Opioid Signalling (Homo sapiens)

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1-31515314738-4051379-1215, 1650176, 741, 42815514431552, 53848, 494635, 3633, 3422, 231327, 2844, 452925471819-21301524-2632nucleoplasmendoplasmic reticulum lumencytosolADPPKA catalytic subunitAdenylate cyclase (Mg2+ cofactor)G-protein alpha (i/o/z/t) subunitG-protein alpha:GDPPDE 4ATPG alpha-olf:GDP:Adenylate cyclase (active) complexPP2B catalytic (Fe3+, Zn2+):Active CalmodulindiacylglycerolsCalmodulinactive PKC (alpha, gamma, delta)Opioid peptidephospho-GRK2OrthophosphateGRK2:calmodulinActive PLA2:phosphatidylcholineATP3',5'-Cyclic AMPCalmodulin:CaMK IVOrthophosphatePhosphatidylcholineG alpha-olf:GTPactive CalmodulinGRK2active Cam-PDE 1G-protein alpha (i): GTPcAMP-specific 3',5'-cyclic phosphodiesterase 4BH2OCREBMu-type opioid receptor(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)Cam-PDE 1 homodimerCDK5Adenylate cyclase (Mg2+ cofactor)Opioid:MOR:G-protein complex3',5'-Cyclic AMPPKA tetramerPLC-betaOrthophosphateCREB2-LysophosphatidylcholineADPH2OADPOpioid:MOR:G protein-GTP complexDARPP-32 phosphorylated on Thr75Activated PLC beta 1/4phospho-CaMK IV:CalmodulinPP2B catalytic (Fe3+, Zn2+)Serine/threonine protein phosphatase PP1-alpha 1 catalytic subunitGDP1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)ADPADPphospho-CREBAdenylate cyclase (Mg2+ cofactor)Opioid:MOR:G protein-GDP complexG protein alpha:GTP complexDARPP-32 phosporylated on T34CalciumOpioid:MORphospho-CREB dimerG-protein alpha (i):GDPcAMP:PKA regulatory subunitG alpha-olf:GTP:Adenylate cyclase (active) complex3',5'-Cyclic AMPATPOrthophosphatepyrophosphateProtein Kinase A, catalytic subunitsADPG alpha-olf:GDP complexPhosphatidyl cholinePhosphorylated (Thr75) DARPP-32:PKAGTPpyrophosphatecPLA2CalciumIP3 receptor homotetramerGTP(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)GDPphospho-CREBH2OG-protein beta-gamma complexAdenylate cyclase (Mg2+ cofactor)ATPCalmodulin:CaMK IVATPArachidonateActivated ERK2ATPDARPP-32 (and/or phosphorylated)G alpha-olf:GDP complexPhosphorylated cAMP-specific 3',5'-cyclic phosphodiesterase 4BOrthophosphatePhosphorylated (T34) DARPP-32:PP1AADPphospho-cPLA2AMPATPATPATPH2OPKA catalytic subunitActive Calmodulin1D-myo-Inositol 1,4,5-trisphosphatePP2A-ABdeltaC complexH2OAMP3',5'-Cyclic AMPcAMP-dependent protein kinase, alpha-catalytic subunitG protein-GDP complexDARPP-32 (for CDK5 phosphorylation)IP3 receptor:IP3 complexCaMKIVPP2B complexG-protein alpha (i):GTP:Adenylate cyclaseH2O4


Description

Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP).

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History

CompareRevisionActionTimeUserComment
39969view19:01, 21 January 2011MaintBotDeleted pathway: errors in gpml
39902view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Gi alpha1:GDP:

Adenylate cyclase): (G alpha-olf:GDP)

ComplexREACT_15896 (Reactome)
(Gi alpha1:GTP:

Adenylate cyclase): (G alpha-olf:GDP)

ComplexREACT_15853 (Reactome)
(Gi alpha1:GTP:

Adenylate cyclase): (G alpha-olf:GTP)

ComplexREACT_15996 (Reactome)
1-Phosphatidyl-

D-myo-inositol 4,5-bisphosphate

Unknown18348 (ChEBI)
1D-myo-Inositol

1,4,5-trisphosphate

Metabolite16595 (ChEBI)
2-

Lysophosphatidylcholi ne

Unknown17504 (ChEBI)
3',5'-Cyclic AMP Metabolite17489 (ChEBI)
ADP Metabolite16761 (ChEBI)
AMP Metabolite16027 (ChEBI)
ATP Metabolite15422 (ChEBI)
Activated ERK2 ProteinP28482 (UniProt)
Activated PLC beta

1/4

ComplexREACT_15568 (Reactome)
Active

Calmodulin

ComplexREACT_3178 (Reactome)
Active PLA2:

phosphatidylcholine

ComplexREACT_15631 (Reactome)
Adenylate cyclase

(Mg2+ cofactor)

ComplexREACT_17689 (Reactome)
Arachidonate Metabolite15843 (ChEBI)
CDK5 ProteinQ00535 (UniProt)
CREB ProteinP16220 (UniProt)
CaMKIV ProteinQ16566 (UniProt)
Calcium Metabolite29108 (ChEBI)
Calmodulin ProteinP62158 (UniProt)
Calmodulin:CaMK IV ComplexREACT_15739 (Reactome)
Calmodulin:CaMK IV ComplexREACT_15747 (Reactome)
Cam-PDE 1

homodimer

ComplexREACT_5507 (Reactome)
DARPP-32

phosphorylated on Thr75

ProteinREACT_16096 (Reactome)
DARPP-32

phosporylated on T34

ProteinREACT_15578 (Reactome)
DARPP-32 (and/or

phosphorylated)

ProteinREACT_17763 (Reactome)
DARPP-32 (for CDK5

phosphorylation)

ProteinREACT_17935 (Reactome)
G alpha-olf:GDP

complex

ComplexREACT_17352 (Reactome)
G alpha-olf:GDP:

Adenylate cyclase (active) complex

ComplexREACT_15796 (Reactome)
G alpha-olf:GTP ComplexREACT_16015 (Reactome)
G alpha-olf:GTP:

Adenylate cyclase (active) complex

ComplexREACT_17212 (Reactome)
G protein alpha:GTP

complex

ComplexREACT_17389 (Reactome)
G protein-GDP

complex

ComplexREACT_15793 (Reactome)
G-protein alpha

(i):GDP

ComplexREACT_19806 (Reactome)
G-protein alpha

(i):GTP:Adenylate cyclase

ComplexREACT_19914 (Reactome)
G-protein alpha

(i/o/z/t) subunit

ProteinREACT_16054 (Reactome)
G-protein alpha (i):

GTP

ComplexREACT_19580 (Reactome)
G-protein alpha:GDP ComplexREACT_17952 (Reactome)
G-protein beta-

gamma complex

ComplexREACT_15674 (Reactome)
GDP Metabolite17552 (ChEBI)
GRK2 ProteinP25098 (UniProt)
GRK2:

calmodulin

ComplexREACT_17570 (Reactome)
GTP Metabolite15996 (ChEBI)
H2O Metabolite15377 (ChEBI)
IP3 receptor

homotetramer

ComplexREACT_12247 (Reactome)
IP3 receptor:IP3

complex

ComplexREACT_12249 (Reactome)
Mu-type opioid

receptor

ProteinP35372 (UniProt)
Opioid peptide ProteinREACT_15976 (Reactome)
Opioid:MOR ComplexREACT_15680 (Reactome)
Opioid:MOR:G

protein-GDP complex

ComplexREACT_15815 (Reactome)
Opioid:MOR:G

protein-GTP complex

ComplexREACT_15831 (Reactome)
Opioid:MOR:G-protein

complex

ComplexREACT_15585 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PDE 4 UnknownREACT_5541 (Reactome) cAMP selective hydrolase
PKA catalytic subunit ProteinREACT_3031 (Reactome)
PKA tetramer ComplexREACT_5749 (Reactome)
PLC-beta ProteinREACT_15673 (Reactome)
PP2A-ABdeltaC

complex

ComplexREACT_5648 (Reactome)
PP2B catalytic (Fe3+,

Zn2+)

ComplexREACT_18243 (Reactome)
PP2B catalytic (Fe3+,

Zn2+):Active Calmodulin

ComplexREACT_17373 (Reactome)
PP2B complex ComplexREACT_17149 (Reactome)
Phosphatidyl choline Metabolite16110 (ChEBI)
Phosphatidylcholine Unknown16110 (ChEBI)
Phosphorylated

(Thr75) DARPP- 32:PKA

ComplexREACT_17157 (Reactome)
Phosphorylated

cAMP-specific 3',5'- cyclic phosphodiesterase 4B

ProteinQ07343 (UniProt)
Phosphorylated (T34)

DARPP-32:PP1A

ComplexREACT_17348 (Reactome)
Protein Kinase A,

catalytic subunits

ProteinREACT_2480 (Reactome)
Serine/threonine

protein phosphatase PP1-alpha 1 catalytic subunit

ProteinP62136 (UniProt)
active

Calmodulin

ComplexREACT_10340 (Reactome)
active Cam-PDE 1 ComplexREACT_3728 (Reactome)
active PKC

(alpha, gamma, delta)

ComplexREACT_16103 (Reactome)
cAMP-dependent

protein kinase, alpha-catalytic subunit

ProteinP17612 (UniProt)
cAMP-specific 3',5'-

cyclic phosphodiesterase 4B

ProteinQ07343 (UniProt)
cAMP:PKA regulatory

subunit

ComplexREACT_4571 (Reactome)
cPLA2 ProteinP47712 (UniProt)
diacylglycerols Metabolite18035 (ChEBI)
phospho-CREB ProteinP16220 (UniProt)
phospho-CREB dimer ComplexREACT_17630 (Reactome)
phospho-CaMK IV:

Calmodulin

ComplexREACT_15743 (Reactome)
phospho-GRK2 ProteinP25098 (UniProt)
phospho-cPLA2 ProteinP47712 (UniProt)
pyrophosphate Metabolite29888 (ChEBI)

Annotated Interactions

No annotated interactions

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