miRNAs involved in DNA damage response (Homo sapiens)

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7116, 1065, 8, 1222212624, 93gene product used more than once in this pathwaymicroRNA clusterinhibitionactivationmicroRNAgene producthsa-mir-29bhsa-mir-203hsa-mir-34chsa-miR-424/450b clusterhsa-mir-424hsa-mir-145E2F1hsa-mir-374bhsa-mir-195hsa-mir-23b/24-1 clusterhsa-mir-15ahsa-mir-372hsa-miR-29b-1/29a clusterCDC25A2hsa-mir-27bATMTP53CCND3CCND2hsa-mir-15b/16-2 clusterhsa-mir-210hsa-mir-143CCND1CDK6hsa-mir-181a-1hsa-miR-21genehsa-mir-449ahsa-miR-210 geneE2F1hsa-mir-16hsa-mir-29bhsa-mir-23bhsa-mir-19ahsa-miR-29b-2/29c clusterhsa-mir-27ahsa-miR-17/92a-1 clusterH2AFXhsa-mir-24hsa-mir-21CCNE1hsa-miR-106b/25 clusterhsa-mir-29aRAD52CASP9hsa-mir-373hsa-let-7ahsa-mir-23a/24-2 clusterhsa-let-7bhsa-mir-450ahsa-mir-93hsa-miR-223 genehsa-mir-133ahsa-mir-181b-1hsa-mir-106bhsa-mir-374b/421 clusterCDKN1Ahsa-mir-17hsa-mir-34bhsa-mir-34b/34c clusterhsa-let-7fc-MycCDKN1Bhsa-mir-29cABL1has-miR-195/497 clusterhas-let-7a-2/100 clusterhas-mir-181a-2/181b-2 clusterhsa-mir-330hsa-mir-23ahsa-mir-20ahsa-mir-450bhsa-mir-421hsa-let-7a-1/7d clusterhsa-mir-497hsa-mir-542hsa-mir-92ahsa-mir-449chas-mir-181a-1/181b-1 clusterhsa-mir-371/373 clusterhsa-let-7a-3/7b clusterc-Mychsa-mir-222hsa-mir-221hsa-mir-25hsa-mir-503hsa-mir-15a/16-1 clusterhsa-mir-371CREB1hsa-mir-223hsa-miR-330 genehsa-miR-203 genehsa-mir-15bhsa-mir-1-2/133a-1 clusterhsa-mir-18ahsa-mir-100hsa-let-7dhsa-miR-449c/449a clusterAPAF1hsa-mir 133a-2 genehsa-mir-19bhsa-mir-449bhsa-miR-222/221 clusterhsa-mir-3074hsa-mir-1hsa-mir-143/145 clusterCCND1


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Bibliography

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  2. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
  3. Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, Linsley PS, Cleary MA; ''MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  4. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  5. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMed Europe PMC Scholia
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  7. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
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  9. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  10. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT; ''Widespread microRNA repression by Myc contributes to tumorigenesis.''; Nat Genet, 2008 PubMed Europe PMC Scholia
  11. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMed Europe PMC Scholia
  12. Quintavalle M, Elia L, Condorelli G, Courtneidge SA; ''MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.''; J Cell Biol, 2010 PubMed Europe PMC Scholia
  13. Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  14. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMed Europe PMC Scholia
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  17. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY; ''MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  18. Yamakuchi M, Lowenstein CJ; ''MiR-34, SIRT1 and p53: the feedback loop.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
  19. Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M; ''Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.''; Cancer Cell, 2008 PubMed Europe PMC Scholia
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  21. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMed Europe PMC Scholia
  22. Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M; ''Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  23. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  24. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
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  26. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  27. Cuesta R, Martínez-Sánchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
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  29. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z, Zheng X; ''miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.''; Nucleic Acids Res, 2008 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
137606view17:56, 5 March 2025KhanspersModified description
118363view13:43, 27 May 2021Mkutmonremove unused publication ref
105864view23:21, 15 August 2019KhanspersModified description
102985view12:29, 31 January 2019SusanUpdated microRNA annotations
102984view11:59, 31 January 2019SusanAdapted annotation of microRNAs hsa-mir-497 and hsa-mir-20a
98356view05:43, 24 August 2018EgonwFixed weird chars in author names.
98338view13:28, 23 August 2018EgonwUpdated the MIR21 identifier.
94759view15:43, 5 October 2017Mkutmonlines in legend changed to graphical lines
84697view21:15, 15 March 2016KhanspersQuick edit to datanode annotation or property
78559view10:31, 7 January 2015MaintBotadded missing graphIds
70088view17:52, 12 July 2013MaintBotModified title
70087view17:52, 12 July 2013MaintBotupdating to 2013 schema
59082view21:58, 21 February 2013MaintBotUpdated Ensembl data source
53519view12:41, 8 November 2012Andra
53518view12:40, 8 November 2012Andra
45378view21:35, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44909view10:27, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41207view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
37867view17:22, 13 July 2010KhanspersModified categories
37421view14:16, 1 June 2010J.krumeichSpecify description
37420view14:10, 1 June 2010J.krumeichPeriodical save, work in progress
37417view13:42, 1 June 2010J.krumeichModified description
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
APAF1GeneProduct317 (Entrez Gene)
ATMGeneProduct472 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDC25A2GeneProduct993 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
H2AFXGeneProduct3014 (Entrez Gene)
RAD52GeneProduct5893 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)
has-let-7a-2/100 clusterGeneProduct
has-miR-195/497 clusterGeneProduct
has-mir-181a-1/181b-1 clusterGeneProduct
has-mir-181a-2/181b-2 clusterGeneProduct
hsa-let-7a-1/7d clusterGeneProduct
hsa-let-7a-3/7b clusterGeneProduct
hsa-let-7aGeneProductENSG00000199165 (Ensembl Human)
hsa-let-7bGeneProductENSG00000207875 (Ensembl Human)
hsa-let-7dGeneProductENSG00000199133 (Ensembl Human)
hsa-let-7fGeneProductENSG00000199072 (Ensembl Human)
hsa-miR-106b/25 clusterGeneProduct
hsa-miR-17/92a-1 clusterGeneProduct
hsa-miR-203 geneGeneProduct
hsa-miR-210 geneGeneProduct
hsa-miR-21geneGeneProduct
hsa-miR-222/221 clusterGeneProduct
hsa-miR-223 geneGeneProduct
hsa-miR-29b-1/29a clusterGeneProduct
hsa-miR-29b-2/29c clusterGeneProduct
hsa-miR-330 geneGeneProduct
hsa-miR-424/450b clusterGeneProduct
hsa-miR-449c/449a clusterGeneProduct
hsa-mir 133a-2 geneGeneProduct
hsa-mir-1-2/133a-1 clusterGeneProduct
hsa-mir-100GeneProductENSG00000207994 (Ensembl Human)
hsa-mir-106bGeneProductENSG00000208036 (Ensembl Human)
hsa-mir-133aGeneProductENSG00000207786 (Ensembl Human)
hsa-mir-143/145 clusterGeneProduct
hsa-mir-143GeneProductENSG00000208035 (Ensembl Human)
hsa-mir-145GeneProductENSG00000207700 (Ensembl Human)
hsa-mir-15a/16-1 clusterGeneProduct
hsa-mir-15aGeneProductENSG00000207718 (Ensembl Human)
hsa-mir-15b/16-2 clusterGeneProduct
hsa-mir-15bGeneProductENSG00000207779 (Ensembl Human)
hsa-mir-16GeneProductENSG00000208006 (Ensembl Human)
hsa-mir-17GeneProductENSG00000207745 (Ensembl Human)
hsa-mir-181a-1GeneProductENSG00000207759 (Ensembl Human)
hsa-mir-181b-1GeneProductENSG00000207975 (Ensembl Human)
hsa-mir-18aGeneProductENSG00000199180 (Ensembl Human)
hsa-mir-195GeneProductENSG00000207929 (Ensembl Human)
hsa-mir-19aGeneProductENSG00000207610 (Ensembl Human)
hsa-mir-19bGeneProductENSG00000207560 (Ensembl Human)
hsa-mir-1GeneProductENSG00000207694 (Ensembl Human)
hsa-mir-203GeneProductENSG00000207568 (Ensembl Human)
hsa-mir-20aGeneProductENSG00000199149 (Ensembl Human)
hsa-mir-210GeneProductENSG00000199038 (Ensembl Human)
hsa-mir-21GeneProductENSG00000199004 (Ensembl Human)
hsa-mir-221GeneProductENSG00000207870 (Ensembl Human)
hsa-mir-222GeneProductENSG00000207725 (Ensembl Human)
hsa-mir-223GeneProductENSG00000207939 (Ensembl Human)
hsa-mir-23a/24-2 clusterGeneProduct
hsa-mir-23aGeneProductENSG00000207980 (Ensembl Human)
hsa-mir-23b/24-1 clusterGeneProduct
hsa-mir-23bGeneProductENSG00000207563 (Ensembl Human)
hsa-mir-24GeneProductENSG00000207617 (Ensembl Human)
hsa-mir-25GeneProductENSG00000207547 (Ensembl Human)
hsa-mir-27aGeneProductENSG00000207808 (Ensembl Human)
hsa-mir-27bGeneProductENSG00000207864 (Ensembl Human)
hsa-mir-29aGeneProductENSG00000198981 (Ensembl Human)
hsa-mir-29bGeneProductENSG00000207748 (Ensembl Human)
hsa-mir-29bGeneProductENSG00000207790 (Ensembl Human)
hsa-mir-29cGeneProductENSG00000207966 (Ensembl Human)
hsa-mir-3074GeneProductMI0014181 (miRBase)
hsa-mir-330GeneProductENSG00000199066 (Ensembl Human)
hsa-mir-34b/34c clusterGeneProduct
hsa-mir-34bGeneProductENSG00000207811 (Ensembl Human)
hsa-mir-34cGeneProductENSG00000207562 (Ensembl Human)
hsa-mir-371/373 clusterGeneProduct
hsa-mir-371GeneProductENSG00000199031 (Ensembl Human)
hsa-mir-372GeneProductENSG00000199095 (Ensembl Human)
hsa-mir-373GeneProductENSG00000199143 (Ensembl Human)
hsa-mir-374b/421 clusterGeneProduct
hsa-mir-374bGeneProductENSG00000212027 (Ensembl Human)
hsa-mir-421GeneProductENSG00000202566 (Ensembl Human)
hsa-mir-424GeneProductENSG00000199097 (Ensembl Human)
hsa-mir-449aGeneProductENSG00000198983 (Ensembl Human)
hsa-mir-449bGeneProductENSG00000207728 (Ensembl Human)
hsa-mir-449cGeneProductMI0003823 (miRBase)
hsa-mir-450aGeneProductENSG00000207755 (Ensembl Human)
hsa-mir-450bGeneProductENSG00000216001 (Ensembl Human)
hsa-mir-497GeneProductENSG00000207791 (Ensembl Human)
hsa-mir-503GeneProductENSG00000208005 (Ensembl Human)
hsa-mir-542GeneProductENSG00000207784 (Ensembl Human)
hsa-mir-92aGeneProductENSG00000207968 (Ensembl Human)
hsa-mir-93GeneProductENSG00000207757 (Ensembl Human)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP1545"
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