Hemoglobin switching: embryonic, fetal, and adult (Homo sapiens)

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Description

The human β-like globin gene cluster is shown together with the five DNase-hypersensitive sites of the locus control region (LCR) super-enhancer. The LCR regulates developmental expression by sequentially interacting with different globin genes during embryonic, fetal, and adult stages. A schematic of the transcription-factor complex that promotes LCR looping to the adult globin genes is also included. Genomic coordinates correspond to the GRCh38 assembly. Inspired by figure 1 in [Vasiloudis et al. 2025](https://pmc.ncbi.nlm.nih.gov/articles/PMC12249674/).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Vasiloudis NI, Paschoudi K, Beta C, Georgolopoulos G, Psatha N; ''Epigenetic Regulation of Erythropoiesis: From Developmental Programs to Therapeutic Targets.''; Int J Mol Sci, 2025 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141580view01:08, 20 November 2025EweitzOntology Term : 'erythrocyte' added !
141579view01:05, 20 November 2025EweitzOntology Term : 'proerythroblast' added !
141578view01:03, 20 November 2025EweitzOntology Term : 'primitive erythroid progenitor' added !
141577view00:57, 20 November 2025EweitzOntology Term : 'erythroid lineage cell' added !
141576view00:56, 20 November 2025EweitzModified description
141575view00:52, 20 November 2025EweitzAdd literature reference
141574view00:38, 20 November 2025EweitzRefine padding
141573view00:36, 20 November 2025EweitzAlign nodes
141571view13:44, 19 November 2025EweitzAdd missing gene identifiers
141570view13:42, 19 November 2025EweitzAdjust container positions
141569view13:40, 19 November 2025EweitzRefine title
141568view13:38, 19 November 2025EweitzAdd NCBI Entrez gene ID for locus control region (LCR)
141567view13:30, 19 November 2025EweitzAdd gene identifiers
141566view13:16, 19 November 2025EweitzAdd database
141551view03:35, 19 November 2025EweitzRefine gene positions in adult stage
141550view03:20, 19 November 2025EweitzFix Kaavio-PathVisio graphical discrepancy
141549view03:19, 19 November 2025EweitzClear cached dimensions
141548view03:17, 19 November 2025EweitzAdd interactions, transcription factor complex
141547view03:04, 19 November 2025EweitzRefine stage labels
141546view02:59, 19 November 2025EweitzAdd adult hemoglobin tetramers
141545view02:38, 19 November 2025EweitzAdd fetal hemoglobin tetramer
141544view02:30, 19 November 2025EweitzAdd stage-specific hemoglobin tetramers
141543view02:11, 19 November 2025EweitzBolden expressed genes
141542view02:10, 19 November 2025EweitzEconomize layout
141541view02:08, 19 November 2025EweitzColor phases
141540view02:01, 19 November 2025EweitzClarify phase delineation
141539view01:57, 19 November 2025EweitzColor genes at top
141538view01:54, 19 November 2025EweitzAdd chromosome and genomic coordinates
141537view01:50, 19 November 2025EweitzFix PathVisio-Kaavio graphical discrepancy
141536view12:24, 18 November 2025EweitzFix PathVisio-Kaavio graphical discrepancy
141526view01:22, 18 November 2025EweitzRefine loops
141525view01:20, 18 November 2025EweitzEconomize layout
141524view01:20, 18 November 2025EweitzEconomize layout
141523view01:20, 18 November 2025EweitzEconomize layout
141522view01:19, 18 November 2025EweitzAdjust chromosome curves
141521view01:18, 18 November 2025EweitzAdjust chromosome curves
141520view01:16, 18 November 2025EweitzFix graphical discrepancy between PathVisio and Kaavio
141519view01:15, 18 November 2025EweitzAdjust adult DNA curve
141518view01:14, 18 November 2025EweitzAdjust adult DNA curve
141517view01:09, 18 November 2025EweitzLabel phases
141516view01:03, 18 November 2025EweitzAdd adult phase
141515view00:48, 18 November 2025EweitzAdd fetal phase
141514view00:40, 18 November 2025EweitzBegin embryonic phase
141504view01:17, 17 November 2025EweitzRefine arrangement, add LCR
141503view12:59, 16 November 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GATA1GeneProductENSG00000102145 (Ensembl)
HBA1GeneProductENSG00000206172 (Ensembl)
HBA2GeneProductENSG00000188536 (Ensembl)
HBBGeneProductENSG00000244734 (Ensembl)
HBDGeneProductENSG00000223609 (Ensembl)
HBE1GeneProductENSG00000213931 (Ensembl)
HBG1GeneProductENSG00000213934 (Ensembl)
HBG2GeneProductENSG00000196565 (Ensembl)
HBZGeneProductENSG00000130656 (Ensembl)
LCR 1GeneProduct109580095 (Entrez Gene)
LCR 2GeneProduct109580095 (Entrez Gene)
LCR 3GeneProduct109580095 (Entrez Gene)
LCR 4GeneProduct109580095 (Entrez Gene)
LCR 5GeneProduct109580095 (Entrez Gene)
LDB1GeneProductENSG00000198728 (Ensembl)
LMO2GeneProductENSG00000135363 (Ensembl)
TAL1GeneProductENSG00000162367 (Ensembl)

Annotated Interactions

No annotated interactions

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