S1P pathways and spinal cord injury (Mus musculus)

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15123151Neural Stem CellVASCULARPERMEABILITYNucleusMIGRATIONCatalystSPLABC-TFTY720-PSphK2BCL-2SphFTY720-PSphK1CERFTY720S1PR1DH-CERApoptosisFTY720CaspasesSMS1PFTY720DH-SphABC-TFTY720S1PDe novo synthesisLymphocytesLYMPHOPENIAREACTIVITYGLIAL SCARAstrocytesSPNS24ABC-TBCL-XL5S1PR15?OlidodendrocytesREMYELINATIONS1PR3S1PR555


Description

No description

Comments

 
Preliminary pathway, we are working on it (31 03 2012)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kimura A, Ohmori T, Ohkawa R, Madoiwa S, Mimuro J, Murakami T, Kobayashi E, Hoshino Y, Yatomi Y, Sakata Y; ''Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.''; Stem Cells, 2007 PubMed Europe PMC Scholia
  2. Norimatsu Y, Ohmori T, Kimura A, Madoiwa S, Mimuro J, Seichi A, Yatomi Y, Hoshino Y, Sakata Y; ''FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.''; Am J Pathol, 2012 PubMed Europe PMC Scholia
  3. Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T; ''The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  4. Bandhuvula P, Tam YY, Oskouian B, Saba JD; ''The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  5. Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N; ''Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.''; Cancer Res, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106869view13:34, 17 September 2019MaintBotHMDB identifier normalization
87646view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
87644view08:54, 25 July 2016LindarieswijkOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
78423view10:26, 7 January 2015MaintBotadded missing graphIds
72023view12:45, 24 October 2013Mkutmonfixed unconnected lines
71760view20:25, 17 October 2013MaintBot
71738view20:18, 17 October 2013MaintBotUpdated data sources
59059view20:58, 21 February 2013MaintBotUpdated Ensembl data source
58145view21:53, 8 February 2013MaintBotModified categories
48030view09:25, 27 April 2012MNietoDiazPeriodical save, work in progress
48029view07:21, 27 April 2012MNietoDiazPeriodical save, work in progress
48017view12:22, 26 April 2012MNietoDiazPeriodical save, work in progress
48016view11:56, 26 April 2012MNietoDiazPeriodical save, work in progress
48015view10:22, 26 April 2012MNietoDiazPeriodical save, work in progress
48014view10:11, 26 April 2012MNietoDiazPeriodical save, work in progress
48011view09:40, 26 April 2012MNietoDiazPeriodical save, work in progress
48010view08:28, 26 April 2012MNietoDiazPeriodical save, work in progress
48009view08:17, 26 April 2012MNietoDiazPeriodical save, work in progress
48008view08:07, 26 April 2012MNietoDiazPeriodical save, work in progress
48007view07:37, 26 April 2012MNietoDiazPeriodical save, work in progress
47637view20:33, 31 March 2012MNietoDiazNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?
ABC-TProteinABC transporters
ApoptosisPathway
BCL-2Protein
BCL-XLProtein
CERMetabolite
CaspasesProtein
CatalystGeneProduct
DH-CERMetabolite
DH-SphMetabolite
FTY720-PMetabolite
FTY720MetaboliteCHEMBL314854 (ChEMBL compound)
S1PMetaboliteCHEMBL225155 (ChEMBL compound)
S1PR1ProteinO08530 (Uniprot-TrEMBL)
S1PR3ProteinQ9Z0U9 (Uniprot-TrEMBL)
S1PR5ProteinQ91X56 (Uniprot-TrEMBL)
SMMetaboliteHMDB01348 (HMDB) Sphingomyelin
SPLProteinENSMUSG00000020097 (Ensembl)
SPNS2 Protein
SphMetaboliteCHEMBL67166 (ChEMBL compound)
SphK1ProteinENSMUSG00000061878 (Ensembl)
SphK2ProteinENSMUSG00000057342 (Ensembl)

Annotated Interactions

No annotated interactions
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