Regulation of Wnt / B-catenin signaling by small molecule compounds (Homo sapiens)

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1Gene Transcription RegulationTCF4GlucocorticoidsFZD AntibodiesWnt AntibodiesPRK118-744IWP-2PyrviniumFZD7PRK222-815ICG-001V3nterGSK3BiCRT5DKK3PRK115-5841a,25-(OH)2D3 PRK118-310XAV939iCRT14WNTFZDTNKSCatenin beta-1LRPFZD8iCRT3DVL2NC043LEF1IC261CK1aAPCCGP049090DVL PDZ DomainsRetinoidsNSC668036MBOATCK1eSFRP4AXIN1


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. White BD, Chien AJ, Dawson DW; ''Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers.''; Gastroenterology, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139127view03:21, 22 May 2025EweitzClear dimension cache
139126view03:21, 22 May 2025EweitzEconomize layout
139125view02:55, 22 May 2025EweitzUse gene symbols
139124view02:52, 22 May 2025EweitzFix PathVisio / Kaavio graphical discrepancy
139123view02:52, 22 May 2025EweitzStandardize case, refine cell layering
139122view02:50, 22 May 2025EweitzFix truncated text by enlarging state
139058view04:36, 17 May 2025KhanspersIncrease font size, update layout
137135view23:12, 27 February 2025KhanspersModified description
118061view10:37, 24 May 2021EweitzModified title
111245view09:49, 27 July 2020MelodynerOntology Term : 'growth factor signaling pathway' added !
107145view14:23, 17 September 2019MaintBotChEBI identifier normalization
106496view21:44, 4 September 2019KhanspersModified description
105519view06:55, 8 August 2019KhanspersModified description
94746view15:14, 5 October 2017Mkutmonfix unconnected line
93253view09:18, 9 August 2017DeSlRemoved comment for node NC043
93252view09:17, 9 August 2017DeSlChanged ID of NC043 from INCHI to CAS.
93245view11:40, 8 August 2017DeSlChanged ID of 1a,25-(OH)2D3 to more stereospeific one; added 2 metabolite IDs which were previously not found.
93087view13:32, 28 July 2017DeSlChnaged all pubchem substance IDs to more stereospecified IDs
90182view18:19, 21 October 2016Khanspersfixed unconnected
90083view05:35, 13 October 2016KhanspersModified title
90082view05:34, 13 October 2016Khansperscleanup
88608view22:50, 11 August 2016AAR&CoOntology Term : 'gastrointestinal carcinoma' added !
88607view22:37, 11 August 2016AAR&CoPeriodical save, work in progress
88606view22:17, 11 August 2016AAR&CoPeriodical save, work in progress
87635view08:54, 25 July 2016LindarieswijkOntology Term : 'altered Wnt signaling pathway' added !
85938view18:54, 21 June 2016AAR&CoAdjust Interactions
85937view18:51, 21 June 2016AAR&CoAdjust Interactions to Wnt
85935view18:35, 21 June 2016AAR&CoFixed Unconnected Lines
85934view18:32, 21 June 2016AAR&CoModified description
85873view15:14, 19 June 2016AAR&CoModified description
85872view15:05, 19 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1a,25-(OH)2D3 Metabolite13019066 (PubChem-compound)
APCGeneProductENSG00000134982 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
CGP049090MetaboliteIdentifier Not Found
CK1aGeneProduct1452 (NCBI Protein)
CK1eGeneProduct1454 (NCBI Protein)
Catenin beta-1ProteinB4DGU4 (Uniprot-TrEMBL)
DKK3GeneProductENSG00000050165 (Ensembl)
DVL PDZ DomainsGeneProductGeneral Term
DVL2GeneProductENSG00000004975 (Ensembl)
FZD AntibodiesGeneProductGeneral Term
FZD7GeneProductENSG00000155760 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
FZDGeneProductFZD1 (HGNC) FZD Not Specified
GSK3BGeneProductENSG00000082701 (Ensembl)
GlucocorticoidsMetabolite53787563 (PubChem-substance)
IC261Metabolite53789627 (PubChem-substance)
ICG-001Metabolite136340203 (PubChem-substance)
IWP-2Metabolite2155128 (PubChem-compound)
LEF1GeneProductENSG00000138795 (Ensembl)
LRPGeneProductENSG00000123384 (Ensembl) LRP Not Specified
MBOATGeneProductENSG00000172197 (Ensembl) MBOAT Family
NC043MetaboliteIdentifer Not Found
NSC668036Metabolite76620423 (PubChem-substance)
PRK115-584MetaboliteIdentifier Not Found
PRK118-310MetaboliteIdentifier Not Found
PRK118-744MetaboliteIdentifier Not Found
PRK222-815MetaboliteIdentifier Not Found
PyrviniumMetabolite123097016 (PubChem-substance)
RetinoidsMetabolite135307150 (PubChem-substance)
SFRP4GeneProductENSG00000106483 (Ensembl)
TCF4GeneProductENSG00000196628 (Ensembl)
TNKSGeneProductENSG00000173273 (Ensembl)
V3nterGeneProductIdentifier not found
WNTGeneProductENSG00000125084 (Ensembl) Wnt Not Specified
Wnt AntibodiesGeneProductGeneral Term
XAV939Metabolite254760594 (PubChem-substance)
iCRT14Metabolite162247440 (PubChem-substance)
iCRT3Metabolite275174963 (PubChem-substance)
iCRT5Metabolite164227414 (PubChem-substance)

Annotated Interactions

No annotated interactions

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