Hydroxycinnamic acid serotonin amides biosynthesis (Oryza sativa)

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Description

Quality Tags

Ontology Terms

Bibliography

1. Park S, Lee K, Kim YS, Back K.; ''Tryptamine 5-hydroxylase-deficient Sekiguchi rice induces synthesis of 5-hydroxytryptophan and N-acetyltryptamine but decreases melatonin biosynthesis during senescence process of detached leaves.''; PubMed Europe PMC Scholia
2. Fujiwara T, Maisonneuve S, Isshiki M, Mizutani M, Chen L, Wong HL, Kawasaki T, Shimamoto K.; ''Sekiguchi lesion gene encodes a cytochrome P450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice.''; PubMed Europe PMC Scholia
3. Byeon Y, Park S, Kim YS, Park DH, Lee S, Back K.; ''Light-regulated melatonin biosynthesis in rice during the senescence process in detached leaves.''; PubMed Europe PMC Scholia
4. Kang S, Kang K, Lee K, Back K.; ''Characterization of tryptamine 5-hydroxylase and serotonin synthesis in rice plants.''; PubMed Europe PMC Scholia

History

Compare	Revision	Action	Time	User	Comment
	117418	view	10:44, 21 May 2021	Eweitz	Modified title
	82149	view	12:37, 9 September 2015	Anwesha	fixing title, data source, & tagging incomplete pathways
	82051	view	14:41, 8 September 2015	Anwesha	fixing title, data source, & tagging incomplete pathways
	80494	view	14:48, 25 June 2015	Anwesha	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
	Metabolite
(E)-cinnamoyl-CoA	Metabolite	CHEBI:10956 (ChEBI)
4-coumaroyl-CoA	Metabolite	CHEBI:15499 (ChEBI)
5HT	Metabolite	CHEBI:28790 (ChEBI)
CO2	Metabolite	CHEBI:16526 (ChEBI)
CoA-SH	Metabolite	CHEBI:15346 (ChEBI)
H+	Metabolite	CHEBI:15378 (ChEBI)
H2	Metabolite	CHEBI:18276 (ChEBI)
L-Trp	Metabolite	CHEBI:16828 (ChEBI)
NAD(P)+	Metabolite	REACT_20200 (Reactome)
NAD(P)H	Metabolite	REACT_20158 (Reactome)
O2	Metabolite	CHEBI:15379 (ChEBI)
Serotonin N-hydroxycinnamoyltransferase (LOC_OS03G05710.1)	Protein	Q10RP2 (Uniprot-TrEMBL)	Catalyzes the convertion of serotonin into one of four products depending on the other reactants available: caffeoylserotonin, feruloylserotonin, p-coumaroylserotonin or cinnamoylserotonin.
Tryptamine 5-hydroxylase	Protein	1122117 (Reactome)	Catalyzes the convertion of tryptamine into serotonin.
Tryptophan decarboxylase	Protein	1122115 (Reactome)	Catalyzes the convertion of L-tryptophan into tryptamine.
caffeoyl-CoA	Metabolite	CHEBI:15518 (ChEBI)
feruloyl-CoA	Metabolite	CHEBI:15511 (ChEBI)
tryptamine	Metabolite	CHEBI:16765 (ChEBI)

Annotated Interactions

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Source	Target	Type	Database reference	Comment
(E)-cinnamoyl-CoA			1120063 (Reactome)
			1119798 (Reactome)	Serotonin is converted into caffeoylserotonin by enzymatic activity of serotonin N-hydroxycinnamoyltransferase.
			1119839 (Reactome)	Serotonin is converted into feruloylserotonin by enzymatic activity of serotonin N-hydroxycinnamoyltransferase.
			1120063 (Reactome)	Serotonin is converted into cinnamoylserotonin by enzymatic activity of serotonin N-hydroxycinnamoyltransferase.
			1120840 (Reactome)	Serotonin is converted into p-coumaroylserotonin by enzymatic activity of serotonin N-hydroxycinnamoyltransferase.
			1121156 (Reactome)	L-tryptophan is converted into tryptamine by enzymatic activity of aromatic-L-amino-acid decarboxylase.
			1121159 (Reactome)	Tryptamine is converted into serotonin by enzymatic activity of tryptamine 5-hydroxylase.
4-coumaroyl-CoA			1120840 (Reactome)
5HT			1119798 (Reactome)
5HT			1119839 (Reactome)
5HT			1120063 (Reactome)
5HT			1120840 (Reactome)
	5HT	Arrow	1121159 (Reactome)
		Arrow	1119798 (Reactome)
		Arrow	1119839 (Reactome)
		Arrow	1120063 (Reactome)
		Arrow	1120840 (Reactome)
	CO2	Arrow	1121156 (Reactome)
	CoA-SH	Arrow	1119798 (Reactome)
	CoA-SH	Arrow	1119839 (Reactome)
	CoA-SH	Arrow	1120063 (Reactome)
	CoA-SH	Arrow	1120840 (Reactome)
H+			1121159 (Reactome)
	H+	Arrow	1119798 (Reactome)
	H+	Arrow	1119839 (Reactome)
	H+	Arrow	1120063 (Reactome)
	H+	Arrow	1120840 (Reactome)
	H2	Arrow	1121159 (Reactome)
L-Trp			1121156 (Reactome)
	NAD(P)+	Arrow	1121159 (Reactome)
NAD(P)H			1121159 (Reactome)
O2			1121159 (Reactome)
Serotonin N-hydroxycinnamoyltransferase (LOC_OS03G05710.1)		mim-catalysis	1119798 (Reactome)
Serotonin N-hydroxycinnamoyltransferase (LOC_OS03G05710.1)		mim-catalysis	1119839 (Reactome)
Serotonin N-hydroxycinnamoyltransferase (LOC_OS03G05710.1)		mim-catalysis	1120063 (Reactome)
Serotonin N-hydroxycinnamoyltransferase (LOC_OS03G05710.1)		mim-catalysis	1120840 (Reactome)
Tryptamine 5-hydroxylase		mim-catalysis	1121159 (Reactome)
Tryptophan decarboxylase		mim-catalysis	1121156 (Reactome)
caffeoyl-CoA			1119798 (Reactome)
feruloyl-CoA			1119839 (Reactome)
tryptamine			1121159 (Reactome)
	tryptamine	Arrow	1121156 (Reactome)