AGE/RAGE pathway (Homo sapiens)

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MAPK9PSMAD3PMAPK3PSMAD3PSTAT5BPIKBKBPAGERPAGE/RAGE Signaling PathwayCalcification of smooth muscle cellsNeuriteAGERPCDC42GTPRAC1GgGTPRHOAGTPCASP3IRS1PRKCAPMYD88IRAK4MSNPTIRAPROCK1PHRASSRCGTPPMAPK1PFOXO1dePSP1NFKB1PRELAPAKT1MAPK14dePPMAPK8PPFOXO4JAK2PSTAT1STAT3PCHUKPCASP8PNFKBIAUbPNFKB1RELAPPSMAD2PSMAD2PTubular epithelium myofibroblast transitionDIAPH1PLCPLA2G4ANa+ K+ ATPasePNeutrophilRearrangement of the actin cytoskeletonAutophagy in vascular smooth muscle cellsDissolution of gap junctions in human hepatoma cellsCell proliferationATF2JUNPPFibroblastsCASP9Retinal pericytesOsteoblastsINS-1 cellsNONeuroblastoma cellsIncrease in monolayer permeabilityRenal cellular hypertrophyMitogeneis in NRK-49F cellsMAP2K1PRAF1PALPLMonocyte adhesion to retinal endothelial cellsNCF1PSTAT5APSP1NOXApoptosis inFOXO1FOXO4Osteogenicdifferentiationof VSMCsRenal proximal tubular cellsNOS2NOS3Endothelial cellDegradationDissociationH2O2MitochondrialPRKCBPRKCZProteinDissociation of PPIReceptorProteinTransportLeads toInduced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUEnzymeEnzyme complex or specific component unknownCYNUCYNUCYNUCYNUCYNUCYNUCMLCELAGE-modified albuminPentosidineLigandSmall moleculesEnzymeProteins activated (identified by assays)MTMitochondriaCYMTApoptosis inPodocytesFibroblastsCYCSCYCSSOD1burstTGF-betaindependentDephosphorylationInhibition of proliferation and migration ofbone marrow mesenchymal stem cellsT-cellsEndothelial cell permeabilityPIP2DAGCa2+Arachidonic acidROSoutgrowthpermeabilitytransitiondysfunctionsGlyc-FBSPhosphorylated stateUbUbiquitinated stateGgGeranylgeranylated statedePDephosphrylated stateRegulation ofcytoskeletonCML-CollagenFormation of F-actin stress fibersSHC1PEGFRPDDOSTInternalizationAGE removalandAGEsMSR1AGEsINSINSRHIF1AHIF1ACYNUInhibition oftubulogenesis ofproximal tubule cellsEZRdePPPlacenta andgestational membranesProstaglandin F2alphaProstaglandin E2Released fromChondrocytesLGALS3AGEsincreasedPRKCDInhibition ofPMicroglial cellsMMP2MMP14MMP13MMP9MMP7


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History

CompareRevisionActionTimeUserComment
52520view10:20, 15 October 2012NetPathDeleted pathway: file not correct
52517view10:17, 15 October 2012NetPathNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGE-modified albuminProtein
AGERProtein177 (Entrez Gene)
AGEsProtein
AKT1Protein207 (Entrez Gene)
ALPLProtein249 (Entrez Gene)
ATF2Protein1386 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP8Protein841 (Entrez Gene)
CASP9Protein842 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CELProtein
CHUKProtein1147 (Entrez Gene)
CML-CollagenProtein
CMLProtein
CYCSProtein54205 (Entrez Gene)
DDOSTProtein1650 (Entrez Gene)
DIAPH1Protein1729 (Entrez Gene)
EGFRProtein1956 (Entrez Gene)
EZRProtein7430 (Entrez Gene)
FOXO1Protein2308 (Entrez Gene)
FOXO4Protein4303 (Entrez Gene)
Glyc-FBSProtein
H2O2Protein
HIF1AProtein3091 (Entrez Gene)
HRASProtein3625 (Entrez Gene)
IKBKBProtein3551 (Entrez Gene)
INSProtein3630 (Entrez Gene)
INSRProtein3643 (Entrez Gene)
IRAK4Protein51135 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LGALS3Protein3958 (Entrez Gene)
LigandProtein
MAP2K1Protein5604 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP13Protein4322 (Entrez Gene)
MMP14Protein4323 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMP7Protein4316 (Entrez Gene)
MMP9Protein4318 (Entrez Gene)
MSNProtein4478 (Entrez Gene)
MSR1Protein4481 (Entrez Gene)
MYD88Protein4615 (Entrez Gene)
NCF1Protein653361 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NOProtein
NOS2Protein4843 (Entrez Gene)
NOS3Protein4846 (Entrez Gene)
NOXProtein
Na+ K+ ATPaseProtein
PLA2G4AProtein5321 (Entrez Gene)
PLCProtein
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCZProtein5590 (Entrez Gene)
PentosidineProtein
ProteinGeneProduct
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOAProtein387 (Entrez Gene)
ROCK1Protein6093 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SMAD2Protein4087 (Entrez Gene)
SMAD3Protein4088 (Entrez Gene)
SOD1Protein6647 (Entrez Gene)
SP1Protein6667 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TIRAPProtein114609 (Entrez Gene)

Annotated Interactions

No annotated interactions

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