Nanoparticle triggered regulated necrosis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
2. Ma YH, Huang CP, Tsai JS, Shen MY, Li YK, Lin LY; ''Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.''; Toxicol Lett, 2011 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	137430	view	09:27, 2 March 2025	Egonw	Modified description
	119820	view	10:33, 28 August 2021	Egonw	Made a few pathways clickable
	110691	view	13:47, 28 May 2020	Laurent	Added missing DataNode types - added ID to Ge NP
	106661	view	21:20, 12 September 2019	Khanspers	Modified description
	106207	view	12:10, 16 August 2019	MaintBot	HMDB identifier normalization
	105662	view	05:17, 10 August 2019	Khanspers	Modified description
	102135	view	09:25, 2 December 2018	Egonw	Fixed the Uniprot ID of TNF.
	102134	view	09:24, 2 December 2018	Egonw	Replaced Wikipedia with Wikidata identifiers.
	97539	view	14:33, 24 May 2018	Egonw	Fixed a character encoding issue.
	97519	view	13:52, 24 May 2018	Timverbruggen	increase mappings
	97510	view	13:39, 24 May 2018	Timverbruggen	increased mapping
	92316	view	08:50, 20 May 2017	Egonw	Ontology Term : 'nanomaterial response pathway' added !
	86006	view	00:51, 24 June 2016	Khanspers	changed look of pathway nodes
	86000	view	00:30, 24 June 2016	Khanspers	Connected interactions, updated xrefs, assigned node types
	85999	view	00:22, 24 June 2016	Khanspers	connected lines, changed gene nodes to pathway nodes where appropriate
	85026	view	14:21, 6 April 2016	Mkutmon	remove special characters and add graphical annotations instead
	81068	view	18:23, 19 July 2015	Egonw	Typed ceramide as metabolite.
	81067	view	18:22, 19 July 2015	Egonw	Use a ChEBI identifier instead of a Wikipedia one.
	77901	view	14:47, 28 October 2014	Bart Smeets	Modified description
	77900	view	14:47, 28 October 2014	Bart Smeets	Modified description
	77667	view	12:01, 5 October 2014	Egonw	Replaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
	74182	view	09:32, 3 April 2014	Bart Smeets	Added wiki entries
	74143	view	10:31, 1 April 2014	Bart Smeets	Expanded description of nanoparticles in pathway, added corresponding literature references.
	73826	view	15:05, 25 February 2014	Bart Smeets	Fixed some wikipedia entries
	73825	view	15:01, 25 February 2014	Bart Smeets	Added a few GeneIDs
	71447	view	19:13, 17 October 2013	MaintBot	Updated data sources
	70991	view	20:50, 21 September 2013	Egonw	Added a few identifiers.
	68057	view	13:10, 29 June 2013	Egonw	Completed the pathway as given in the figure.
	68054	view	13:04, 29 June 2013	Egonw	Periodical save, work in progress
	66148	view	08:19, 15 June 2013	Egonw	Added the literature ref again.
	65706	view	12:26, 11 June 2013	Egonw	Added the caspase 8 identifier, and widened the Necroptosis box.
	65603	view	16:18, 10 June 2013	Egonw	More content of the pathway.
	65457	view	10:27, 8 June 2013	Egonw	Ontology Term : 'necrosis pathway' added !
	65447	view	08:02, 8 June 2013	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ATP	Metabolite
Arachidonic acid	Metabolite	HMDB01043 (HMDB)
CASP8	GeneProduct	ENSG00000064012 (Ensembl)
Calcium	Metabolite	HMDB00464 (HMDB)
Calpains
Ceramide
FADD	GeneProduct	ENSG00000168040 (Ensembl)
Ferritin
Glutaminolysis
Glycogenolysis
Glycolysis
Iron	Metabolite	HMDB00692 (HMDB)
JNK
Labile iron pool
Nanoparticle
Nec-1	Metabolite	2828334 (PubChem-compound)
Necroptosis	Pathway
PAMPs
PARP1	GeneProduct	ENSG00000143799 (Ensembl)
RIPK1	GeneProduct	ENSG00000137275 (Ensembl)
RIPK3	GeneProduct	ENSG00000129465 (Ensembl)
ROS	Metabolite	CHEBI:26523 (ChEBI)
SMases	Protein
TNFR1	GeneProduct
TNF	Protein	TNF (Uniprot/TrEMBL)
TRADD	GeneProduct	ENSG00000102871 (Ensembl)
TRIF	GeneProduct
cPLA₂
lipoxygenase
pH ↓

Annotated Interactions

No annotated interactions