Dual hijack model of Vif in HIV infection (Homo sapiens)

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1Gene expressionUbiquitin ligationCBFBRBX1CUL5RUNX1ELOBA3GUBBELOCVifCBFBUbE2VifCBFBVif


Description

By hijacking CBF-b, Vif (Viral infectivity factor, HIV protein) is manipulating the ubquitination machinery and adversely effecting host transcriptional regulation.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fraser JS, Gross JD, Krogan NJ; ''From systems to structure: bridging networks and mechanism.''; Mol Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141370view03:58, 11 November 2025EweitzEconomize layout
141369view03:57, 11 November 2025EweitzEconomize layout
137950view19:05, 10 March 2025KhanspersModified description
102277view07:14, 17 December 2018EgonwUpdated Uniprot data source name.
102275view22:50, 16 December 2018Andraupdate vif ids
102274view22:42, 16 December 2018Andraadd uniprot ID
102222view20:56, 11 December 2018KhanspersModified description
102221view20:56, 11 December 2018KhanspersModified description
97835view06:45, 10 June 2018EgonwModified description
97680view13:18, 1 June 2018AMTanOntology Term : 'human immunodeficiency virus infectious disease' added !
87896view12:52, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
85021view19:19, 5 April 2016KhanspersQuick edit to datanode annotation or property
81234view20:25, 6 August 2015Khansperslayout update
81233view19:36, 6 August 2015KhanspersModified description
81232view19:30, 6 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A3GGeneProductENSG00000239713 (Ensembl)
CBFBGeneProductENSG00000067955 (Ensembl)
CUL5GeneProductENSG00000166266 (Ensembl)
E2GeneProductENSG00000067955 (Ensembl)
ELOBGeneProductENSG00000103363 (Ensembl)
ELOCGeneProductENSG00000154582 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
RUNX1GeneProductENSG00000159216 (Ensembl)
UBBGeneProductENSG00000170315 (Ensembl)
VifGeneProduct

Annotated Interactions

No annotated interactions

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