CYP metabolism of felbamate, with the metabolites 2-hydroxyfelbamate, p-hydroxyfelbamate, and 3-Hydroxy-2-phenylpropylcarbamate. The last further metabolizes to 3-carbamoyl-2-phenylpropionaldehyde, atropaldehyde, and 3-carbamoyl-2-phenylpropionic acid.
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HomologyConvert
This pathway was inferred from Homo sapiens pathway WP2816(76465) with a 66.0% conversion rate.
Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH; ''Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.''; Clin Pharmacokinet, 1997 PubMedEurope PMCScholia
Husain Z, Pinto C, Sofia RD, Yunis EJ; ''Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways.''; Epilepsy Res, 2002 PubMedEurope PMCScholia
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