Methylation pathways (Bos taurus)

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Description

This pathway describes the addition of methyl groups to small molecules. SAM, S-Adenosyl methionine, is utilized as a methyl donor and SAH is produced. This process is important in drug metabolism.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP704(79563) with a 88.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
  2. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142034view08:18, 30 November 2025EgonwModified description
117555view11:18, 21 May 2021EweitzModified title
105962view11:49, 16 August 2019MaintBotHMDB identifier normalization
80687view15:22, 30 June 2015Mkutmonhomology conversion
70172view00:40, 13 July 2013AlexanderPicoModified title
63373view23:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
58821view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40545view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33633view10:05, 1 December 2009MaintBotRemoved group label
30561view22:03, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB0000538 (HMDB)
COMTGeneProductENSBTAG00000019516 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000093010
HNMTGeneProductENSBTAG00000014432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150540
INMTGeneProductENSBTAG00000001448 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241644
L-MethionineMetaboliteHMDB0000696 (HMDB)
MAT1AGeneProductENSBTAG00000005963 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151224
MAT2AGeneProductENSBTAG00000020873 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168906
MAT2BGeneProductENSBTAG00000012350 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000038274
N-methylated substrateMetabolite
NNMTGeneProduct
O-methylated substrateMetabolite
PNMTGeneProductENSBTAG00000011731 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141744
PhosphateMetaboliteHMDB0001429 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TPMTGeneProductENSBTAG00000019300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137364

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP992"
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