3-3 |
| a-catenin | GeneProduct |
Annotated Interactions
No annotated interactions
