T cell receptor and co-stimulatory signaling (Homo sapiens)
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Description
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Ontology Terms
Saving...Bibliography
- Takahashi K, Yan I, Haga H, Patel T; ''Long non-coding RNA in liver diseases.''; Hepatology, 2014 PubMed Europe PMC Scholia
- Srikanth S, Gwack Y; ''Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.''; Mol Cells, 2013 PubMed Europe PMC Scholia
History
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External references
DataNodes
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Protein | |||
| CD28 | Protein | co-stimulatory molecule | CD28 is a co-stimulatory surface receptor. It bind B7-1 and B7-2. After CD28 binds its ligand, it is phosphorylated by Lck. The effect of this phosphorylation activates P13K to generate PIP3 which recruits Itk to the cell membrane where Lck can phosphorylate it. Then Itk-P can recruit PLC-g |
| CTLA-4 | Protein | inhibitory checkpoint molecule | Expression is enhanced by IL-2.
Function is controlled largely by regulation of its surface expression. Initially CTLA-4 is in the intracellular membrane but moves to the cell surface after T-cell receptor signaling. When CTLA-4 cytoplasmic tail is NOT phosphorylated it binds to AP-2 (clathrin adapter molecule) and is removed from the surface. When the tail is phosphorylated AP-2 cannot bind and CTLA-4 is expressed on the surface. CTLA-4 competes with CD28 for B7 ligand, and it has a higher affinity of B7 in part because CTLA-4 binds B7 in a dimer. CTLA-4 interfers with the formation of lipid rafts, TCR:ZAP70 microclusters, and central supramolecular activation complex. |
| PD-1 | Protein | Programmed Cell Death 1 | PD-1 is repressed by pro-inflammatp |
| TCR | Complex | T cell receptor complex |
Annotated Interactions
No annotated interactions
