Serotonin receptor 4/6/7 and NR3C signaling (Bos taurus)

From WikiPathways

Jump to: navigation, search
145, 1553, 71, 76, 100823, 28, 31, 33, 42...44, 457, 13, 24, 35, 55...89, 948, 10, 12, 29, 43...17, 39, 48, 51, 58...664, 9122, 408311, 25, 32, 37, 47...16, 9, 16, 19, 23...38, 9636, 8730, 60, 65, 70, 9750, 7879, 989277, 10188, 934472, 8056, 10520, 5485264, 81, 8667, 7418, 21, 59, 62, 732746, 5214, 41, 49, 75, 90...2Cyclic AMPELK4ADCYHTR7HTR6SRFGR-AMAP2K2BRAFMAPK3HTR4serotoninMAP2K1GNASMAPK1RAP1ACREB1MAPKAPK2ELK1RPS6KRPS6KA5ATF1PKAEGR1


Description

This pathway depicts the downstream signaling of serotonin via receptors 4, 6, and 7, resulting in the activation of EGR1 and NR3C1.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP734(74438) with a 86.0% conversion rate.

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Janknecht R, Hunter T; ''Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.''; EMBO J, 1997 PubMed Europe PMC Scholia
  2. Gupta P, Prywes R; ''ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  3. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, Tamaki T; ''Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  4. Jeon SH, Chae BC, Kim HA, Seo GY, Seo DW, Chun GT, Yie SW, Eom SH, Kim PH; ''The PKA/CREB pathway is closely involved in VEGF expression in mouse macrophages.''; Mol Cells, 2007 PubMed Europe PMC Scholia
  5. Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z; ''ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  6. Hatakeyama M, Yumoto N, Yu X, Shirouzu M, Yokoyama S, Konagaya A; ''Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase.''; Oncogene, 2004 PubMed Europe PMC Scholia
  7. Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S; ''Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  8. Soroka V, Kiryushko D, Novitskaya V, Ronn LC, Poulsen FM, Holm A, Bock E, Berezin V; ''Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  9. Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ; ''cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway.''; Cell, 1997 PubMed Europe PMC Scholia
  10. Enarsson M, Erlandsson A, Larsson H, Forsberg-Nilsson K; ''Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons.''; Mol Cancer Res, 2002 PubMed Europe PMC Scholia
  11. Obara S, Yamada K, Yoshimura Y, Shimoyama M; ''Evidence for the endogenous GTP-dependent ADP-ribosylation of the alpha-subunit of the stimulatory guanyl-nucleotide-binding protein concomitant with an increase in basal adenylyl cyclase activity in chicken spleen cell membrane.''; Eur J Biochem, 1991 PubMed Europe PMC Scholia
  12. Bakovic M, Waite K, Vance DE; ''Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  13. Ryder JW, Fahlman R, Wallberg-Henriksson H, Alessi DR, Krook A, Zierath JR; ''Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  14. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, M�ller M, Gaestel M, Resch K, Holtmann H; ''The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.''; EMBO J, 1999 PubMed Europe PMC Scholia
  15. Gosmanov AR, Wong JA, Thomason DB; ''Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.''; Am J Physiol Cell Physiol, 2002 PubMed Europe PMC Scholia
  16. Hindley A, Kolch W; ''Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  17. Syu LJ, Guan KL, Saltiel AR; ''Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells.''; J Cell Biochem, 1997 PubMed Europe PMC Scholia
  18. Kapoor GS, Golden C, Atkins B, Mehta KD; ''pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells.''; J Lipid Res, 2003 PubMed Europe PMC Scholia
  19. Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, Altruda F, Tarone G, Giancotti FG; ''Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  20. Papin C, Denouel-Galy A, Laugier D, Calothy G, Eych�ne A; ''Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  21. Graf K, Xi XP, Yang D, Fleck E, Hsueh WA, Law RE; ''Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells.''; Hypertension, 1997 PubMed Europe PMC Scholia
  22. New L, Jiang Y, Han J; ''Regulation of PRAK subcellular location by p38 MAP kinases.''; Mol Biol Cell, 2003 PubMed Europe PMC Scholia
  23. Silverman E, Fr�din M, Gammeltoft S, Maller JL; ''Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  24. Tao J, Sanghera JS, Pelech SL, Wong G, Levy JG; ''Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  25. L�pez Bernal A, Rivera J, Europe-Finner GN, Phaneuf S, Asb�th G; ''Parturition: activation of stimulatory pathways or loss of uterine quiescence?''; Adv Exp Med Biol, 1995 PubMed Europe PMC Scholia
  26. Dillon TJ, Karpitski V, Wetzel SA, Parker DC, Shaw AS, Stork PJ; ''Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  27. Hannan RD, Luyken J, Rothblum LI; ''Regulation of rDNA transcription factors during cardiomyocyte hypertrophy induced by adrenergic agents.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  28. Schoenbaum G, Chiba AA, Gallagher M; ''Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning.''; J Neurosci, 1999 PubMed Europe PMC Scholia
  29. Monno S, Newman MV, Cook M, Lowe WL Jr; ''Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.''; Endocrinology, 2000 PubMed Europe PMC Scholia
  30. Yang E, Lerner L, Besser D, Darnell JE Jr; ''Independent and cooperative activation of chromosomal c-fos promoter by STAT3.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  31. Sananbenesi F, Fischer A, Schrick C, Spiess J, Radulovic J; ''Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1.''; Mol Cell Neurosci, 2002 PubMed Europe PMC Scholia
  32. Gao X, Du Z, Patel TB; ''Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  33. Wall NR, Mohammad RM, Al-Katib AM; ''Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.''; Cell Growth Differ, 2001 PubMed Europe PMC Scholia
  34. Berruti G; ''A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells.''; Exp Cell Res, 2000 PubMed Europe PMC Scholia
  35. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; EMBO J, 1995 PubMed Europe PMC Scholia
  36. Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Pr�llage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C; ''Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.''; Eur J Neurosci, 2006 PubMed Europe PMC Scholia
  37. Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, Ishikawa Y; ''Conformation-dependent activation of type II adenylyl cyclase by protein kinase C.''; J Cell Biochem, 1997 PubMed Europe PMC Scholia
  38. Venkatasubbarao K, Choudary A, Freeman JW; ''Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.''; Cancer Res, 2005 PubMed Europe PMC Scholia
  39. Eblen ST, Slack JK, Weber MJ, Catling AD; ''Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  40. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A; ''MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  41. Chen KD, Chen LY, Huang HL, Lieu CH, Chang YN, Chang MD, Lai YK; ''Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  42. Tanimura S, Nomura K, Ozaki K, Tsujimoto M, Kondo T, Kohno M; ''Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  43. Morgan MA, Dolp O, Reuter CW; ''Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.''; Blood, 2001 PubMed Europe PMC Scholia
  44. Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR; ''Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  45. Andressen KW, Norum JH, Levy FO, Krobert KA; ''Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression.''; Mol Pharmacol, 2006 PubMed Europe PMC Scholia
  46. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ; ''Epigenetic programming by maternal behavior.''; Nat Neurosci, 2004 PubMed Europe PMC Scholia
  47. Mitchell J, Bansal A; ''Dexamethasone increases G alpha q-11 expression and hormone-stimulated phospholipase C activity in UMR-106-01 cells.''; Am J Physiol, 1997 PubMed Europe PMC Scholia
  48. Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB; ''Oxidative neuronal injury. The dark side of ERK1/2.''; Eur J Biochem, 2004 PubMed Europe PMC Scholia
  49. Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ; ''FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.''; EMBO J, 1996 PubMed Europe PMC Scholia
  50. Prat AG, Ausiello DA, Cantiello HF; ''Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels.''; Am J Physiol, 1993 PubMed Europe PMC Scholia
  51. Banihashemi B, Albert PR; ''Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia
  52. Szyf M, Weaver IC, Champagne FA, Diorio J, Meaney MJ; ''Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat.''; Front Neuroendocrinol, 2005 PubMed Europe PMC Scholia
  53. Li QJ, Vaingankar S, Sladek FM, Martins-Green M; ''Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.''; Blood, 2000 PubMed Europe PMC Scholia
  54. Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM; ''Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  55. Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, Sturgill TW; ''MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  56. Bading H; ''Transcription-dependent neuronal plasticity the nuclear calcium hypothesis.''; Eur J Biochem, 2000 PubMed Europe PMC Scholia
  57. Yung Y, Yao Z, Aebersold DM, Hanoch T, Seger R; ''Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  58. Papin C, Eych�ne A, Brunet A, Pag�s G, Pouyss�gur J, Calothy G, Barnier JV; ''B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.''; Oncogene, 1995 PubMed Europe PMC Scholia
  59. Singh RP, Tyagi AK, Zhao J, Agarwal R; ''Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis.''; Carcinogenesis, 2002 PubMed Europe PMC Scholia
  60. Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  61. Saji M, Levine MA, Zeiger MA; ''An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.''; Surgery, 1994 PubMed Europe PMC Scholia
  62. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ; ''Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB.''; Biochem Biophys Res Commun, 2004 PubMed Europe PMC Scholia
  63. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV; ''Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  64. Millan MJ, Lejeune F, De Nanteuil G, Gobert A; ''Selective blockade of neurokinin (NK)(1) receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats.''; J Neurochem, 2001 PubMed Europe PMC Scholia
  65. Lum H, Roebuck KA; ''Oxidant stress and endothelial cell dysfunction.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC Scholia
  66. Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M; ''Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.''; Mol Pharmacol, 2002 PubMed Europe PMC Scholia
  67. Casper-Lindley C, Dahlbeck D, Clark ET, Staskawicz BJ; ''Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  68. Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK; ''Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  69. Yan Z, Yang DC, Jett M; ''Cholera toxin induces tumor necrosis factor alpha production in human monocytes.''; Mol Cell Biol Res Commun, 1999 PubMed Europe PMC Scholia
  70. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH; ''TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.''; J Immunol, 1999 PubMed Europe PMC Scholia
  71. Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  72. Duan WR, Ito M, Park Y, Maizels ET, Hunzicker-Dunn M, Jameson JL; ''GnRH regulates early growth response protein 1 transcription through multiple promoter elements.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia
  73. Traub O, Monia BP, Dean NM, Berk BC; ''PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  74. Peters EP, Wilderspin AF, Wood SP, Zvelebil MJ, Sezer O, Danchin A; ''A pyruvate-stimulated adenylate cyclase has a sequence related to the fes/fps oncogenes and to eukaryotic cyclases.''; Mol Microbiol, 1991 PubMed Europe PMC Scholia
  75. Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K; ''Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  76. Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N; ''Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.''; Blood, 2001 PubMed Europe PMC Scholia
  77. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G; ''Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).''; EMBO J, 2003 PubMed Europe PMC Scholia
  78. Chibalin AV, Lopina OD, Petukhov SP, Vasilets LA; ''Phosphorylation of the Na,K-ATPase by Ca,phospholipid-dependent and cAMP-dependent protein kinases. Mapping of the region phosphorylated by Ca,phospholipid-dependent protein kinase.''; J Bioenerg Biomembr, 1993 PubMed Europe PMC Scholia
  79. Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD; ''Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  80. Lee HJ, Mignacca RC, Sakamoto KM; ''Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  81. Ino H, Chiba T; ''Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  82. Rolli M, Kotlyarov A, Sakamoto KM, Gaestel M, Neininger A; ''Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  83. Andrews MH, Kostaki A, Setiawan E, McCabe L, Owen D, Banjanin S, Matthews SG; ''Developmental regulation of the 5-HT7 serotonin receptor and transcription factor NGFI-A in the fetal guinea-pig limbic system: influence of GCs.''; J Physiol, 2004 PubMed Europe PMC Scholia
  84. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, O'Sullivan GC; ''Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  85. Bourdon DM, Camden JM, Landon LA, Levy FO, Turner JT; ''Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular gland.''; Br J Pharmacol, 2000 PubMed Europe PMC Scholia
  86. Sutcliffe JG; ''Open-system approaches to gene expression in the CNS.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  87. Russell DL, Doyle KM, Gonzales-Robayna I, Pipaon C, Richards JS; ''Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1,and early growth response factor-1.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  88. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD; ''Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  89. Hassler M, Richmond TJ; ''The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.''; EMBO J, 2001 PubMed Europe PMC Scholia
  90. Pomerance M, Abdullah HB, Kamerji S, Correze C, Blondeau JP; ''Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  91. Chen JK, Heckert LL; ''Dmrt1 expression is regulated by follicle-stimulating hormone and phorbol esters in postnatal Sertoli cells.''; Endocrinology, 2001 PubMed Europe PMC Scholia
  92. Morrison PF, Morishige GM, Beagles KE, Heyes MP; ''Quinolinic acid is extruded from the brain by a probenecid-sensitive carrier system: a quantitative analysis.''; J Neurochem, 1999 PubMed Europe PMC Scholia
  93. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS; ''Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.''; Endocrinology, 1998 PubMed Europe PMC Scholia
  94. Mo Y, Ho W, Johnston K, Marmorstein R; ''Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.''; J Mol Biol, 2001 PubMed Europe PMC Scholia
  95. Huber-Lang MS, Younkin EM, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Curnutte JT, Erickson R, Ward PA; ''Complement-induced impairment of innate immunity during sepsis.''; J Immunol, 2002 PubMed Europe PMC Scholia
  96. Ravanti L, Heino J, L�pez-Ot�n C, K�h�ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  97. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, Ahn YS; ''Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  98. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M; ''Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  99. Sung JY, Shin SW, Ahn YS, Chung KC; ''Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  100. Vasilevskaya IA, O'Dwyer PJ; ''Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  101. Tokunou T, Ichiki T, Takeda K, Funakoshi Y, Iino N, Takeshita A; ''cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells.''; Arterioscler Thromb Vasc Biol, 2001 PubMed Europe PMC Scholia
  102. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyss�gur J; ''Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.''; EMBO J, 1999 PubMed Europe PMC Scholia
  103. B�langer LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J; ''Mek2 is dispensable for mouse growth and development.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
  104. Azuma N, Akasaka N, Kito H, Ikeda M, Gahtan V, Sasajima T, Sumpio BE; ''Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress.''; Am J Physiol Heart Circ Physiol, 2001 PubMed Europe PMC Scholia
  105. Rossant CJ, Pinnock RD, Hughes J, Hall MD, McNulty S; ''Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3',5'-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  106. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, Chen Q, McLeish KR; ''MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.''; Cell Signal, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125632view01:59, 6 March 2023AlexanderPicoModified description
117603view11:37, 21 May 2021EweitzModified title
101988view06:34, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101982view20:36, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
80922view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCYGeneProductAdenylate cyclase
ATF1GeneProductENSBTAG00000018131 (Ensembl)
  • activating transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
BRAFGeneProductENSBTAG00000021761 (Ensembl)
  • v-raf murine sarcoma viral oncogene homolog B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CREB1GeneProductENSBTAG00000005474 (Ensembl)
  • cAMP response element-binding protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
Cyclic AMPMetabolite60-92-4 (CAS)
EGR1GeneProductENSBTAG00000010069 (Ensembl)
  • early growth response protein
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1958
ELK1GeneProductENSBTAG00000015817 (Ensembl)
  • ELK1, member of ETS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK4GeneProductENSBTAG00000004953 (Ensembl)
  • ETS domain-containing protein Elk-4 (SRF accessory protein 1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
GNASGeneProductENSBTAG00000017475 (Ensembl)
  • GNAS (guanine nucleotide binding protein, alpha stimulating)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GR-AGeneProductENSBTAG00000019472 (Ensembl)
  • nuclear receptor, subfamily 3, group C, member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2908
HTR4GeneProductENSBTAG00000010837 (Ensembl)
  • 5 hydroxytryptamine (serotonin) receptor 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3360
HTR6GeneProductENSBTAG00000007996 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3362
HTR7GeneProductENSBTAG00000008783 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3363
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • mitogen activated protein kinase kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • mitogen activated protein kinase kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • mitogen activated protein kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1
MAPK3GeneProductENSBTAG00000016156 (Ensembl)
  • mitogen activated protein kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl)
  • MAP kinase-activated protein kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
PKAGeneProductcAMP-dependent protein kinase, protein kinase A
RAP1AGeneProductENSBTAG00000014710 (Ensembl)
  • RAS-related protein-1a
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RPS6KGeneProductribosomal protein S6 kinase
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl)
  • ribosomal protein S6 kinase, polypeptide 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
SRFGeneProductENSBTAG00000012777 (Ensembl)
  • serum response factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP3272"
Personal tools