Phosphatidylcholine catabolism (Homo sapiens)

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1Lands Cycle*Membrane transportReceptor-mediated mitogen activityPLDCholineFFAAcyl-CoALyso-PC(/20:4)Lyso-PA(/20:4)sphingomyelinasescholine kinaseGlycerol 3-phosphatesphingomyelinPDEPC(18:0/20:4)betaineacetylcholinePLA1LysoPLA1CoAPA-PLA1Lyso-PCACSStearoyl(18:0) CoAATPFFA(18:0)phosphocholinecPLA2Kennedy pathwayAcyltransferasePA(18:0/20:4)Cell patterning and growthStress responseAAglycerol-phosphocholineLysoPLA2*Lands CycleADP


Description

Schematic representation of phosphatidylcholine catabolism. Formation of various metabolites formed from phosphatidylcholine catabolism, which are signaling molecules.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123457view05:06, 28 July 2022EgonwMade a pathway clickable
101838view16:47, 12 November 2018EgonwReplaced an old Uniprot data source with the new one.
98190view07:26, 3 August 2018EgonwReplaced the CAS number of a salt with a Wikidata of the parent compound.
98157view08:14, 31 July 2018EgonwReplaced the CAS number of a salt with a Wikidata of the parent compound.
96447view09:25, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95593view09:24, 4 January 2018DeSlChnaged layout
95592view09:22, 4 January 2018DeSlAdded last missing identifiers
95591view09:13, 4 January 2018DeSlOntology Term : 'phosphatidylcholine metabolic pathway' added !
95590view09:12, 4 January 2018DeSlOntology Term : 'phosphatidylcholine biosynthetic pathway' added !
95589view09:01, 4 January 2018DeSlAdded wikidata as database source where applicable
95588view08:59, 4 January 2018DeSlAdded more identifiers
95587view08:43, 4 January 2018DeSlAdded several identifiers, and information from text of article which was not in Figure 3
95586view14:25, 3 January 2018DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AAMetaboliteQ407699 (Wikidata) arachidonic acid = AA ?
ACSProtein6.2.1.3 (Enzyme Nomenclature) acyl-CoA synthetase
ADPMetaboliteCHEBI:2342 (ChEBI)
ATPMetaboliteCHEBI:2359 (ChEBI)
Acyl-CoAMetaboliteQ2699537 (Wikidata)
AcyltransferaseProtein2.3.1 (Enzyme Nomenclature)
CholineMetaboliteCHEBI:3665 (ChEBI)
CoAMetaboliteQ407635 (Wikidata)
FFA(18:0)MetaboliteQ209685 (Wikidata)
FFAMetaboliteCHEBI:35366 (ChEBI) Free fatty acids
Glycerol 3-phosphateMetaboliteQ26711901 (Wikidata)
Kennedy pathwayPathwayWP3933 (WikiPathways)
Lyso-PA(/20:4)Metabolite799268-65-8 (CAS)
Lyso-PC(/20:4)Metabolite108341-80-6 (CAS)
Lyso-PCMetaboliteCHEBI:36313 (ChEBI)
LysoPLA1Protein3.1.1.5 (Enzyme Nomenclature) lysophospholipase
LysoPLA2*Protein3.1.1.5 (Enzyme Nomenclature) lysophospholipase
PA(18:0/20:4)Metabolite322647-61-0 (CAS) phosphatidic acid = PA
PA-PLA1ProteinD3K5P3 (Uniprot-SwissProt)
PC(18:0/20:4)Metabolite35418-59-8 (CAS) phosphatidylcholine = PC
PDEProtein3.1.4 (Enzyme Nomenclature) a phosphodiesterase
PLA1Protein3.1.1.32 (Enzyme Nomenclature) phospholipase A1
PLDProtein3.1.4.4 (Enzyme Nomenclature) phospholipase D
Stearoyl(18:0) CoAMetaboliteQ27124612 (Wikidata)
acetylcholineMetaboliteQ180623 (Wikidata)
betaineMetaboliteQ10860583 (Wikidata)
cPLA2Protein3.1.1.4 (Enzyme Nomenclature) phospholipase A2
choline kinaseProtein2.7.1.32 (Enzyme Nomenclature)
glycerol-phosphocholineMetaboliteQ28529699 (Wikidata) In Figure spelled as glycerophosphocholine, in text as glycerol-phosphocholine
phosphocholineMetaboliteCHEBI:295975 (ChEBI)
sphingomyelinMetaboliteCHEBI:17636 (ChEBI)
sphingomyelinasesProtein3.1.4.12 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

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