Metastatic brain tumor (Bos taurus)

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123, 4CpG hypermethylationMetastasisDNMTsCDK6E2F3bta-let-7a-1MYCTP53E2H2TTPPIK3R1bta-mir-148abta-mir-34aCDC42MIR29Abta-mir-148bbta-mir-101-1bta-mir-101-2bta-mir-34bbta-mir-34cMIR29B1MIR29B2MIR29Cbta-let-7a-2bta-let-7a-3MIRLET7Bbta-let-7cbta-let-7dbta-let-7ebta-let-7f-1bta-let-7f-2bta-let-7g


Description

Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis.

Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC ,E2F3 and cyclin –dependent kinase(CDK6).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2249(80457) with a 75.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; Cell, 2010 PubMed Europe PMC Scholia
  2. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  3. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
  4. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH; ''p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
89837view12:11, 6 October 2016MkutmonModified description
87810view11:28, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87809view11:28, 25 July 2016ElisaOntology Term : 'disease pathway' added !
80900view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
CDK6GeneProductENSBTAG00000044023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105810
E2F3GeneProductENSBTAG00000021045 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112242
E2H2GeneProduct
MIR29ARna
MIR29B1Rna
MIR29B2Rna
MIR29CRna
MIRLET7BRna
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27986
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
TTPGeneProduct
bta-let-7a-1RnaENSBTAG00000029981 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406881
bta-let-7a-2RnaENSBTAG00000029881 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406882
bta-let-7a-3RnaENSBTAG00000029772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406883
bta-let-7cRnaENSBTAG00000029912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406885
bta-let-7dRnaENSBTAG00000029853 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406886
bta-let-7eRnaENSBTAG00000029880 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406887
bta-let-7f-1RnaENSBTAG00000029935 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406888
bta-let-7f-2RnaENSBTAG00000029774 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406889
bta-let-7gRnaENSBTAG00000029861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406890
bta-mir-101-1RnaENSBTAG00000029855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199135
bta-mir-101-2RnaENSBTAG00000029932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199065
bta-mir-148aRnaENSBTAG00000029945 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199085
bta-mir-148bRnaENSBTAG00000029852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199122
bta-mir-34aRnaENSBTAG00000029924 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207865
bta-mir-34bRnaENSBTAG00000029856 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207811
bta-mir-34cRnaENSBTAG00000029991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562

Annotated Interactions

No annotated interactions
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