Toll-like receptor signaling pathway (Mus musculus)

From WikiPathways

Revision as of 11:16, 25 July 2016 by MirellaKalafati (Talk | contribs)
Jump to: navigation, search
Peptidoglycan(G+)Antiviral effectsLipoarabinomannanDegradation+p+Costimulatory molecules+p+peffectsJak-STAT signaling pathwayeffectsEndosome+p+p+p+p+pbiosynthesis(Neutrophil, immature DC,effectsFlagellar assemblyCytokine-+Chemotactic+pCpG DNAAutocrine / ParacrineMyD88-dependent pathwaycoagulation cascadesUnmethylatedLipoproteinLPS(G-)ApoptosisIKKMyD88-independent pathway+pComplement andZymosan (Yeast)+pssRNA(T cell)NK cell)FlagellinLipopolysaccharideImidazoquinolin+pcytokine receptorInflammatory cytokinesInflammatory cytokinesSpecific pathwayin pDCs+pUbiquitin mediated proteolysis(anti-viral compounds)MAPK signaling pathwaydsRNAChemotactic+p(Mycobacteria)+pProinflammatoryinteractionT cell stimulationNfkb1IFNA14Map2k6Mapk12Myd88Ifnar1Irf5Pik3r1Il12aIFNA13Cd14Cxcl9Irak1Pik3cbJunAkt1Akt2Pik3cdPik3caIFNA17Irf7IkbkeTbk1Tlr2IFNA7Ifnar2Mapk10Cxcl11Tlr6Tlr8Map3k7IFNA2Traf6Tlr7Casp8Map3k7ip1FosIFNA16Irak4Pik3cgIfnb1Nfkb2FaddIl6IL8RelaChukSpp1TirapLbpNfkb1Tlr1Ripk1IFNA8Map2k2Myd88Pik3r5Ifnb1Irf3Mapk13Irak4Mapk1Il1bPik3r2Mapk14Ifnb1Pik3r3NfkbiaMapk11Ccl4TollipIFNA4Il12bTlr2Tlr3TnfCCL3IFNA10Stat1Myd88IFNA6Mapk9Map2k3Ly96Myd88Ticam1Ticam2Cd80Traf6IFNA21Tlr4Cd86Map3k8Rac1TirapChukAkt3Tlr9Cd40Map2k7Map2k4Irak1IkbkgCxcl10IFNA1Map2k1Mapk3Traf6Ccl5IFNA5Mapk8IkbkbTraf3Map3k7ip2Tlr5


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 86% conversion rate.

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
118907view21:51, 3 June 2021EweitzOntology Term : 'Toll-like receptor signaling pathway' added !
118906view21:51, 3 June 2021EweitzOntology Term : 'signaling pathway pertinent to development' added !
114027view15:36, 17 December 2020Fehrhartconnect unconnected lines
107769view18:37, 1 November 2019AgustinGVFix missing Entrez ID
107768view18:35, 1 November 2019AgustinGVFix missing Entrez IDs, remove non orthologues
87795view11:16, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69089view18:11, 8 July 2013MaintBotUpdated to 2013 gpml schema
49294view11:55, 13 July 2012Thomaslinked several interactions
49293view11:53, 13 July 2012Thomaslinked and grouped several genes
41276view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
34381view22:47, 9 December 2009MaintBotAutomatic update of empty xrefs
32299view13:16, 15 August 2009MaintBotFixed text labels
31871view12:38, 14 August 2009MaintBotFixed group labels
31328view20:21, 13 August 2009MaintBotFixed text labels
30898view00:23, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Akt2GeneProduct11652 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Akt3GeneProduct23797 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CCL3GeneProduct20302 (Entrez Gene) Original kegg element: gene;44;hsa:6348
Casp8GeneProduct12370 (Entrez Gene) Original kegg element: gene;87;hsa:841
Ccl4GeneProduct20303 (Entrez Gene) Original kegg element: gene;38;hsa:6351
Ccl5GeneProduct20304 (Entrez Gene) Original kegg element: gene;58;hsa:6352
Cd14GeneProduct12475 (Entrez Gene) Original kegg element: gene;84;hsa:929
Cd40GeneProduct21939 (Entrez Gene) Original kegg element: gene;29;hsa:958
Cd80GeneProduct12519 (Entrez Gene) Original kegg element: gene;69;hsa:941
Cd86GeneProduct12524 (Entrez Gene) Original kegg element: gene;28;hsa:942
ChukGeneProduct12675 (Entrez Gene) Original kegg element: gene;42;hsa:1147
Cxcl10GeneProduct15945 (Entrez Gene) Original kegg element: gene;25;hsa:3627
Cxcl11GeneProduct56066 (Entrez Gene) Original kegg element: gene;23;hsa:6373
Cxcl9GeneProduct17329 (Entrez Gene) Original kegg element: gene;24;hsa:4283
FaddGeneProduct14082 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FosGeneProduct14281 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProduct110296 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct15962 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct230396 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProduct404549 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct15965 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct15967 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct15968 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct15969 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct15970 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IL8GeneProductOriginal kegg element: gene;43;hsa:3576
Ifnar1GeneProduct15975 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
Ifnar2GeneProduct15976 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
Ifnb1GeneProduct15977 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IkbkbGeneProduct16150 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IkbkeGeneProduct56489 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IkbkgGeneProduct16151 (Entrez Gene) Original kegg element: gene;85;hsa:8517
Il12aGeneProduct16159 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
Il12bGeneProduct16160 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
Il1bGeneProduct16176 (Entrez Gene) Original kegg element: gene;51;hsa:3553
Il6GeneProduct16193 (Entrez Gene) Original kegg element: gene;57;hsa:3569
Irak1GeneProduct16179 (Entrez Gene) Original kegg element: gene;41;hsa:3654
Irak4GeneProduct266632 (Entrez Gene) Original kegg element: gene;86;hsa:51135
Irf3GeneProduct54131 (Entrez Gene) Original kegg element: gene;67;hsa:3661
Irf5GeneProduct27056 (Entrez Gene) Original kegg element: gene;21;hsa:3663
Irf7GeneProduct54123 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JunGeneProduct16476 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LbpGeneProduct16803 (Entrez Gene) Original kegg element: gene;77;hsa:3929
Ly96GeneProduct17087 (Entrez Gene) Original kegg element: gene;71;hsa:23643
Map2k1GeneProduct26395 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
Map2k2GeneProduct26396 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
Map2k3GeneProduct26397 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
Map2k4GeneProduct26398 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
Map2k6GeneProduct26399 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
Map2k7GeneProduct26400 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
Map3k7GeneProduct26409 (Entrez Gene) Original kegg element: gene;37;hsa:6885
Map3k7ip1GeneProduct66513 (Entrez Gene) Original kegg element: gene;59;hsa:10454
Map3k7ip2GeneProduct68652 (Entrez Gene) Original kegg element: gene;61;hsa:23118
Map3k8GeneProduct26410 (Entrez Gene) Original kegg element: gene;13;hsa:1326
Mapk10GeneProduct26414 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Mapk11GeneProduct19094 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk12GeneProduct29857 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk1GeneProduct26413 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
Mapk13GeneProduct26415 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk14GeneProduct26416 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk3GeneProduct26417 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
Mapk8GeneProduct26419 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Mapk9GeneProduct26420 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Myd88GeneProduct17874 (Entrez Gene) Original kegg element: gene;47;hsa:4615
Nfkb1GeneProduct18033 (Entrez Gene) Original kegg element: gene;14;hsa:4790
Nfkb2GeneProduct18034 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NfkbiaGeneProduct18035 (Entrez Gene) Original kegg element: gene;64;hsa:4792
Pik3caGeneProduct18706 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cbGeneProduct74769 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cdGeneProduct18707 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cgGeneProduct30955 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r1GeneProduct18708 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r2GeneProduct18709 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r3GeneProduct18710 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r5GeneProduct320207 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Rac1GeneProduct19353 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RelaGeneProduct19697 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
Ripk1GeneProduct19766 (Entrez Gene) Original kegg element: gene;17;hsa:8737
Spp1GeneProduct20750 (Entrez Gene) Original kegg element: gene;15;hsa:6696
Stat1GeneProduct20846 (Entrez Gene) Original kegg element: gene;62;hsa:6772
Tbk1GeneProduct56480 (Entrez Gene) Original kegg element: gene;52;hsa:29110
Ticam1GeneProduct106759 (Entrez Gene) Original kegg element: gene;82;hsa:148022
Ticam2GeneProduct225471 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TirapGeneProduct117149 (Entrez Gene) Original kegg element: gene;83;hsa:114609
Tlr1GeneProduct21897 (Entrez Gene) Original kegg element: gene;75;hsa:7096
Tlr2GeneProduct24088 (Entrez Gene) Original kegg element: gene;74;hsa:7097
Tlr3GeneProduct142980 (Entrez Gene) Original kegg element: gene;73;hsa:7098
Tlr4GeneProduct21898 (Entrez Gene) Original kegg element: gene;79;hsa:7099
Tlr5GeneProduct53791 (Entrez Gene) Original kegg element: gene;72;hsa:7100
Tlr6GeneProduct21899 (Entrez Gene) Original kegg element: gene;76;hsa:10333
Tlr7GeneProduct170743 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
Tlr8GeneProduct170744 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
Tlr9GeneProduct81897 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TnfGeneProduct21926 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TollipGeneProduct54473 (Entrez Gene) Original kegg element: gene;81;hsa:54472
Traf3GeneProduct22031 (Entrez Gene) Original kegg element: gene;16;hsa:7187
Traf6GeneProduct22034 (Entrez Gene) Original kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP1271"