Arylamine metabolism (Equus caballus)

From WikiPathways

Jump to: navigation, search


Description

Simplified scheme of arylamine metabolism pathway. Arylamines are N-acetylated by NAT2 in the liver, transforming them to relatively nonreactive. Alternatively, they may be N-hydroxylated by CYPIA2, transported to the bladder, and undergo O-acetylation by NATI, to form a highly reactive species.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP694(r29878) with a 63% conversion rate.

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Chou HC, Lang NP, Kadlubar FF; ''Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).''; Cancer Res, 1995 PubMed Europe PMC Scholia
  2. Meyer UA; ''Polymorphism of human acetyltransferases.''; Environ Health Perspect, 1994 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141892view06:25, 26 November 2025EgonwModified description
106095view12:00, 16 August 2019MaintBotHMDB identifier normalization
87003view14:42, 15 July 2016MkutmonOntology Term : 'arylamine metabolic pathway' added !
68739view22:51, 6 July 2013MaintBotUpdated to 2013 gpml schema
58872view00:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
40911view22:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
31820view12:23, 14 August 2009MaintBotFixed group labels
30780view23:29, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
ArylamineMetabolite
Arylamine N,O-sulfateMetabolite
Arylamine N-glucuronideMetabolite
Coenzyme AMetaboliteHMDB0001423 (HMDB)
DeacetylaseGeneProduct
N-AcetylarylamineMetaboliteHMDB0001250 (HMDB)
N-aryl sulfamic acidMetabolite
N-hydroxy-N-acetylamineMetabolite
N-hydroxyarylamineMetabolite
O-acetylarylamineMetabolite
UGT1A4GeneProduct
UGT1A9GeneProduct
XP_001487907.1GeneProductENSECAG00000002652 (Ensembl)
XP_001493936.1GeneProductENSECAG00000008153 (Ensembl)
XP_001502088.1GeneProductENSECAG00000021518 (Ensembl)

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP1211"
Personal tools