Mitochondrial fatty acid synthesis pathway (Apis cerana)

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Description

Schematic presentation of the sequence of events. The indicated abbreviations follow the nomenclature used for the human enzymes and proteins. ACC, acetyl-CoA carboxylase; MCT, malonyl-CoA transferase; ACP, acyl-carrier protein; KAS, ketoacyl synthase; KAR, ketoacyl reductase; HTD2, hydroxyacyl-thioester reductase type 2; ETR, enoyl-thioester reductase. [J. Kastaniotis et al 2010] The original pathway (https://www.wikipathways.org/pathways/WP4317) was lifted into Apis cerana.

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Ontology Terms

 

Bibliography

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  1. Gabriel JL, Zervos PR, Plaut GW; ''Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.''; Metabolism, 1986 PubMed Europe PMC Scholia
  2. Hiltunen JK, Autio KJ, Schonauer MS, Kursu VA, Dieckmann CL, Kastaniotis AJ; ''Mitochondrial fatty acid synthesis and respiration.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  3. Lawson AM, Chalmers RA, Watts RW; ''Urinary organic acids in man. I. Normal patterns.''; Clin Chem, 1976 PubMed Europe PMC Scholia
  4. Greksák M, Lopes-Cardozo M, van den Bergh SG; ''Citrate synthesis in intact rat-liver mitochondria is irreversible.''; Eur J Biochem, 1982 PubMed Europe PMC Scholia
  5. Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL; ''Mitochondrial fatty acid synthesis type II: more than just fatty acids.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  6. Kakeru Yokoi, Masatsugu Hatakeyama, Seigo Kuwazaki, Taro Maeda, Mikio Yoshiyama, Mari Horigane-Ogihara, Shigeru Matsuyama, Akiya Jouraku, Hidemasa Bono, Kiyoshi Kimura; ''Comprehensive expression data for two honey bee species, Apis mellifera and Apis cerana japonica''; Scientific Data, 2025 DOI Scholia
  7. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS; ''Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.''; Proc Natl Acad Sci U S A, 1993 PubMed Europe PMC Scholia
  8. Des Rosiers C, Fernandez CA, David F, Brunengraber H; ''Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  9. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  10. Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.''; Ann N Y Acad Sci, 1999 PubMed Europe PMC Scholia
  11. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C; ''Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.''; Am J Physiol Heart Circ Physiol, 2002 PubMed Europe PMC Scholia
  12. Fernandez CA, Des Rosiers C; ''Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  13. Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.''; Biochem J, 1952 PubMed Europe PMC Scholia
  14. Johnson JD, Muhonen WW, Lambeth DO; ''Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  15. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  16. Hoek JB, Rydström J; ''Physiological roles of nicotinamide nucleotide transhydrogenase.''; Biochem J, 1988 PubMed Europe PMC Scholia
  17. Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.''; FEBS Lett, 1994 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
142544view10:04, 16 March 2026Kotaro470change author
142538view09:55, 16 March 2026Kotaro470change the organism
142526view02:44, 16 March 2026Kotaro470Modified title
142522view10:51, 13 March 2026Kotaro470New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3-Hydroxyacyl-ACP MetaboliteCHEBI:57318 (ChEBI)
3-Ketoacyl-ACPMetaboliteCHEBI:57347 (ChEBI)
ACACAGeneProductSTRG.2776.2 (Other)
ACACAGeneProductSTRG.2776.7 (Other)
ATPMetaboliteHMDB0000538 (HMDB) The ChEBI ID with the correct charge is: 30616
Acetyl-CoAMetaboliteHMDB0001206 (HMDB) The ChEBI ID with the correct charge is: 57288
Acetyl/Acyl-ACP MetaboliteQ59811305 (Wikidata)
Acyl-ACP Metabolite
CO₂MetaboliteHMDB0001967 (HMDB)
H MetaboliteCHEBI:15378 (ChEBI)
HSD17B12GeneProductSTRG.6101.2 (Other)
HSD17B12GeneProductSTRG.817.1 (Other)
HSD17B12GeneProductSTRG.817.2 (Other)
HSD17B12GeneProductSTRG.817.3 (Other)
HTD2 GeneProductSTRG.9051.11 (Other)
KASGeneProductSTRG.10815.2 (Other)
MCATGeneProductg183.t1 (Other)
MECRGeneProductSTRG.7874.5 (Other)
Malonyl-ACP MetaboliteC01209 (KEGG Compound)
Malonyl-CoAMetaboliteHMDB0001175 (HMDB)
Medium/Long-chain fatty acids Metabolite
NADPHMetaboliteHMDB0000221 (HMDB) The ChEBI ID with the correct charge is: 57783
NADPMetaboliteHMDB0000217 (HMDB)
Octanoyl-ACP MetaboliteCHEBI:7725 (ChEBI)
Trans-2-enoyl-ACP MetaboliteC05748 (KEGG Compound)
waterMetaboliteHMDB0002111 (HMDB)

Annotated Interactions

No annotated interactions

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