DIV (Homo sapiens)

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8FGFR4FLNCMAPKAPK3RAPGEF2FGF19CACNA2D2FGF9FLNBE47LOW=MOD BAD PRHIGH=MOD BAD PRPDGFRACACNG3HIGH=BAD PRMAP3K2DUSP16PRKXLOW=BAD PREXPR NO PRCACNA2D3AdenylylgbDihydropyridine-Sensitive2+K+PTPCaM kinase2+aG2+Regulators of G-proteinCaCytosolic Ca2+ApoptosisNa+PhopholambanSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamPKC inhibitor Protein-1Repolarization2+K+2+MAPKDNADNA2+Gap Junctions (Connexins)Ca2+2+MAPKKCytosolic CaPKA InhibitorsbDNAJNKCaLPSCaNa+/Ca2+ ExchangerMAPKKKp53 signaling pathwaybbgGGProtein Kinase CCytosolarrestin/GRK2+P2+Calreticulin-CaCaSRDNAEpinephrineCaM kinasecAMPL-Type Ca2+ ChannelCalsequestrin S-CaProliferation, differentiationDNA damageAdrenergic ReceptorPTPbgCalsequestrin C-CaADP + PiCaNa+CyclasesGRKProliferation, differentiationG alpha i/o/zAdrenergic Receptorbg2+IP3 ReceptorsSignalingDNAJNK & p38 MAP kinase pathwayAdenylyl CyclasesPFKBP12Classical MAP kinase PathwayERK5 pathwayMKPWnt signaling pathwayCellConnexinHeteromeric G-proteinConnexinIP3 ReceptorsGbeta ArrestinPhosphatidylinositolsignaling systemarrestin/GRKSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressCalmodulin2+Protein Kinase ACaProliferation, inflammation, anti-apoptosisIP3Cap382+Proliferation, differentiation,inflammationProtein Kinase AM1 Muscarinic ReceptorTranscription factorsG alpha i/o/zPIP2K+Ca2+bMAPKKKKIP4DAGCycleNa+/K+ ATPaseNa2+CaDAGG2+IP3Cytosolic CaEpinephrineMembraneDepolarizationADP + PiMAP3K3MAP3K1GNAZPRKCGRYR1GJB1RAF1CAMK2Dmkk3CAMK2AFASLGRGS20elk-1PRKAR1BPRKCHNTF5ADCY9GJA3PTPN7RAP1APRKAR2APRKCDMAPKAPK5MAPKAPK2RGS2PRKAR1ATP53NLKRASGRP4cAMPTAOK1ATPADRA1DCALM2CX36NF1CASP9AKT1NGFBGJB5NR4A1RGS9PRKCZMAP3K8PRKCGCALRRASA2MAP3K7IP1MAP2K7fgfrCASP7PPM1BSTK3TRAF2HSPB2PLA2G10DAXXGJA1YWHAGANXA6ATF4RYR3GRK6PPP3CBSLC8A1PAK2GNB2ADRB3RGS14DUSP10ADCY3TRAF6GJB3MOSPPP3CAGNG12CASP3MAP3K7IP2TNFGJA4ARRB2PTPRRITPR1MAPK9CRKLPLA2G5ATF2CACNA1SGNAI3GRK5HSPA1ACASP1RASA1PTPN5CAMK1ADRA1AMAXCALM3PRKACBAKT2ATPCASP2FGF4EGFRKRASIL1R2ATP2B3ADCY5PLCB3PRKCDITPR2MAPTMAPK4MAPK3GCKMAPK14PPP3CCGNGT1RPS6KA3CDC42RGS1HSPA8msk1/2FASATP2A2ECSITADCY6PRKACAKCNJ5GJB6PLNPTPN5ELK1GNA12MYCRYR2CRKsap1aIKBKGTMEM37GNG7RGS17RGS11SRFJUNDCASQ2RGS19FOSGJA6CD14MAP3K11ATP1B3PKIGAcetylcholineCAMK2BCASP8DDIT3PTPRRMAPK8IKBKBMAP3K7RASGRP1ARRB1MAP4K4NRASTGFB3DUSP4GNASGNAI2GNG2KCNJ3IL1AGNB3RGS18AKT3MAP2K1ATP1A4GNA11ATF4GJA10GNB1ADRB2TGFB1PKIBPTPN7RAP1BATPYWHAZATPPAK1NTRK1MRASPPM1AGRB2MAP3K6PLCB3EGFMAP4K1RGS5GNG8GJA7FXYD2CASQ1DUSP7MAPK6HSPA5MAP3K5IL1R1ADCY7GJA12RAC1PRKCDADCY1ITPR3DUSP6GJB2MAP3K12MAP4K3PRKCAPRKD1CAMK2GPRKCHTAOK2ZAKPRKCQMAPK10GJA5PRKCB1GNB5MINK1MEF2CGJB4FKBP1ARAC2ATP1B1GNG4PRKCB1CDC25Bnfat2/4ADRA1BPDGFRBMAPK1CACNB1RGS16BDNFNFKB1MAP2K4DUSP5SLC8A3MAP2K5PRKCEMAP3K13RGS3GADD45ARGS7ATP2B2ATP1B2PRKACAELK4/Sap1aSTMN1CASP6CACNA1DRGS4PPP5CADRB1MAP2K1IP1ADCY4GNG13PDGFBGNB4PKIAMAPK12SFNARRB1RASGRF2MAP3K14YWHAHIL1BPPP3R1GJA8YWHAQYWHAEKCNB1TGFB2ARRB2PRKCZRGS6mnk1/2ADCY2GNAQCALM1BRAFMAPK7ADCY8MAPK8IP3MAP2K2GNAO1CAMK4JUNGNG3GNAI1DUSP1RGS10YWHABHSPB1CACNB3PRKAR2BGRK4PPP3R2MAPK13FLNAPRKCHSOS2GNG5ATP2B1ADPCACNA1CMAP2K6MAP3K4GNG11ATP2A3


Description

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Ontology Terms

 

Bibliography


History

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CompareRevisionActionTimeUserComment
40450view15:04, 28 February 2011AmcuserDeleted pathway: obsolete
37356view21:50, 30 May 2010AmcuserPeriodical save, work in progress
37355view21:39, 30 May 2010AmcuserPeriodical save, work in progress
37313view21:50, 26 May 2010AmcuserPeriodical save, work in progress
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37224view18:12, 22 May 2010AmcuserPeriodical save, work in progress
37223view18:02, 22 May 2010AmcuserNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProduct107 (Entrez Gene) CYA1 HUMAN
ADCY2GeneProduct108 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY3GeneProduct109 (Entrez Gene)
ADCY4GeneProduct196883 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY5GeneProduct111 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
ADCY6GeneProduct112 (Entrez Gene)
ADCY7GeneProduct113 (Entrez Gene)
ADCY8GeneProduct114 (Entrez Gene)
ADCY9GeneProduct115 (Entrez Gene)
ADPMetabolite58-64-0 (CAS)
ADRA1AGeneProduct148 (Entrez Gene)
ADRA1BGeneProduct147 (Entrez Gene)
ADRA1DGeneProduct146 (Entrez Gene)
ADRB1GeneProduct153 (Entrez Gene)
ADRB2GeneProduct154 (Entrez Gene) 5q31
ADRB3GeneProduct155 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ANXA6GeneProduct309 (Entrez Gene)
ARRB1GeneProduct408 (Entrez Gene)
ARRB2GeneProduct409 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene) 2q32
ATF4GeneProduct468 (Entrez Gene)
ATPMetabolite1927-31-7 (CAS)
ATP1A4GeneProduct480 (Entrez Gene)
ATP1B1GeneProduct481 (Entrez Gene)
ATP1B2GeneProduct482 (Entrez Gene)
ATP1B3GeneProduct483 (Entrez Gene)
ATP2A2GeneProduct488 (Entrez Gene)
ATP2A3GeneProduct489 (Entrez Gene)
ATP2B1GeneProduct490 (Entrez Gene)
ATP2B2GeneProduct491 (Entrez Gene)
ATP2B3GeneProduct492 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
BDNFGeneProduct627 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CACNA1CGeneProduct775 (Entrez Gene)
CACNA1DGeneProduct776 (Entrez Gene)
CACNA1SGeneProduct779 (Entrez Gene)
CACNB1GeneProduct782 (Entrez Gene)
CACNB3GeneProduct784 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
CALM2GeneProduct805 (Entrez Gene)
CALM3GeneProduct808 (Entrez Gene)
CALRGeneProduct811 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CAMK2BGeneProduct816 (Entrez Gene) 22q12, 7p14, regulates c-FLIP
CAMK2DGeneProduct817 (Entrez Gene)
CAMK2GGeneProduct818 (Entrez Gene) 10q22
CAMK4GeneProduct814 (Entrez Gene)
CASP1GeneProduct834 (Entrez Gene)
CASP2GeneProduct835 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene) 4q34
CASP6GeneProduct839 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CASQ1GeneProduct844 (Entrez Gene)
CASQ2GeneProduct845 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene) 1p 22.2 MB
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CX36GeneProduct57369 (Entrez Gene)
DAXXGeneProduct1616 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
DUSP10GeneProduct11221 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
DUSP4GeneProduct1846 (Entrez Gene)
DUSP5GeneProduct1847 (Entrez Gene)
DUSP6GeneProduct1848 (Entrez Gene)
DUSP7GeneProduct1849 (Entrez Gene)
ECSITGeneProduct51295 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ELK4/Sap1aGeneProduct
FASGeneProduct355 (Entrez Gene)
FASLGGeneProduct356 (Entrez Gene)
FGF4GeneProduct2249 (Entrez Gene)
FKBP1AGeneProduct2280 (Entrez Gene) 20p13
FLNAGeneProduct2316 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FXYD2GeneProduct486 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GCKGeneProduct2645 (Entrez Gene)
GJA10GeneProduct81025 (Entrez Gene)
GJA12GeneProduct57165 (Entrez Gene)
GJA1GeneProduct2697 (Entrez Gene)
GJA3GeneProduct2700 (Entrez Gene)
GJA4GeneProduct2701 (Entrez Gene)
GJA5GeneProduct2702 (Entrez Gene)
GJA6GeneProduct
GJA7GeneProduct10052 (Entrez Gene)
GJA8GeneProduct2703 (Entrez Gene)
GJB1GeneProduct2705 (Entrez Gene)
GJB2GeneProduct2706 (Entrez Gene)
GJB3GeneProduct2707 (Entrez Gene)
GJB4GeneProduct127534 (Entrez Gene)
GJB5GeneProduct2709 (Entrez Gene)
GJB6GeneProduct10804 (Entrez Gene)
GNA11GeneProduct2767 (Entrez Gene) 7q21
GNA12GeneProduct2768 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAI3GeneProduct2773 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene) 9q21
GNASGeneProduct2778 (Entrez Gene)
GNAZGeneProduct2781 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNB2GeneProduct2783 (Entrez Gene)
GNB3GeneProduct2784 (Entrez Gene)
GNB4GeneProduct59345 (Entrez Gene)
GNB5GeneProduct10681 (Entrez Gene) 15q21
GNG11GeneProduct2791 (Entrez Gene)
GNG12GeneProduct55970 (Entrez Gene)
GNG13GeneProduct51764 (Entrez Gene)
GNG2GeneProduct54331 (Entrez Gene) 14q21
GNG3GeneProduct2785 (Entrez Gene)
GNG4GeneProduct2786 (Entrez Gene)
GNG5GeneProduct2787 (Entrez Gene)
GNG7GeneProduct2788 (Entrez Gene)
GNG8GeneProduct94235 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GRK4GeneProduct2868 (Entrez Gene)
GRK5GeneProduct2869 (Entrez Gene)
GRK6GeneProduct2870 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
HSPA8GeneProduct3312 (Entrez Gene) 11q24
HSPB1GeneProduct3315 (Entrez Gene)
HSPB2GeneProduct3316 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
IL1R2GeneProduct7850 (Entrez Gene)
ITPR1GeneProduct3708 (Entrez Gene)
ITPR2GeneProduct3709 (Entrez Gene)
ITPR3GeneProduct3710 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene) 1p 59 Mb
JUNDGeneProduct3727 (Entrez Gene)
KCNB1GeneProduct3745 (Entrez Gene)
KCNJ3GeneProduct3760 (Entrez Gene)
KCNJ5GeneProduct3762 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K1IP1GeneProduct8649 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene) 17p11
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K3GeneProduct171492 (Entrez Gene) 17q23
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K7IP1GeneProduct10454 (Entrez Gene)
MAP3K7IP2GeneProduct23118 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene) 2p22
MAP4K4GeneProduct9448 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene) 22q11
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene) JNK1, 10q11
MAPK8IP3GeneProduct23162 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MAPKAPK5GeneProduct8550 (Entrez Gene)
MAPTGeneProduct4137 (Entrez Gene)
MAXGeneProduct4149 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
MOSGeneProduct4342 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NF1GeneProduct4763 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NGFBGeneProduct4803 (Entrez Gene)
NLKGeneProduct51701 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
NTF5GeneProduct4909 (Entrez Gene)
NTRK1GeneProduct4914 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PKIAGeneProduct5569 (Entrez Gene) 8q21
PKIBGeneProduct5570 (Entrez Gene)
PKIGGeneProduct11142 (Entrez Gene)
PLA2G10GeneProduct8399 (Entrez Gene)
PLA2G5GeneProduct5322 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
PLNGeneProduct5350 (Entrez Gene)
PPM1AGeneProduct5494 (Entrez Gene)
PPM1BGeneProduct5495 (Entrez Gene) 2p21
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene) 10q21
PPP3CCGeneProduct5533 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PPP3R2GeneProduct5535 (Entrez Gene)
PPP5CGeneProduct5536 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACBGeneProduct5567 (Entrez Gene) 1p36, 82.2 MB
PRKAR1AGeneProduct5573 (Entrez Gene) KAP0 HUMAN
PRKAR1BGeneProduct5575 (Entrez Gene)
PRKAR2AGeneProduct5576 (Entrez Gene)
PRKAR2BGeneProduct5577 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCEGeneProduct5581 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PRKCGGeneProduct5582 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene) 1p36, 1.88 MB
PRKD1GeneProduct5587 (Entrez Gene) KPCM HUMAN
PTPN5GeneProduct84867 (Entrez Gene)
PTPN7GeneProduct5778 (Entrez Gene)
PTPRRGeneProduct5801 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RASA2GeneProduct5922 (Entrez Gene)
RASGRF2GeneProduct5924 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RASGRP4GeneProduct115727 (Entrez Gene)
RGS10GeneProduct6001 (Entrez Gene)
RGS11GeneProduct8786 (Entrez Gene)
RGS14GeneProduct10636 (Entrez Gene)
RGS1GeneProduct5996 (Entrez Gene)
RGS16GeneProduct6004 (Entrez Gene)
RGS17GeneProduct26575 (Entrez Gene)
RGS18GeneProduct64407 (Entrez Gene)
RGS19GeneProduct10287 (Entrez Gene)
RGS20GeneProduct8601 (Entrez Gene)
RGS2GeneProduct5997 (Entrez Gene)
RGS3GeneProduct5998 (Entrez Gene)
RGS4GeneProduct5999 (Entrez Gene)
RGS5GeneProduct8490 (Entrez Gene)
RGS6GeneProduct9628 (Entrez Gene)
RGS7GeneProduct6000 (Entrez Gene) 1q23, 1q42
RGS9GeneProduct8787 (Entrez Gene) 17q23-24
RPS6KA3GeneProduct6197 (Entrez Gene)
RYR1GeneProduct6261 (Entrez Gene)
RYR2GeneProduct6262 (Entrez Gene)
RYR3GeneProduct6263 (Entrez Gene)
SFNGeneProduct2810 (Entrez Gene)
SLC8A1GeneProduct6546 (Entrez Gene)
SLC8A3GeneProduct6547 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene) 14q21
SRFGeneProduct6722 (Entrez Gene)
STK3GeneProduct6788 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
TAOK1GeneProduct57551 (Entrez Gene)
TAOK2GeneProduct9344 (Entrez Gene) TAOK2= TAO Kinase, ser Thr kinase, binds microtubules, JNK and CASP mediates removal microtub-binding domain, nuclear transloc of TAOK2 and induction of apoptosis
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TMEM37GeneProduct140738 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TRAF2GeneProduct7186 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
YWHABGeneProduct7529 (Entrez Gene)
YWHAEGeneProduct7531 (Entrez Gene)
YWHAGGeneProduct7532 (Entrez Gene)
YWHAHGeneProduct7533 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene) PMID: 9861170 PMID: 1317796
ZAKGeneProduct51776 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
elk-1GeneProduct
fgfrGeneProduct
mkk3GeneProduct
mnk1/2GeneProduct
msk1/2GeneProduct
nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP1540"
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