Extracellular vesicle-mediated signaling in recipient cells (Homo sapiens)

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Host cellRecipient cellRTK ligandExosomeRTKEGFRvIIIMultivesicular bodiesPackaging of proteinsWNT3ATGFB1SMAD4TGFB3DKK4WNT5ATGFBR1SMAD2HRASAKT1CTNNB1TGFAAXIN1SMAD3ERBB2KRASTGFB2TGFB1EGFRNRASMAPKAPCTGFBR2RAF1TSPAN8PI3KHGFRWNTTGFBR3HGFMTORMFGE8FrizzledCD133PMutant KRASPExosome mediatedsignal transductionAKT1


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S; ''Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?''; Proteomics, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141647view03:55, 21 November 2025EweitzClear cached dimension
141646view03:54, 21 November 2025EweitzEconomize layout
137159view00:45, 28 February 2025KhanspersModified description
129825view22:57, 22 May 2024EweitzRefine node types for RTK, PI3K
129824view22:53, 22 May 2024EweitzPoint PI3K to gene family
129820view22:29, 22 May 2024EweitzPoint RTK to gene family
106411view21:57, 28 August 2019KhanspersModified description
105591view04:46, 10 August 2019KhanspersModified description
88052view13:46, 25 July 2016SusanOntology Term : 'signaling pathway' added !
79555view12:46, 25 March 2015ZariAdded ID for NRAS and TGFBR2 genes
78078view23:48, 30 November 2014Khanspersconnected interaction
78004view19:34, 5 November 2014AlexanderPicoclarified exsome zoom
77982view18:01, 4 November 2014KhanspersOntology Term : 'nervous system disease' added !
77981view18:00, 4 November 2014KhanspersModified description
77980view17:55, 4 November 2014KhanspersAdded lit ref
77953view19:31, 30 October 2014KhanspersOntology Term : 'cancer' added !
77952view19:30, 30 October 2014Khanspersminor edit
77951view19:28, 30 October 2014KhanspersModified description
77950view19:27, 30 October 2014KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CD133GeneProduct8842 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
DKK4GeneProduct27121 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
FrizzledGeneProduct
HGFGeneProduct3082 (Entrez Gene)
HGFRGeneProduct4233 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MAPKGeneProduct
MFGE8GeneProduct4240 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
NRASProteinNRAS (Uniprot-TrEMBL)
PI3K GeneProduct23533 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
TGFAGeneProduct7039 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2ProteinTGFBR2 (Uniprot-TrEMBL)
TGFBR3GeneProduct7049 (Entrez Gene)
TSPAN8GeneProduct7103 (Entrez Gene)
WNTGeneProduct
WNT3AGeneProduct89780 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)

Annotated Interactions

No annotated interactions

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