Chromosomal and microsatellite instability in colorectal cancer (Homo sapiens)

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MSI Pathway1-22Colorectal epithelial cellNucleusLegendDefectiveapoptosisActivating mutationLoss of growthinhibitory effects of TGFbSuppressed apoptosisDNA damageTGFBR1TGFB1ApoptosisDCCSMAD4AKT1TP53CASP9SMAD2CASP3PI3KPI3K-Akt Signaling PathwayApoptosisCDKN1ABAXRALAMLH1Wnt signalingTCF7KRASARAFCYCSBIRC5p53 SignalingMAP2K1PMAIP1TGF beta PathwayTGFB2PPPPTGFB3TGFBR2SMAD3PTGFBR2MSH3MSH6BCL2BADBBC3BCL2L11MSH2TCF7L2TCF7L1LEF1MYCCCND1GSK3BAXIN1PAXIN2RALGDSRAF1BRAFAKT2AKT3RALBRAC1RAC2RAC3RHOAMAPK8MAPK9MAPK10MAPK1PMAPK3PJUNFOSPPMYCPBADPMAPKSignalingCell cycleAPPL1CASP9CASP3DDB2POLKBAK1BAXGADD45AGADD45BGADD45GAPCAPC2Anti-apoptosisProliferationUncontrolled proliferationIncreased survivalGenomic instabilityInactivating mutationCSNK1A1LCSNK1A1CTNNB1P


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A; ''Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.''; Pathol Res Pract, 2009 PubMed Europe PMC Scholia
  2. Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD; ''Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.''; J Clin Oncol, 2008 PubMed Europe PMC Scholia
  3. Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K, Saji S; ''Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.''; Gastroenterology, 1996 PubMed Europe PMC Scholia
  4. Miyaki M, Kuroki T; ''Role of Smad4 (DPC4) inactivation in human cancer.''; Biochem Biophys Res Commun, 2003 PubMed Europe PMC Scholia
  5. Pino MS, Chung DC; ''The chromosomal instability pathway in colon cancer.''; Gastroenterology, 2010 PubMed Europe PMC Scholia
  6. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  7. Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A; ''Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.''; Pathol Res Pract, 2009 PubMed Europe PMC Scholia
  8. Mazzoni SM, Fearon ER; ''AXIN1 and AXIN2 variants in gastrointestinal cancers.''; Cancer Lett, 2014 PubMed Europe PMC Scholia
  9. Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD; ''Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.''; J Clin Oncol, 2008 PubMed Europe PMC Scholia
  10. de Miranda NF, van Dinther M, van den Akker BE, van Wezel T, ten Dijke P, Morreau H; ''Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.''; Gastroenterology, 2015 PubMed Europe PMC Scholia
  11. De Bosscher K, Hill CS, Nicolás FJ; ''Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.''; Biochem J, 2004 PubMed Europe PMC Scholia
  12. Koyama M, Ito M, Nagai H, Emi M, Moriyama Y; ''Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.''; Mutat Res, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141103view12:22, 3 November 2025EweitzClear deprecated metadata rendering
137063view23:49, 26 February 2025KhanspersModified description
135166view00:35, 7 August 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
135165view00:35, 7 August 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
135164view00:33, 7 August 2024EweitzRestore state positions
135163view00:29, 7 August 2024EweitzRefine legend
135162view00:25, 7 August 2024EweitzEconomize layout
135161view00:23, 7 August 2024EweitzEconomize layout
134287view05:36, 20 July 2024EgonwRemoved a template comment
128152view16:40, 28 January 2024EweitzImprove alignment
128151view16:14, 28 January 2024EweitzImprove alignment, mitigate truncation
128150view13:18, 28 January 2024EweitzRefine legend
128149view13:09, 28 January 2024EweitzExpand key acronyms, standardize case
127498view18:49, 11 October 2023Khanspersupdated phosphosites for BAD
127314view23:03, 12 September 2023Khanspersupdated phosphosites
127238view20:19, 25 August 2023Khanspersadded lit ref and updated description
123363view05:04, 18 July 2022EgonwMade three pathways clickable
119088view05:27, 17 June 2021Khanspersupdated ptms
108124view10:27, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106356view21:39, 21 August 2019KhanspersModified description
105505view05:57, 8 August 2019KhanspersModified description
103785view20:53, 5 April 2019KhanspersAdded lit refs
97624view08:53, 31 May 2018AMTanOntology Term : 'colorectal cancer' added !
97180view11:48, 4 May 2018EgonwThis interaction is not a mim-conversion.
97139view22:24, 30 April 2018Khanspersupdated lit refs
96883view05:01, 18 April 2018Khanspersupdated layout
96457view11:47, 15 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
96198view19:06, 26 February 2018Khanspersmoved p53 signaling section
96163view01:36, 22 February 2018KhanspersModified description
96162view01:34, 22 February 2018KhanspersCOX-2 reference
96161view01:32, 22 February 2018KhanspersAdded Cox-2 pathway
96156view20:42, 21 February 2018KhanspersAdded information from Pino et al
96147view00:21, 21 February 2018KhanspersModified description
96146view00:10, 21 February 2018KhanspersModified description
96145view00:08, 21 February 2018KhanspersTGFRB2 mutation
96144view00:00, 21 February 2018KhanspersModified description
96143view23:58, 20 February 2018KhanspersKRAS mutation
96142view22:47, 20 February 2018Khanspersmutation information for KRAS
96141view22:41, 20 February 2018KhanspersModified description
96140view22:38, 20 February 2018KhanspersDCC mutation information added as comment
96139view22:30, 20 February 2018Khanspersphosphorylation sites - work in progress
96138view22:00, 20 February 2018Khanspersphosphorylation sites - work in progress
95986view19:23, 12 February 2018KhanspersOntology Term : 'epithelial cell' added !
95985view19:23, 12 February 2018KhanspersOntology Term : 'altered DNA repair pathway' added !
95984view19:22, 12 February 2018KhanspersOntology Term : 'altered Wnt signaling pathway' added !
95983view19:22, 12 February 2018KhanspersOntology Term : 'colorectal cancer pathway' added !
95982view19:21, 12 February 2018KhanspersModified description
95981view19:20, 12 February 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
APPL1GeneProductENSG00000157500 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
AXIN2GeneProductENSG00000168646 (Ensembl)
ApoptosisPathway
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BIRC5GeneProductENSG00000089685 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Cell cyclePathway
DCCGeneProductENSG00000187323 (Ensembl)
DDB2GeneProductENSG00000134574 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAPK SignalingPathway
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MLH1GeneProductENSG00000076242 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MSH3GeneProductENSG00000113318 (Ensembl)
MSH6GeneProductENSG00000116062 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
PI3KGeneProduct
PI3K-Akt Signaling PathwayPathwayWP4172 (WikiPathways)
PMAIP1GeneProductENSG00000141682 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductENSG00000169750 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RALAGeneProductENSG00000006451 (Ensembl)
RALBGeneProductENSG00000144118 (Ensembl)
RALGDSGeneProductENSG00000160271 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TGF beta PathwayPathwayWP366 (WikiPathways)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
Wnt signalingPathway
p53 SignalingPathwayWP1743 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4216"
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