Interleukin-1 (IL-1) structural pathway (Homo sapiens)

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12JNK1I��B��MKK3 TAK1MAPKp38��IKK��TPL2IRAK4IRAK2TRAF6MYD88TOLLIPIL1AIRAK1TAB1MEKK3MEKK1IFN��/��IRF7NF-��B p105ERK1IL1R1NIKIL1BIL1RAPTAB2TAB3MKK6MKK4MKK7MKK1MKK2IKK��IKK��MAPKp38��JNK2JNK3ERK2I��B��


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR; ''A new nomenclature for IL-1-family genes.''; Trends Immunol, 2001 PubMed Europe PMC Scholia
  2. Dunn E, Sims JE, Nicklin MJ, O'Neill LA; ''Annotating genes with potential roles in the immune system: six new members of the IL-1 family.''; Trends Immunol, 2001 PubMed Europe PMC Scholia
  3. Lawson C, Al-Akoum M, Maheux R, Akoum A; ''Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions.''; Reproduction, 2007 PubMed Europe PMC Scholia
  4. Chang L, Karin M; ''Mammalian MAP kinase signalling cascades.''; Nature, 2001 PubMed Europe PMC Scholia
  5. Martinon F, Mayor A, Tschopp J; ''The inflammasomes: guardians of the body.''; Annu Rev Immunol, 2009 PubMed Europe PMC Scholia
  6. Pizarro TT, Cominelli F; ''Cloning IL-1 and the birth of a new era in cytokine biology.''; J Immunol, 2007 PubMed Europe PMC Scholia
  7. Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O; ''The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer.''; PLoS Comput Biol, 2014 PubMed Europe PMC Scholia
  8. Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM; ''O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.''; EMBO J, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137817view06:42, 8 March 2025EgonwModified description
127757view08:14, 3 December 2023EgonwRemoved a weird char from an Ensembl identifier
117962view10:54, 23 May 2021EweitzModified title
117961view10:53, 23 May 2021EweitzModified title
107551view23:33, 19 October 2019AlexanderPicoModified description
107550view23:33, 19 October 2019AlexanderPicoModified description
105827view23:04, 15 August 2019KhanspersModified description
87707view09:09, 25 July 2016MkutmonOntology Term : 'interleukin-1 signaling pathway' added !
87592view08:01, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
80029view12:23, 1 May 2015EgonwAdded the Ensembl ID for MKK3.
80007view12:30, 30 April 2015Zariannotated TPL2 ,kappaB p65 gene
79580view21:44, 25 March 2015Zari
76330view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
76319view06:59, 2 July 2014Mkutmonfixed datasource for IkappaBbeta datanode
73794view17:04, 24 February 2014AndraAdded the main reference
73793view17:02, 24 February 2014Andracorrected encoding errors of greek alphabet letters
73790view16:55, 24 February 2014Andra
73725view15:49, 19 February 2014AndraAdded references
73724view15:45, 19 February 2014AndraAdded identifiers
73723view15:11, 19 February 2014AndraModified description
73722view15:11, 19 February 2014AndraModified description
73721view14:49, 19 February 2014AndraNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
TAK1GeneProductENSG00000135341 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
IFN��/��Pathway
IKK��GeneProductENSG00000104365 (Ensembl)
IKK��GeneProductENSG00000136560 (Ensembl)
IKK��GeneProductENSG00000213341 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl Human)
IL1BGeneProductENSG00000115008 (Ensembl Human)
IL1R1GeneProductENSG00000115594 (Ensembl Human)
IL1RAPGeneProductENSG00000196083 (Ensembl Human)
IRAK1GeneProductENSG00000184216 (Ensembl Human)
IRAK2GeneProductENSG00000134070 (Ensembl Human)
IRAK4GeneProductENSG00000198001 (Ensembl Human)
IRF7GeneProductENSG00000185507 (Ensembl Human)
I��B��GeneProductP25963 (Uniprot-TrEMBL)
I��B��GeneProductQ15653 (Uniprot-SwissProt)
JNK1GeneProductP45983 (Uniprot-TrEMBL)
JNK2GeneProductP45984 (Uniprot-TrEMBL)
JNK3GeneProductP53779 (Uniprot-TrEMBL)
MAPKp38��GeneProductENSG00000112062 (Ensembl)
MAPKp38��GeneProductENSG00000185386 (Ensembl)
MEKK1GeneProductENSG00000095015 (Ensembl)
MEKK3GeneProductENSG00000198909 (Ensembl)
MKK1 GeneProductENSG00000169032 (Ensembl)
MKK2 GeneProductENSG00000126934 (Ensembl)
MKK3 GeneProductMKK3 (Ensembl)
MKK4 GeneProductENSG00000065559 (Ensembl)
MKK6GeneProductENSG00000108984 (Ensembl)
MKK7 GeneProductENSG00000076984 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl Human)
NF-��B p105GeneProductP19838 (Uniprot-TrEMBL)
NIKGeneProductENSG00000006062 (Ensembl)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TAB3GeneProductENSG00000157625 (Ensembl)
TOLLIPGeneProductENSG00000078902 (Ensembl Human)
TPL2GeneProduct
TRAF6GeneProductENSG00000175104 (Ensembl Human)

Annotated Interactions

No annotated interactions

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