Arachidonate epoxygenase / epoxide hydrolase (Homo sapiens)

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1, 3-11, 14...Glutathionyl-HETrEsPhosphotidyl-EpETrEs8(9)-EpETrE5(6)-EpETrE5,6-DiHETrECOXArachidonic acidCOXCYP2C814(15)-EpETrEEPHX28,9-DiHETrE14,15-DiHETrE5,6-DiH-PGF1aCatalystEPHX2ProductEPHX2CYP2J2CYP2C911,12-DiHETrE5(6)-Epoxy-PGE1ProductEPHX2GST311(12)-EpETrE161, 111, 112, 12-1444, 1511424, 12


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Fatty Acid Epoxygenase
 
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Bibliography

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  1. Carroll MA, Schwartzman M, Sacerdoti D, McGiff JC; ''Novel renal arachidonate metabolites.''; Am J Med Sci, 1988 PubMed Europe PMC Scholia
  2. Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD; ''Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.''; Am J Physiol Heart Circ Physiol, 2006 PubMed Europe PMC Scholia
  3. Sarkis A, Roman RJ; ''Role of cytochrome P450 metabolites of arachidonic acid in hypertension.''; Curr Drug Metab, 2004 PubMed Europe PMC Scholia
  4. Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck JR, Miura H; ''Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors.''; Circ Res, 2008 PubMed Europe PMC Scholia
  5. Morisseau C, Hammock BD; ''Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical.''; Pest Manag Sci, 2008 PubMed Europe PMC Scholia
  6. Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, Nilius B; ''Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.''; Circ Res, 2005 PubMed Europe PMC Scholia
  7. Zhang L, Ding H, Yan J, Hui R, Wang W, Kissling GE, Zeldin DC, Wang DW; ''Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population.''; Pharmacogenet Genomics, 2008 PubMed Europe PMC Scholia
  8. Mannervik B, Board PG, Hayes JD, Listowsky I, Pearson WR; ''Nomenclature for mammalian soluble glutathione transferases.''; Methods Enzymol, 2005 PubMed Europe PMC Scholia
  9. Newman JW, Morisseau C, Hammock BD; ''Epoxide hydrolases: their roles and interactions with lipid metabolism.''; Prog Lipid Res, 2005 PubMed Europe PMC Scholia
  10. Oliw EH; ''Biosynthesis of 5,6-dihydroxyprostaglandin E1 and F1 alpha from 5,6-dihydroxyeicosatrienoic acid by ram seminal vesicles.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  11. Harder DR, Roman RJ, Gebremedhin D; ''Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes.''; Acta Physiol Scand, 2000 PubMed Europe PMC Scholia
  12. Oliw EH, Benthin G; ''On the metabolism of epoxyeicosatrienoic acids by ram seminal vesicles: isolation of 5(6)epoxy-prostaglandin F1 alpha.''; Biochem Biophys Res Commun, 1985 PubMed Europe PMC Scholia
  13. Capdevila JH, Kishore V, Dishman E, Blair IA, Falck JR; ''A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs).''; Biochem Biophys Res Commun, 1987 PubMed Europe PMC Scholia
  14. Spector AA, Fang X, Snyder GD, Weintraub NL; ''Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.''; Prog Lipid Res, 2004 PubMed Europe PMC Scholia
  15. Sacerdoti D, Gatta A, McGiff JC; ''Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.''; Prostaglandins Other Lipid Mediat, 2003 PubMed Europe PMC Scholia
  16. Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD; ''Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).''; Prostaglandins Other Lipid Mediat, 2007 PubMed Europe PMC Scholia
  17. Spearman ME, Prough RA, Estabrook RW, Falck JR, Manna S, Leibman KC, Murphy RC, Capdevila J; ''Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs).''; Arch Biochem Biophys, 1985 PubMed Europe PMC Scholia
  18. N�sing RM, Schweer H, Fleming I, Zeldin DC, Wegmann M; ''Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: dependence on cyclooxygenase and cell polarity.''; Am J Physiol Renal Physiol, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
142378view16:20, 30 January 2026DeSlOntology Term : 'classic metabolic pathway' added !
142377view16:19, 30 January 2026DeSlOntology Term : 'lipid metabolic pathway' added !
142376view16:19, 30 January 2026DeSlAnnotated missing metabolite ID
142337view12:12, 25 January 2026EgonwRemoved old comments
140958view22:55, 30 October 2025EweitzClear cached dimensions
140957view22:54, 30 October 2025EweitzEconomize layout
134379view15:44, 21 July 2024EweitzRemove template comments
126228view06:26, 17 April 2023EgonwLicense is CCZero
116938view10:02, 16 May 2021EweitzModified title
106822view13:30, 17 September 2019MaintBotHMDB identifier normalization
94200view14:48, 25 August 2017DeSlAdded ID for 5(6)-Epoxy-PGE1
71506view19:21, 17 October 2013MaintBotremoved data source from nodes without identifier
67058view10:00, 26 June 2013Christine ChichesterOntology Term : 'arachidonic acid metabolic pathway' added !
63166view20:24, 8 May 2013MaintBotUpdating GPML version
59189view19:02, 22 February 2013MaintBotUpdated Ensembl data source
44962view12:48, 6 October 2011MartijnVanIerselOntology Term : 'metabolic pathway of secondary metabolites' added !
41165view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
38950view00:05, 25 September 2010KhanspersChanged layout
38949view00:02, 25 September 2010Khanspers
33404view14:48, 30 November 2009MaintBotRemoved group label
30254view04:39, 25 July 2009AlexanderPicoModified categories
29908view12:13, 9 June 2009Thomasupdated ensembl references
29111view05:25, 3 April 2009JwnewmanModified description
29110view05:12, 3 April 2009JwnewmanPeriodical save, work in progress
28979view15:33, 19 March 2009EveloCorrecte COX annotation to something that *might* be right
28976view13:22, 19 March 2009EveloSpecify description
28975view13:18, 19 March 2009EveloPeriodical save, work in progress
28974view13:08, 19 March 2009EveloPeriodical save, work in progress
28973view12:45, 19 March 2009MartijnVanIerselNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11(12)-EpETrEMetaboliteHMDB10409 (HMDB)
11,12-DiHETrEMetaboliteHMDB02314 (HMDB)
14(15)-EpETrEMetaboliteHMDB04264 (HMDB)
14,15-DiHETrEMetaboliteHMDB02265 (HMDB)
5(6)-EpETrEMetaboliteHMDB02190 (HMDB)
5(6)-Epoxy-PGE1Metabolite
5,6-DiH-PGF1aMetabolite
5,6-DiHETrEMetaboliteHMDB02343 (HMDB)
8(9)-EpETrEMetaboliteHMDB02232 (HMDB)
8,9-DiHETrEMetaboliteHMDB02311 (HMDB)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
COXGeneProductHMDB05033 (HMDB)
CYP2C8GeneProduct1558 (Entrez Gene)
CYP2C9GeneProduct1559 (Entrez Gene)
CYP2J2GeneProductENSG00000134716 (Ensembl)
CatalystGeneProduct
EPHX2GeneProduct2053 (Entrez Gene)
GST3GeneProduct2950 (Entrez Gene)
ProductMetabolite

Annotated Interactions

No annotated interactions
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