Non-homologous end joining (Anopheles gambiae)

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Ku80Ku70DNA-PKcsKu70Ku70XRCC4Ku70Ku80MRE11AKu80RAD50NHEJ1Nbs1 ?Ku80Ku80Ligase VKu70Ku70Ku80Ku70Ku80DNA-PKcsKu70DNA-PKcsDNA-PKcsKu80Ku70Ligase VDNA-PKcsKu80Ku80DNA-PKcsXRCC4XLFKu70DNA-PKcsDNA-PKcs


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 81% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
87941view13:04, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87939view13:04, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
79418view23:33, 21 March 2015Khanspersupdate schema
79417view23:32, 21 March 2015KhanspersReverted to version '22:59, 20 February 2013' by Khanspers
68437view19:10, 5 July 2013MaintBotUpdated to 2013 gpml schema
58803view22:59, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40468view18:47, 1 March 2011MaintBotRemoved redundant pathway information and comments
35402view09:54, 12 February 2010MartijnVanIerselModified description
31829view12:26, 14 August 2009MaintBotFixed group labels
30791view23:40, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
DNA-PKcsGeneProductAGAP003967 (Ensembl)
Ku70GeneProductAGAP002690 (Ensembl)
Ku80GeneProductAGAP009910 (Ensembl)
Ligase VGeneProduct
MRE11AGeneProductAGAP006797 (Ensembl)
NHEJ1GeneProduct
Nbs1 ?GeneProduct
RAD50GeneProductAGAP003676 (Ensembl)
XLFGeneProduct
XRCC4GeneProduct

Annotated Interactions

No annotated interactions
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