Portal:CPTAC
From WikiPathways
CPTAC Pathways
Welcome to the CPTAC Pathway PortalThis portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC). The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public. The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011. | 
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Cancer Hallmark Categories
| Sustaining proliferative signaling
FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (Homo sapiens) Image does not exist FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma | Evading growth suppressors
TGF-beta receptor signaling (Homo sapiens) Image does not exist TGF-beta receptor signaling | Activating invasion and metastasis
H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer (Homo sapiens) Image does not exist H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer |
| Enabling replicative immortality
Notch signaling (Homo sapiens) Image does not exist Notch signaling | Inducing angiogenesis
Hedgehog signaling (Homo sapiens) Image does not exist Hedgehog signaling | Resisting cell death
Target of rapamycin signaling (Homo sapiens) Image does not exist Target of rapamycin signaling |
| Deregulating cellular energetics
Glycolysis and gluconeogenesis (Homo sapiens) Image does not exist Glycolysis and gluconeogenesis | Genome instability and mutation
DNA mismatch repair (Homo sapiens) Image does not exist DNA mismatch repair | Tumor promoting inflammation
IL6 signaling (Homo sapiens) Image does not exist IL6 signaling |
| Avoiding immune destruction
Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens) Image does not exist Altered glycosylation of MUC1 in tumor microenvironment | Therapeutics
Transcriptional activation by NRF2 in response to phytochemicals (Homo sapiens) Image does not exist Transcriptional activation by NRF2 in response to phytochemicals |
Featured Pathways
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Image does not exist PDGFR-beta pathway Zhang, et al. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer |
| View featured pathways |
| List of all pathways for this portal |
Pathway Curation
On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.
Getting Started
- Introduction to WikiPathways (slides)
- WikiPathways Overview or New Contributor Quickstart
- General help pages
- CPTAC Workshop Exercises
Resources
- Learn more about CPTAC
- Pathway analysis
- Cytoscape and the WikiPathways app
- PathVisio and the WikiPathways plugin
Curation projects
- Curating Hallmark Pathways -- How to
- Example: construction of Pathways in Renal Cancer
- Contact Alex Pico if interested in curating, adding or using CPTAC pathways, apico@gladstone.ucsf.edu
