Cannabinoid receptor signaling (Homo sapiens)

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1endogenous cannabinoidsHepG2 cellsLeukocytes, spleen, thymus, bone marrowand other tissues associated with immune functionsInhibition of Glutamate or GABA release in synaptic cleftinactiveNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)NAPEPLDNAPEAEAGABA PhosphatidylethanolamineDAGLBFAAHcAMP GlutamatePKACalciumMAPK 11-OH-THCATPCYP2C9CNR22-arachidonoylglycerolADCY1?CYP2C19ADORA2ACYP1A1OH-CBDsCYP3A4DAGLACBDCOOH-THCprotein tyrosine kinasesAnti-inflammatory pathwaysADCY7THCCNR1AHR37625242PKAATPcAMP


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. ; ''''; http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2,
  2. Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K; ''Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.''; Life Sci, 2011 PubMed Europe PMC Scholia
  3. Yamaori S, Kinugasa Y, Jiang R, Takeda S, Yamamoto I, Watanabe K; ''Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.''; Life Sci, 2015 PubMed Europe PMC Scholia
  4. Díaz-Alonso J, Guzmán M, Galve-Roperh I; ''Endocannabinoids via CB� receptors act as neurogenic niche cues during cortical development.''; Philos Trans R Soc Lond B Biol Sci, 2012 PubMed Europe PMC Scholia
  5. Carrier EJ, Auchampach JA, Hillard CJ; ''Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  6. Anderson GD, Chan LN; ''Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.''; Clin Pharmacokinet, 2016 PubMed Europe PMC Scholia
  7. Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM; ''Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.''; Br J Pharmacol, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141032view13:12, 2 November 2025EweitzClear deprecated metadata rendering
118463view15:04, 27 May 2021FinterlyMoved URL to Source for rdf:id b2b
106148view12:04, 16 August 2019MaintBotHMDB identifier normalization
98007view07:54, 3 July 2018Fehrhartfixed aesthetics
97566view07:39, 25 May 2018IreneHemelModified description
97565view07:39, 25 May 2018IreneHemelModified description
97564view07:36, 25 May 2018IreneHemelAddition of relevant MAPK subtypes
97536view14:31, 24 May 2018IreneHemelSubunits PKA
94926view11:40, 13 October 2017DeSlOntology Term : 'xenobiotic metabolic pathway' added !
94925view11:38, 13 October 2017DeSladded ID for 2nd PKA node
94924view11:37, 13 October 2017DeSladded ID for PKA
94923view11:36, 13 October 2017DeSladded ID for MAPK
88989view11:44, 18 August 2016Mkutmonremoved comments
88980view09:30, 18 August 2016Fehrhartfixed some weird characters
88978view09:18, 18 August 2016Fehrhartadjusted some lines and added descriptions
88975view09:12, 18 August 2016Fehrhartaddition of OH-CBDs
88973view08:36, 18 August 2016FehrhartModified description
88834view13:13, 15 August 2016Fehrhartwork in progress
88833view13:10, 15 August 2016FehrhartModified description
88598view19:51, 11 August 2016Mkutmonfix unconnected lines
88457view14:38, 9 August 2016Fehrhartwork in progress
88450view15:07, 8 August 2016Fehrhartwork in progress
88449view15:02, 8 August 2016Fehrhartadded CYP1A1 stimulation pathway
88389view13:24, 3 August 2016FehrhartOntology Term : 'leukocyte' added !
88388view13:24, 3 August 2016FehrhartOntology Term : 'neuron' added !
88387view13:23, 3 August 2016FehrhartOntology Term : 'cannabinoid signaling pathway' added !
88386view13:22, 3 August 2016FehrhartWork in progress
88383view12:53, 3 August 2016FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-OH-THCMetaboliteHMDB60906 (HMDB)
2-arachidonoylglycerolMetaboliteHMDB04666 (HMDB)
?Metabolite
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADORA2AGeneProductENSG00000128271 (Ensembl)
AEAMetaboliteHMDB04080 (HMDB)
AHRGeneProductENSG00000106546 (Ensembl)
ATPMetaboliteHMDB00538 (HMDB)
Anti-inflammatory pathwaysPathway
CBDMetaboliteCHEBI:69478 (ChEBI)
CNR1GeneProductENSG00000118432 (Ensembl)
CNR2GeneProductENSG00000188822 (Ensembl)
COOH-THCMetaboliteCHEBI:77273 (ChEBI) 22-nor-9-carboxy- D9-tetrahydrocannabinol (COOH-THC) - CheBI Identifier is for11-nor-9-carboxy-Δ9-tetrahydrocannabinol
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CalciumMetaboliteHMDB00464 (HMDB)
DAGLAGeneProductENSG00000134780 (Ensembl)
DAGLBGeneProductENSG00000164535 (Ensembl)
FAAHGeneProductENSG00000117480 (Ensembl)
GABA MetaboliteHMDB00112 (HMDB)
GlutamateMetaboliteHMDB00148 (HMDB)
MAPK GeneProduct
NAPEMetaboliteCHEBI:61232 (ChEBI)
NAPEPLDGeneProductENSG00000161048 (Ensembl)
OH-CBDsMetabolite
  • 6α-OH-, 6β-OH-, 7-OH-, 1″-OH-, 2″-OH-, 3″-OH-, 4″-OH-, and 5″-OH-CBDs
  • no identifier available yet
PKAGeneProduct
PhosphatidylethanolamineMetaboliteHMDB60501 (HMDB)
THCMetaboliteHMDB41865 (HMDB)
cAMP MetaboliteHMDB00058 (HMDB)
protein tyrosine kinasesPathway

Annotated Interactions

No annotated interactions

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