SNARE complex machinery in exocytosis (Homo sapiens)

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Description

This is a mechanistic pathway for SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor) complex and its interactors in exocytosis.

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Ontology Terms

 

Bibliography

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  1. Fernández-Chacón R, Königstorfer A, Gerber SH, García J, Matos MF, Stevens CF, Brose N, Rizo J, Rosenmund C, Südhof TC; ''Synaptotagmin I functions as a calcium regulator of release probability.''; Nature, 2001 PubMed Europe PMC Scholia
  2. Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J; ''A conformational switch in syntaxin during exocytosis: role of munc18.''; EMBO J, 1999 PubMed Europe PMC Scholia
  3. Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R; ''The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  4. Lee S, Shin J, Jung Y, Son H, Jeong C, Kweon DH, Shin YK; ''Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.''; Sci Rep, 2020 PubMed Europe PMC Scholia
  5. Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J; ''Three-dimensional structure of the complexin/SNARE complex.''; Neuron, 2002 PubMed Europe PMC Scholia
  6. Tijerina X, Jabeena C, Faris R, Xu Z, Smith P, Schnicker NJ, Weber MM; ''CpoS-Inc interactions facilitate host cell modulation during Chlamydia trachomatis infection.''; Infect Immun, 2025 PubMed Europe PMC Scholia
  7. Scales SJ, Hesser BA, Masuda ES, Scheller RH; ''Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  8. Adams DJ, Arthur CP, Stowell MH; ''Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse.''; Sci Rep, 2015 PubMed Europe PMC Scholia
  9. Ullrich O, Stenmark H, Alexandrov K, Huber LA, Kaibuchi K, Sasaki T, Takai Y, Zerial M; ''Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  10. Shirataki H, Kaibuchi K, Sakoda T, Kishida S, Yamaguchi T, Wada K, Miyazaki M, Takai Y; ''Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.''; Mol Cell Biol, 1993 PubMed Europe PMC Scholia
  11. Ubach J, García J, Nittler MP, Südhof TC, Rizo J; ''Structure of the Janus-faced C2B domain of rabphilin.''; Nat Cell Biol, 1999 PubMed Europe PMC Scholia
  12. Kaeser PS, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Südhof TC; ''RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.''; Cell, 2011 PubMed Europe PMC Scholia
  13. Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N; ''Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming.''; Neuron, 2001 PubMed Europe PMC Scholia
  14. Persoon CM, Hoogstraaten RI, Nassal JP, van Weering JRT, Kaeser PS, Toonen RF, Verhage M; ''The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators.''; Neuron, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
142550view09:12, 21 March 2026EgonwTrEMBL datasources
142549view09:10, 21 March 2026EgonwCa²⁺ with unicode
142494view14:09, 10 March 2026DuanModified description
142493view14:08, 10 March 2026DuanModified title
142492view14:07, 10 March 2026DuanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CACNA1AGeneProductENSG00000141837 (Ensembl)
CACNA1BGeneProductENSG00000148408 (Ensembl)
CPLX1GeneProductENSG00000168993 (Ensembl) Complexin 1
Ca²⁺MetaboliteCHEBI:29108 (ChEBI)
GDI1GeneProductENSG00000203879 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI) Activate RAB
MUNC13-1ProteinQ9UPW8 (Uniprot-SwissProt)
MUNC18-1ProteinP61764 (Uniprot-SwissProt)
NAPAGeneProductENSG00000105402 (Ensembl)
NSFGeneProductENSG00000073969 (Ensembl)
RAB3AGeneProductENSG00000105649 (Ensembl) Most abundant isoform
RIMS1GeneProductENSG00000079841 (Ensembl)
RPH3AGeneProductENSG00000089169 (Ensembl)
SNAP25GeneProductENSG00000132639 (Ensembl)
STX1BGeneProductENSG00000099365 (Ensembl)
STXBP1GeneProductENSG00000136854 (Ensembl)
STXBP5GeneProductENSG00000164506 (Ensembl)
STXBP6GeneProductENSG00000168952 (Ensembl)
SYPGeneProductENSG00000102003 (Ensembl)
SYT1GeneProductENSG00000067715 (Ensembl)
UNC13AGeneProductENSG00000130477 (Ensembl)
VAMP2GeneProductENSG00000220205 (Ensembl) VAMP1 is dominant in spinal cord, VAMP2 is more expressed in brain neurons.

Annotated Interactions

No annotated interactions

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