Valine, leucine and isoleucine degradation (Caenorhabditis elegans)

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Pyrimidine metabolismBiosynthesis of type II polyketide backbonePropanoate metabolismBiosynthesis of steroidsCitrate cycle (TCA cycle)Valine, leucine and isoleucine biosynthesisBiosynthesis of 12-, 14- and 16-membered macrolidesThiamin diphosphatehypothetical protein alh-8L-IsoleucineEnzyme N6-(lipoyl)lysine3-Methylbutanoyl-CoAacdh-7acdh-8ko:K00157(S)-3-Methyl-2-oxopentanoic acidech-3Lipoamide-EAcetyl-CoALLC1.3ech-1ech-6tag-173Methylmalonateech-3ech-6L-3-Amino-isobutanoateTransketolasehypothetical protein L-Leucinetag-173ko:K00186 ko:K00187 ko:K00189 ko:K00188acdh-8acdh-72-Methylpropanoyl-CoAhypothetical protein ko:K00186 ko:K00187 ko:K00189 ko:K00188acdh-10ech-1ech-8ko:K00186 ko:K00187 ko:K00189 ko:K00188ko:K00822ec:2.6.1.6hypothetical protein mmcm-1Transketolasehypothetical protein Enzyme N6-(dihydrolipoyl)lysinecpd:C06000(R)-Methylmalonyl-CoAech-2hypothetical protein [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysineTransketolasealh-9kat-1ech-9ech-5Transketolasehypothetical protein Isobutyryl-CoAacdh-10ko:K00186 ko:K00187 ko:K00189 ko:K00188ech-2hypothetical protein beta-Ketoisocaproateech-73-Methylglutaconyl-CoAY44A6D.5(S)-3-Hydroxy-3-methylglutaryl-CoA2-Methylbut-2-enoyl-CoA(S)-Methylmalonyl-CoATransketolase[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysineech-7hypothetical protein hypothetical protein tag-173hypothetical protein ZK669.4cpd:C06001cpd:C06002T08B2.7ko:K00248Propanoyl-CoAhypothetical protein ech-1ech-8ard-1hypothetical protein hypothetical protein hypothetical protein bcat-1ech-9hypothetical protein ivd-1ko:K05607ard-1Enzyme N6-(dihydrolipoyl)lysinehypothetical protein ko:K00186 ko:K00187 ko:K00189 ko:K00188L-Valinetag-173(3R)-beta-Leucineko:K00186 ko:K00187 ko:K00189 ko:K00188alh-1ech-7Succinyl-CoAacdh-8Thiolasesech-5Methacrylyl-CoAech-2hypothetical protein ko:K00186 ko:K00187 ko:K00189 ko:K00188Dihydrolipoamide-EGeneProducthypothetical protein 2-Methylacetoacetyl-CoA(S)-3-Hydroxyisobutyryl-CoAko:K00186 ko:K00187 ko:K00189 ko:K00188pccb-1bcat-1(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoAEnzyme N6-(lipoyl)lysineko:K00186 ko:K00187 ko:K00189 ko:K00188cpd:C159803-Methyl-2-oxobutanoic acidko:K00248ech-5Enzyme N6-(lipoyl)lysine[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine4-Methyl-2-oxopentanoateech-6cpd:C05996acdh-102-Methyl-1-hydroxypropyl-ThPPko:K05605ec:5.4.3.7ech-3ard-1ko:K05606ko:K00186 ko:K00187 ko:K00189 ko:K00188acdh-3ko:K00263ko:K00186 ko:K00187 ko:K00189 ko:K00188tag-173ko:K07250ko:K00186 ko:K00187 ko:K00189 ko:K00188ech-13-Methyl-1-hydroxybutyl-ThPPThiamin diphosphateko:K11538hypothetical protein hypothetical protein Thiamin diphosphate3-Hydroxyisovaleryl-CoAhacd-1Acetoacetyl-CoAEnzyme N6-(dihydrolipoyl)lysinehacd-1tag-1733-Methylcrotonyl-CoA2-Methylprop-2-enoyl-CoAbcat-1acdh-3pcca-1S-(2-Methylpropionyl)-dihydrolipoamide-Ehypothetical protein Transketolasealh-2acdh-72-Methyl-1-hydroxybutyl-ThPPko:K00263ko:K03334hypothetical protein hypothetical protein hypothetical protein hypothetical protein TransketolaseAcetoacetatehypothetical protein


Description

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History

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CompareRevisionActionTimeUserComment
34744view22:49, 13 January 2010KhanspersDeleted pathway: duplicate
33726view15:41, 8 December 2009Pieter Giesbertzfixed datapoints from KEGG
33725view15:29, 8 December 2009Pieter GiesbertzPeriodical save, work in progress
33724view15:19, 8 December 2009Pieter GiesbertzPeriodical save, work in progress
33723view15:09, 8 December 2009Pieter GiesbertzPeriodical save, work in progress
33722view14:59, 8 December 2009Pieter Giesbertzmanually improving KEGG pathway
33719view13:39, 8 December 2009Pieter Giesbertzmanually improving KEGG pathway
33718view12:48, 8 December 2009Pieter GiesbertzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoAMetaboliteC04405 (Kegg Compound)
(3R)-beta-LeucineMetaboliteC02486 (Kegg Compound)
(R)-Methylmalonyl-CoAMetaboliteC01213 (Kegg Compound)
(S)-3-Hydroxy-3-methylglutaryl-CoAMetaboliteC00356 (Kegg Compound)
(S)-3-Hydroxyisobutyryl-CoAMetaboliteHMDB01052 (HMDB)
(S)-3-Methyl-2-oxopentanoic acidMetaboliteC00671 (Kegg Compound)
(S)-Methylmalonyl-CoAMetaboliteC00683 (Kegg Compound)
2-Methyl-1-hydroxybutyl-ThPPMetaboliteC15978 (Kegg Compound)
2-Methyl-1-hydroxypropyl-ThPPMetaboliteC15976 (Kegg Compound)
2-Methylacetoacetyl-CoAMetaboliteC03344 (Kegg Compound)
2-Methylbut-2-enoyl-CoAMetaboliteC03345 (Kegg Compound)
2-Methylprop-2-enoyl-CoAMetaboliteC03460 (Kegg Compound)
2-Methylpropanoyl-CoAMetaboliteC00630 (Kegg Compound)
3-Hydroxyisovaleryl-CoAMetaboliteC05998 (Kegg Compound)
3-Methyl-1-hydroxybutyl-ThPPMetaboliteC15974 (Kegg Compound)
3-Methyl-2-oxobutanoic acidMetaboliteC00141 (Kegg Compound)
3-Methylbutanoyl-CoAMetaboliteC02939 (Kegg Compound)
3-Methylcrotonyl-CoAMetaboliteC03069 (Kegg Compound)
3-Methylglutaconyl-CoAMetaboliteC03231 (Kegg Compound)
4-Methyl-2-oxopentanoateMetaboliteC00233 (Kegg Compound)
AcetoacetateMetaboliteC00164 (Kegg Compound)
Acetoacetyl-CoAMetaboliteC00332 (Kegg Compound)
Acetyl-CoAMetaboliteC00024 (Kegg Compound)
Dihydrolipoamide-EMetaboliteHMDB06879 (HMDB)
Enzyme N6-(dihydrolipoyl)lysineMetaboliteC15973 (Kegg Compound)
Enzyme N6-(lipoyl)lysineMetaboliteC15972 (Kegg Compound)
GeneProductGeneProduct
Isobutyryl-CoAMetaboliteHMDB01243 (HMDB)
L-3-Amino-isobutanoateMetaboliteC03284 (Kegg Compound)
L-IsoleucineMetaboliteC00407 (Kegg Compound)
L-LeucineMetaboliteC00123 (Kegg Compound)
L-ValineMetaboliteC00183 (Kegg Compound)
LLC1.3GeneProductLLC1.3 (Ensembl C. elegans)
Lipoamide-EMetaboliteHMDB06877 (HMDB)
Methacrylyl-CoAMetaboliteHMDB01011 (HMDB)
MethylmalonateMetaboliteC02170 (Kegg Compound)
Propanoyl-CoAMetaboliteC00100 (Kegg Compound)
S-(2-Methylpropionyl)-dihydrolipoamide-EMetaboliteHMDB06868 (HMDB)
Succinyl-CoAMetaboliteC00091 (Kegg Compound)
T08B2.7GeneProductT08B2.7 (Ensembl C. elegans)
Thiamin diphosphateMetaboliteC00068 (Kegg Compound)
ThiolasesGeneProductF53A2.7 (WormBase)

Original kegg element: gene;38;cel:B0303.3 cel:F53A2.7

TransketolaseGeneProductY39E4A.3 (WormBase) Original kegg element: gene;12;cel:F27D4.5 cel:Y39E4A.3
Y44A6D.5GeneProduct180361 (Entrez Gene)
ZK669.4GeneProduct174279 (Entrez Gene)
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysineMetaboliteC15979 (Kegg Compound)
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysineMetaboliteC15977 (Kegg Compound)
[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysineMetaboliteC15975 (Kegg Compound)
acdh-10GeneProductT08G2.3 (WormBase)

Original kegg element: gene;69;cel:K05F1.3 cel:K09H11.1 cel:T08G2.3 cel:T25G12.5

acdh-3GeneProductK06A5.6 (WormBase)

Original kegg element: gene;59;cel:K06A5.6

acdh-7GeneProductT25G12.5 (WormBase)

Original kegg element: gene;69;cel:K05F1.3 cel:K09H11.1 cel:T08G2.3 cel:T25G12.5

acdh-8GeneProductK05F1.3 (WormBase)

Original kegg element: gene;69;cel:K05F1.3 cel:K09H11.1 cel:T08G2.3 cel:T25G12.5

alh-1GeneProductF54D8.3 (WormBase)

Original kegg element: gene;50;cel:F01F1.6 cel:F54D8.3 cel:K04F1.15

alh-2GeneProductK04F1.15 (WormBase)

Original kegg element: gene;50;cel:F01F1.6 cel:F54D8.3 cel:K04F1.15

alh-8GeneProductF13D12.4 (WormBase)

Original kegg element: gene;51;cel:F13D12.4

alh-9GeneProductF01F1.6 (WormBase)

Original kegg element: gene;50;cel:F01F1.6 cel:F54D8.3 cel:K04F1.15

ard-1GeneProductF01G4.2 (WormBase)

Original kegg element: gene;56;cel:F01G4.2

bcat-1GeneProductK02A4.1 (WormBase)

Original kegg element: gene;63;cel:K02A4.1 cel:Y44A6D.5

beta-KetoisocaproateMetaboliteC03467 (Kegg Compound)
cpd:C05996MetaboliteC05996 (Kegg Compound)
cpd:C06000MetaboliteC06000 (Kegg Compound)
cpd:C06001MetaboliteC06001 (Kegg Compound)
cpd:C06002MetaboliteC06002 (Kegg Compound)
cpd:C15980MetaboliteC15980 (Kegg Compound)
ec:2.6.1.6GeneProduct2.6.1.6 (Kegg enzyme)
ec:5.4.3.7GeneProduct5.4.3.7 (Kegg enzyme)
ech-1GeneProductC29F3.1 (WormBase)
ech-2GeneProductF38H4.8 (WormBase)

Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4

ech-3GeneProductF43H9.1 (WormBase)

Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4

ech-5GeneProductF56B3.5 (WormBase)

Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4

ech-6GeneProductT05G5.6 (WormBase)

Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4

ech-7GeneProductY105E8A.4 (WormBase)

Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4

ech-8GeneProductF01G10.2 (WormBase)

Original kegg element: gene;53;cel:B0272.3 cel:F01G10.2 cel:F01G10.3 cel:F01G4.2 cel:F54C8.1 cel:R09B5.6

ech-9GeneProductF01G10.3 (WormBase)

Original kegg element: gene;53;cel:B0272.3 cel:F01G10.2 cel:F01G10.3 cel:F01G4.2 cel:F54C8.1 cel:R09B5.6

hacd-1GeneProductR09B5.6 (WormBase)

Original kegg element: gene;53;cel:B0272.3 cel:F01G10.2 cel:F01G10.3 cel:F01G4.2 cel:F54C8.1 cel:R09B5.6

hypothetical protein GeneProductB0250.5 (WormBase)

Original kegg element: gene;54;cel:B0250.5

hypothetical protein GeneProductB0272.3 (WormBase)

Original kegg element: gene;53;cel:B0272.3 cel:F01G10.2 cel:F01G10.3 cel:F01G4.2 cel:F54C8.1 cel:R09B5.6

hypothetical protein GeneProductB0303.3 (WormBase)

Original kegg element: gene;38;cel:B0303.3 cel:F53A2.7

hypothetical protein GeneProductC05C10.3 (WormBase)

Original kegg element: gene;28;cel:C05C10.3

hypothetical protein GeneProductF25B4.6 (WormBase)

Original kegg element: gene;27;cel:F25B4.6

hypothetical protein GeneProductF32B6.2 (WormBase)

Original kegg element: gene;31;cel:F32B6.2

hypothetical protein GeneProductF54C8.1 (WormBase)

Original kegg element: gene;53;cel:B0272.3 cel:F01G10.2 cel:F01G10.3 cel:F01G4.2 cel:F54C8.1 cel:R09B5.6

hypothetical protein GeneProductK09H11.1 (WormBase)

Original kegg element: gene;69;cel:K05F1.3 cel:K09H11.1 cel:T08G2.3 cel:T25G12.5

hypothetical protein GeneProductLLC1.3 (WormBase)

Original kegg element: gene;17;cel:LLC1.3

hypothetical protein GeneProductT02G5.4 (WormBase)

Original kegg element: gene;21;cel:T02G5.4 cel:T02G5.7 cel:T02G5.8

hypothetical protein GeneProductT02G5.7 (WormBase)

Original kegg element: gene;21;cel:T02G5.4 cel:T02G5.7 cel:T02G5.8

hypothetical protein GeneProductT08B2.7 (WormBase)

Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4

hypothetical protein GeneProductY44A6D.5 (WormBase)

Original kegg element: gene;63;cel:K02A4.1 cel:Y44A6D.5

hypothetical protein GeneProductY71G12B.10 (WormBase)

Original kegg element: gene;29;cel:Y71G12B.10

hypothetical protein GeneProductZK669.4 (WormBase)

Original kegg element: gene;62;cel:ZK669.4

ivd-1GeneProductC02B10.1 (WormBase)

Original kegg element: gene;33;cel:C02B10.1

kat-1GeneProductT02G5.8 (WormBase)

Original kegg element: gene;21;cel:T02G5.4 cel:T02G5.7 cel:T02G5.8

ko:K00157GeneProductK00157 (Kegg ortholog)
ko:K00186 ko:K00187 ko:K00189 ko:K00188GeneProductK00186... (Kegg ortholog)
ko:K00248GeneProductK00248 (Kegg ortholog)
ko:K00263GeneProductK00263 (Kegg ortholog)
ko:K00822GeneProductK00822 (Kegg ortholog)
ko:K03334GeneProductK03334 (Kegg ortholog)
ko:K05605GeneProductK05605 (Kegg ortholog)
ko:K05606GeneProductK05606 (Kegg ortholog)
ko:K05607GeneProductK05607 (Kegg ortholog)
ko:K07250GeneProductK07250 (Kegg ortholog)
ko:K11538GeneProductK11538 (Kegg ortholog)
mmcm-1GeneProductZK1058.1 (WormBase)

Original kegg element: gene;46;cel:ZK1058.1

pcca-1GeneProductF27D9.5 (WormBase)

Original kegg element: gene;48;cel:F27D9.5 cel:F52E4.1

pccb-1GeneProductF52E4.1 (WormBase)

Original kegg element: gene;48;cel:F27D9.5 cel:F52E4.1

tag-173GeneProductF27D4.5 (WormBase) Original kegg element: gene;43;cel:F27D4.5 cel:Y39E4A.3

Annotated Interactions

No annotated interactions

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