Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.
View original pathway at Reactome.
Lee AH, Iwakoshi NN, Glimcher LH.; ''XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.''; PubMedEurope PMCScholia
Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD.; ''XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.''; PubMedEurope PMCScholia
Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ.; ''Identification and characterization of a novel member of the EXT gene family, EXTL2.''; PubMedEurope PMCScholia
Saito T, Seki N, Yamauchi M, Tsuji S, Hayashi A, Kozuma S, Hori T.; ''Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.''; PubMedEurope PMCScholia
Yu M, Haslam RH, Haslam DB.; ''HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells.''; PubMedEurope PMCScholia
Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M.; ''Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.''; PubMedEurope PMCScholia
Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, Gibbins JM.; ''A role for the thiol isomerase protein ERP5 in platelet function.''; PubMedEurope PMCScholia
Hayano T, Kikuchi M.; ''Cloning and sequencing of the cDNA encoding human P5.''; PubMedEurope PMCScholia
Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y.; ''Functional analysis of human P5, a protein disulfide isomerase homologue.''; PubMedEurope PMCScholia
Kakiuchi C, Ishiwata M, Hayashi A, Kato T.; ''XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.''; PubMedEurope PMCScholia
Korth MJ, Lyons CN, Wambach M, Katze MG.; ''Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase.''; PubMedEurope PMCScholia
Wise CA, Clines GA, Massa H, Trask BJ, Lovett M.; ''Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family.''; PubMedEurope PMCScholia
Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K.; ''Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.''; PubMedEurope PMCScholia
Li G, Luna C, Qiu J, Epstein DL, Gonzalez P.; ''Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells.''; PubMedEurope PMCScholia
Yoshida H, Oku M, Suzuki M, Mori K.; ''pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.''; PubMedEurope PMCScholia
The EXTL1 gene is transcribed to yield mRNA and the mRNA is translated to yield exostosin-like 1 (EXTL1) protein (Wise et al. 1997, Saito et al. 1998).
The EXTL2 gene is transcribed to yield mRNA and the mRNA is translated to yield exostosin-like 2 (EXTL2) protein (Wuyts et al. 1997, Saito et al. 1998).
Please use the New WikiPathways
View approved pathways at the new wikipathways.org. This website will shutdown soon.Quality Tags
Ontology Terms
Bibliography
History
External references
DataNodes
Annotated Interactions