Demo_complete (Homo sapiens)
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Description
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics.
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Ontology Terms
Saving...Bibliography
- Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Cholesterol ester | Metabolite | C02530 (KEGG Compound)  | |
| Cholesterol | Metabolite | HMDB00067 (HMDB) | |
| FDFT1 | GeneProduct | ENSG00000079459 (Ensembl) | |
| HMG-CoA | Metabolite | HMDB01375 (HMDB) | |
| HMGCR | GeneProduct | ENSG00000113161 (Ensembl) | |
| MTTP | GeneProduct | ENSG00000138823 (Ensembl) | |
| Mevalonate | Metabolite | HMDB59629 (HMDB) | |
| PDIA2 | GeneProduct | ENSG00000185615 (Ensembl) | |
| SOAT1 | GeneProduct | ENSG00000057252 (Ensembl) | |
| SQLE | GeneProduct | ENSG00000104549 (Ensembl) | |
| Squalene | Metabolite | HMDB00256 (HMDB) | |
| Statin | Metabolite | HMDB05022 (HMDB) |
Annotated Interactions
No annotated interactions
