Glutathione metabolism (Bos taurus)

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Description

Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP100)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP100(74146) with a 44.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
142127view07:11, 4 December 2025Khanspers
142126view07:11, 4 December 2025KhanspersModified description
107067view14:15, 17 September 2019MaintBotChEBI identifier normalization
105972view11:50, 16 August 2019MaintBotHMDB identifier normalization
93098view15:31, 28 July 2017DeSlChanged pubchem substance ID to chebi
85646view17:08, 4 June 2016EgonwFixed the KEGG id.
80802view15:26, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(5-L-Glutamyl)-L-amino acidMetaboliteC03740 (KEGG Compound)
1.1.1.43GeneProduct
1.11.1.12GeneProduct
1.5.4.1GeneProduct
1.8.1.13GeneProduct
1.8.3.3GeneProduct
1.8.4.1GeneProduct
1.8.4.2GeneProduct
1.8.4.3GeneProduct
1.8.4.4GeneProduct
1.8.4.7GeneProduct
1.8.5.1GeneProduct
2.3.1.80GeneProduct
2.3.2.4GeneProduct
2.8.1.3GeneProduct
3.4.11.4GeneProduct
3.5.1.78GeneProduct
5-OxoprolineMetaboliteC01879 (KEGG Compound)
6.3.1.8GeneProduct
ANPEPGeneProductENSBTAG00000016881 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:290
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Bis-g-glutamylcystineMetaboliteC03646 (KEGG Compound)
Cysteinyl-glycineMetaboliteC01419 (KEGG Compound)
G6PDGeneProductENSBTAG00000019512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2539
GCLCGeneProductENSBTAG00000015571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
GCLMGeneProductENSBTAG00000007842 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
GGT1GeneProductENSBTAG00000046900 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2678
GGT5GeneProductENSBTAG00000006608 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2687
GPX1GeneProduct
GPX2GeneProductENSBTAG00000048112 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2877
GPX3GeneProductENSBTAG00000043553 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2878
GPX4GeneProductENSBTAG00000046926 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2879
GSRGeneProductENSBTAG00000007115 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2936
GSSGeneProductENSBTAG00000003504 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2937
GSTA1GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000006546;En:ENSBTAG00000006546;
GSTA2GeneProductENSBTAG00000006546 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:221357
GSTM1GeneProduct
GSTM2GeneProduct
GSTT1GeneProduct
GSTT1GeneProductENSBTAG00000040298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2953
Glutamylcysteinyl-glycylspermidineMetabolite440772 (PubChem-compound)
Glutathione (reduced)MetaboliteC00051 (KEGG Compound)
GlycineMetaboliteHMDB0000123 (HMDB)
IDH1GeneProductENSBTAG00000020527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3417
L-Amino acidMetaboliteC00151 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
NADP+MetaboliteHMDB0000217 (HMDB)
NADPHMetaboliteHMDB0000221 (HMDB)
OPLAHGeneProduct
Oxidized glutathioneMetaboliteC00127 (KEGG Compound)
R-S-AlanineMetaboliteC05726 (KEGG Compound)
R-S-AlanylglycineMetaboliteC05729 (KEGG Compound)
R-S-GlutathioneMetaboliteC02320 (KEGG Compound)
R-S-MercapturonateMetaboliteCHEBI:47911 (ChEBI)
g-L-Glutamyl-L-cysteineMetaboliteC00669 (KEGG Compound)

Annotated Interactions

No annotated interactions
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