Bladder cancer (Homo sapiens)

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33333313333333333DNAMEK1PI3KVEGFMP1ERKMAPK Signaling PathwayEGFRIL-8ErbB Signaling PathwayH-RasRasEGFc-MycERBB2CyclinD1BRAFFGFR3Cell CycleMSK1p85Rb1MMPs24MEK2DNACDK4DNA


Description

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Bibliography

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  1. Calderaro J, Rebouissou S, de Koning L, Masmoudi A, Hأ©rault A, Dubois T, Maille P, Soyeux P, Sibony M, de la Taille A, Vordos D, Lebret T, Radvanyi F, Allory Y; ''PI3K/AKT pathway activation in bladder carcinogenesis.''; Int J Cancer, 2014 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  3. Williams SV, Hurst CD, Knowles MA; ''Oncogenic FGFR3 gene fusions in bladder cancer.''; Hum Mol Genet, 2013 PubMed Europe PMC Scholia
  4. Wolf EM, Liang G, Jones PA; ''Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.''; http://www.ncbi.nlm.nih.gov/pubmed/16474624, 2005 PubMed Europe PMC Scholia
  5. di Martino E, Tomlinson DC, Knowles MA; ''A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.''; Adv Urol, 2012 PubMed Europe PMC Scholia
  6. Juanpere N, Agell L, Lorenzo M, de Muga S, Lأ³pez-Vilarأ³ L, Murillo R, Mojal S, Serrano S, Lorente JA, Lloreta J, Hernأ،ndez S; ''Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer.''; Hum Pathol, 2012 PubMed Europe PMC Scholia
  7. ''Bladder Cancer Pathway''; http://www.genome.jp/dbget-bin/www_bget?pathway:map05219,

History

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CompareRevisionActionTimeUserComment
140995view14:44, 31 October 2025EweitzClear deprecated metadata rendering
137131view23:11, 27 February 2025KhanspersModified description
136669view02:16, 19 February 2025EweitzRefine node position
136668view02:14, 19 February 2025EweitzRefine node position
136667view02:13, 19 February 2025EweitzRefine node position
136666view02:12, 19 February 2025EweitzRefine node position
136665view02:10, 19 February 2025EweitzEconomize layout
136664view01:49, 19 February 2025EweitzAdjust per PathVisio / Kaavio graphical discrepancy
136663view01:48, 19 February 2025EweitzAdjust per PathVisio / Kaavio graphical discrepancy
136662view01:47, 19 February 2025EweitzRefine node alignment
136661view01:46, 19 February 2025EweitzRefine legend
136660view01:43, 19 February 2025EweitzTailor node dimensions, label placement
136659view01:40, 19 February 2025EweitzUse standard gene symbol
136658view01:39, 19 February 2025EweitzEconomize layout
136657view01:34, 19 February 2025EweitzEconomize layout
136656view01:25, 19 February 2025EweitzRefine organelle label graphics, align interactions
136655view01:22, 19 February 2025EweitzIncrease font size
136654view01:16, 19 February 2025EweitzMake nodes shorter, slightly wider
136653view00:57, 19 February 2025EweitzImprove readability of cell type label
128550view23:01, 11 February 2024EweitzEconomize layout, refine legend, standardize case
128549view22:47, 11 February 2024EweitzModified description
128138view19:21, 27 January 2024EweitzStandardize case
127276view15:45, 1 September 2023Khanspersfixed phosphosite
127233view20:13, 25 August 2023Khanspersadded lit ref and updated description
119245view19:24, 22 June 2021FinterlyAdded KEGG pathway info to publicationXref, removed link to youtube song
119084view00:31, 17 June 2021Khanspersupdated ptms
116544view12:13, 7 May 2021EweitzModified title
115349view11:27, 15 February 2021EgonwMade six more pathways clickable
108113view10:20, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106313view17:48, 20 August 2019KhanspersModified description
105669view18:13, 12 August 2019EgonwFixed a WikiPathways identifier.
105442view04:54, 8 August 2019KhanspersModified description
105002view04:53, 28 June 2019KhanspersModified description
104855view14:56, 20 June 2019FehrhartRB1 binds E2F1
104854view14:54, 20 June 2019Fehrhart
103783view20:30, 5 April 2019Khanspersmoved lit refs from state to parent node
103770view00:54, 5 April 2019Khanspersaded literature references
98708view10:46, 30 September 2018EgonwRegular arrow type.
98683view00:31, 28 September 2018KhanspersOntology Term : 'bladder urothelial cell' added !
98682view00:30, 28 September 2018KhanspersOntology Term : 'urinary bladder cancer' added !
98681view00:29, 28 September 2018Khanspersadded phosphosite info
98680view00:13, 28 September 2018Khanspersupdates
97129view18:34, 30 April 2018KhanspersOntology Term : 'papillary renal cell carcinoma' added !
89143view21:56, 22 August 2016AriuttaOntology Term : 'disease pathway' added !
87377view11:05, 22 July 2016MaintBotadded missing graphids
79529view11:42, 24 March 2015Zariadd ID for p85 gene
78868view23:01, 9 February 2015MaintBotadded xrefs
78553view10:31, 7 January 2015MaintBotadded missing graphIds
78174view18:46, 8 December 2014Khanspersupdate
78133view20:18, 4 December 2014KhanspersAdded content

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BRAFProtein
CDK4Protein
Cell Cycle Pathway
CyclinD1Protein
EGFProtein
EGFRProtein
ERBB2Protein
ERKProtein
ErbB Signaling PathwayPathway
FGFR3GeneProductENSG00000068078 (Ensembl)
H-RasProtein
IL-8 Protein
MAPK Signaling PathwayPathway
MEK1Protein
MEK2 Protein
MMPsProtein
MP1 Protein
MSK1Protein
PI3KProtein
RasProtein
Rb1 Protein
VEGF Protein
c-MycProtein
p85Protein

Annotated Interactions

No annotated interactions

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