Copper homeostasis (Homo sapiens)

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Cu import, chaperones and exportApical sideCu(I)MTsMetalloreductaseBasolateral sideSTEAPADAM9MAPT (Tau)MT4SP1MT1HMT1AADAM10STEAP1APCSOD3XAF1ATOX1PTENATP7BMTF2PRNPCOMMD1BACE1AKTMT1GGSK3BMDM2COX17SCO1MTF1SCO2SLC31A1 (CTR1)CCND1TP53MT1BCPHL1PMT2AJUNCASP3MT1XXIAPSLC11A2 (DMT1)APPFOXO1MT1JPMT1FMT3ATP7AMT1LCCSADAM17STEAP4SLC31A2 (CTR2)COX11FOXO3PIK3CAMT1ESOD1STEAP2STEAP3APPCu(I)COX17ATP7BATP7ACu(I)/Cu(II)STEAP3STEAP4SLC31A1 (CTR1)Cu(I)Cu(I)


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Mufti AR, Burstein E, Duckett CS; ''XIAP: cell death regulation meets copper homeostasis.''; Arch Biochem Biophys, 2007 PubMed Europe PMC Scholia
  2. Song IS, Chen HH, Aiba I, Hossain A, Liang ZD, Klomp LW, Kuo MT; ''Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells.''; Mol Pharmacol, 2008 PubMed Europe PMC Scholia
  3. Kim BE, Nevitt T, Thiele DJ; ''Mechanisms for copper acquisition, distribution and regulation.''; Nat Chem Biol, 2008 PubMed Europe PMC Scholia
  4. Lutsenko S; ''Human copper homeostasis: a network of interconnected pathways.''; Curr Opin Chem Biol, 2010 PubMed Europe PMC Scholia
  5. Ba LA, Doering M, Burkholz T, Jacob C; ''Metal trafficking: from maintaining the metal homeostasis to future drug design.''; Metallomics, 2009 PubMed Europe PMC Scholia
  6. Nevitt T, Ohrvik H, Thiele DJ; ''Charting the travels of copper in eukaryotes from yeast to mammals.''; Biochim Biophys Acta, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140415view08:59, 19 August 2025EgonwTranslocations
140414view08:58, 19 August 2025EgonwMore unicode
137968view21:03, 10 March 2025KhanspersModified description
136504view12:48, 5 February 2025EweitzMove legend to better preserve left-to-right flow
136503view12:43, 5 February 2025EweitzAdjust per discrepancy
136502view12:42, 5 February 2025EweitzAdjust per Kaavio / PathVisio discrepancy
136501view12:37, 5 February 2025EweitzAlign nodes
136500view12:36, 5 February 2025EweitzUpgrade to metabolite node, refine connection
136499view12:30, 5 February 2025EweitzRefine legend
136498view12:29, 5 February 2025EweitzRefine node alignment
136497view12:25, 5 February 2025EweitzEconomize layout
136496view12:23, 5 February 2025EweitzMove MAPT and APC to ER, like original
136495view12:20, 5 February 2025EweitzIncrease font size
128182view22:38, 28 January 2024EweitzUse standard font weight
128181view22:37, 28 January 2024EweitzStandardize metabolite nodes
128180view22:28, 28 January 2024EweitzRefine color, economize layout
128179view20:23, 28 January 2024EweitzRefine layout of elements in nucleus
128178view20:22, 28 January 2024EweitzFurther economize
128177view20:07, 28 January 2024EweitzUpgrade legend
128176view20:02, 28 January 2024EweitzEconomize layout
128175view19:33, 28 January 2024EweitzModified description
106367view23:06, 22 August 2019KhanspersModified description
105561view06:18, 9 August 2019KhanspersModified description
93705view11:20, 11 August 2017Marvin M2Connected unconnected lines, changed lines in graphical lines in legend
89205view04:04, 23 August 2016AriuttaOntology Term : 'copper homeostasis pathway' added !
87382view11:05, 22 July 2016MaintBotadded missing graphids
84312view00:15, 5 February 2016KhanspersMoved pathway to the left and up
84311view00:03, 5 February 2016Khanspersupdated legend and grouped nodes
84179view21:12, 25 January 2016Khanspersconnected one interaction, added anchors and connectors to transporters, grouped some nodes
84178view20:29, 25 January 2016GdannagText label corrected
84177view20:28, 25 January 2016GdannagConnections and Bibliography
82352view15:52, 26 September 2015EgonwConverted the copper nodes to metabolites with ChEBI identifiers.
82270view15:56, 21 September 2015GiorgiaModified title
82192view16:27, 12 September 2015EgonwAdded GraphIDs to DataNodes that had none.
81938view00:20, 6 September 2015MaintBotManually added missing graphIDs
81937view00:18, 6 September 2015MaintBotAttempting to generate missing graphIDs
80955view23:20, 1 July 2015GdannagModified description
80954view22:54, 1 July 2015GdannagModified description
80953view21:28, 1 July 2015GdannagNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
ADAM9GeneProductENSG00000168615 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
APPGeneProductENSG00000142192 (Ensembl)
ATOX1GeneProductENSG00000177556 (Ensembl)
ATP7AGeneProductENSG00000165240 (Ensembl)
ATP7BGeneProductENSG00000123191 (Ensembl)
BACE1GeneProductENSG00000186318 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCSGeneProductENSG00000173992 (Ensembl)
COMMD1GeneProductENSG00000173163 (Ensembl)
COX11GeneProductENSG00000166260 (Ensembl)
COX17GeneProductENSG00000138495 (Ensembl)
CPHL1PGeneProductENSG00000240216 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MAPT (Tau)GeneProductENSG00000186868 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MT1AGeneProductENSG00000205362 (Ensembl)
MT1BGeneProductENSG00000169688 (Ensembl)
MT1EGeneProductENSG00000169715 (Ensembl)
MT1FGeneProductENSG00000198417 (Ensembl)
MT1GGeneProductENSG00000125144 (Ensembl)
MT1HGeneProductENSG00000205358 (Ensembl)
MT1JPGeneProductENSG00000255986 (Ensembl)
MT1LGeneProductENSG00000260549 (Ensembl)
MT1XGeneProductENSG00000187193 (Ensembl)
MT2AGeneProductENSG00000125148 (Ensembl)
MT3GeneProductENSG00000087250 (Ensembl)
MT4GeneProductENSG00000102891 (Ensembl)
MTF1GeneProductENSG00000188786 (Ensembl)
MTF2GeneProductENSG00000143033 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PRNPGeneProductENSG00000171867 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
SCO1GeneProductENSG00000133028 (Ensembl)
SCO2GeneProductENSG00000130489 (Ensembl)
SLC11A2 (DMT1)GeneProductENSG00000110911 (Ensembl)
SLC31A1 (CTR1)GeneProductENSG00000136868 (Ensembl)
SLC31A2 (CTR2)GeneProductENSG00000136867 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SOD3GeneProductENSG00000109610 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
STEAP1GeneProductENSG00000164647 (Ensembl)
STEAP2GeneProductENSG00000157214 (Ensembl)
STEAP3GeneProductENSG00000115107 (Ensembl)
STEAP4GeneProductENSG00000127954 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
XAF1GeneProductENSG00000132530 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)

Annotated Interactions

No annotated interactions

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