Non-homologous end joining (Danio rerio)

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wu:fa96e12Ku80Ku80Ku80mre11awu:fa96e12Ku80xrcc6RAD50zgc:85657Nbs1 ?xrcc4xrcc6wu:fa96e12zgc:85657Ku80Ku80xrcc6Ku80Ligase Vxrcc6Ku80Ku80xrcc6wu:fa96e12xrcc6Ligase Vwu:fa96e12wu:fa96e12xrcc6wu:fa96e12xrcc6wu:fa96e12xrcc4Ku80xrcc6xrcc6


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 62% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
87943view13:04, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87942view13:04, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
68665view05:22, 6 July 2013MaintBotUpdated to 2013 gpml schema
58795view22:45, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40836view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35406view09:56, 12 February 2010MartijnVanIerselModified description
31916view12:51, 14 August 2009MaintBotFixed group labels
31034view01:15, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ku80GeneProduct
Ligase VGeneProduct
Nbs1 ?GeneProduct
RAD50GeneProduct
mre11aGeneProductENSDARG00000006394 (Ensembl)
wu:fa96e12GeneProductENSDARG00000075083 (Ensembl)
xrcc4GeneProductENSDARG00000010732 (Ensembl)
xrcc6GeneProductENSDARG00000071551 (Ensembl)
zgc:85657GeneProduct406593 (Entrez Gene)
zgc:85657GeneProductENSDARG00000058893 (Ensembl)

Annotated Interactions

No annotated interactions
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