NAD metabolism, sirtuins and aging (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Verdin E; ''NAD⁺ in aging, metabolism, and neurodegeneration.''; Science, 2015 PubMed Europe PMC Scholia
2. Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P; ''Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage.''; Cell Cycle, 2006 PubMed Europe PMC Scholia
3. Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Birukov KG, Samant S, Hottiger MO, Gupta MP; ''SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	138896	view	00:18, 7 May 2025	Eweitz	Ontology Term : 'ataxia telangiectasia' added !
	138895	view	00:18, 7 May 2025	Eweitz	Ontology Term : 'xeroderma pigmentosum' added !
	138894	view	00:18, 7 May 2025	Eweitz	Ontology Term : 'Cockayne syndrome' added !
	137771	view	01:00, 8 March 2025	Khanspers	Modified description
	128523	view	14:27, 11 February 2024	Eweitz	Nudge text into alignment
	128522	view	02:42, 11 February 2024	Eweitz	Upgrade disease nodes
	128521	view	01:28, 11 February 2024	Eweitz	Economize layout, refine legend, standardize case
	121716	view	14:03, 26 February 2022	Eweitz	Use gene symbol
	118942	view	22:32, 4 June 2021	Eweitz	Ontology Term : 'aging pathway' added !
	118941	view	22:32, 4 June 2021	Eweitz	Ontology Term : 'Sirtuin mediated pathway' added !
	106745	view	13:22, 17 September 2019	MaintBot	HMDB identifier normalization
	106655	view	21:16, 12 September 2019	Khanspers	Modified description
	105656	view	05:15, 10 August 2019	Khanspers	Modified description
	94184	view	13:55, 25 August 2017	Mkutmon	added missing metabolite identifier
	92696	view	19:24, 28 June 2017	Mkutmon	removed undefined xref
	88178	view	16:25, 29 July 2016	Jmelius	Ontology Term : 'classic metabolic pathway' added !
	85545	view	23:30, 27 May 2016	AlexanderPico	Updated layout and groupings
	85544	view	23:17, 27 May 2016	AlexanderPico	Quick edit to datanode annotation or property
	85530	view	18:53, 26 May 2016	Khanspers	fixed unconnected interactions
	85439	view	20:40, 15 May 2016	Susan	Quick edit to datanode annotation or property
	85406	view	05:09, 13 May 2016	Khanspers	interactions
	85394	view	05:35, 12 May 2016	Khanspers	layout
	85393	view	05:32, 12 May 2016	Khanspers	added literature references
	85392	view	18:32, 11 May 2016	Khanspers	update to interactions
	85236	view	23:18, 3 May 2016	Khanspers	added identifier to reservatrol
	85235	view	23:10, 3 May 2016	Khanspers	Modified description
	85234	view	23:07, 3 May 2016	Khanspers	overhaul
	85231	view	04:59, 3 May 2016	Khanspers	Modified description
	85230	view	04:57, 3 May 2016	Khanspers	Modified description
	85227	view	20:08, 2 May 2016	Khanspers	rearrange
	84991	view	20:35, 4 April 2016	Khanspers	Periodical save, work in progress
	84988	view	20:25, 4 April 2016	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
FOXO1	GeneProduct	ENSG00000150907 (Ensembl)
FOXO3	GeneProduct	ENSG00000118689 (Ensembl)
HIF1A	GeneProduct	ENSG00000100644 (Ensembl)
NAD	Metabolite	HMDB00902 (HMDB)
NAMPT	GeneProduct	ENSG00000105835 (Ensembl)
NF-kB	GeneProduct
Nicotinamide riboside	Metabolite	HMDB00855 (HMDB)
PARP1	GeneProduct	ENSG00000143799 (Ensembl)
PGC-1a	GeneProduct	ENSG00000108064 (Ensembl)
PPARG	GeneProduct	ENSG00000132170 (Ensembl)
PRORY	GeneProduct	ENSG00000183146 (Ensembl)
ROS1	GeneProduct	ENSG00000047936 (Ensembl)
Reservatrol	Metabolite
SIRT1	GeneProduct	ENSG00000096717 (Ensembl)
SIRT3	GeneProduct	ENSG00000142082 (Ensembl)
SIRT5	GeneProduct	ENSG00000124523 (Ensembl)
TFAM	GeneProduct	ENSG00000108064 (Ensembl)
TORC2	GeneProduct	ENSG00000108064 (Ensembl)

Annotated Interactions

No annotated interactions