Somatroph axis (GH) and its relationship to dietary restriction and aging (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Lopez C, Blasco MA, Partridge L, Serrano M, Kroemer G; ''The hallmarks of aging.''; Cell, 2013 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	137495	view	08:21, 3 March 2025	Egonw	Modified description
	135816	view	00:54, 12 November 2024	Eweitz	Fix typo
	123455	view	05:06, 28 July 2022	Egonw	Made a pathway clickable
	105819	view	23:01, 15 August 2019	Khanspers	Modified description
	95479	view	09:12, 18 December 2017	Andra	Connected unconnected line
	95400	view	14:46, 12 December 2017	DeSl	Changed MIM conversion to MIM stimulation for protein-protein interactions.
	95393	view	19:42, 11 December 2017	DeSl	Changed ID for AMPK, spelling correction for lit. reference.
	95392	view	19:36, 11 December 2017	DeSl	Modified description
	95391	view	19:35, 11 December 2017	DeSl	Added literature reference, changed colors.
	95390	view	19:26, 11 December 2017	DeSl	Ontology Term : 'growth factor signaling pathway' added !
	95389	view	19:24, 11 December 2017	DeSl	Ontology Term : 'aging pathway' added !
	95388	view	11:31, 11 December 2017	Rik Lahaije	Modified description
	95387	view	11:26, 11 December 2017	Rik Lahaije	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AKT	GeneProduct	ENSG00000142208 (Ensembl)
AMPK	Metabolite	CHEBI:85053 (ChEBI)
FOXO	GeneProduct	ENSG00000150907 (Ensembl)
GH	Metabolite	CHEBI:37845 (ChEBI)
IGF and insuline signaling	Pathway	WP2799 (WikiPathways)
IGF-1	GeneProduct	ENSG00000140443 (Ensembl)
MTOR	GeneProduct	ENSG00000198793 (Ensembl)
PGC-1 alpha	Protein	Q01711 (Uniprot-TrEMBL)
PI3K	Protein	NP_006209.2 (NCBI Protein)
PTEN	Protein	ENSG00000171862 (Ensembl)
SIRT1	GeneProduct	ENSG00000096717 (Ensembl)

Annotated Interactions

No annotated interactions