Diclofenac metabolic pathway (Bos taurus)

Revision as of 07:01, 22 February 2026 by Egonw (Talk | contribs)

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Description

CYP metabolism of the diclofenac drug (a NSAID), commonly used to treat pain and inflammatory diseases.

HomologyConvert: This pathway was inferred from Homo sapiens pathway WP2491(73891) with a 66.0% conversion rate.

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Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J; ''Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.''; Biochem Pharmacol, 1999 PubMed Europe PMC Scholia

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Name	Type	Database reference	Comment
3'-Hydroxydiclofenac	Metabolite	112230 (PubChem-compound)
4',5-Dihydroxydiclofenac	Metabolite	3052567 (PubChem-compound)
4'-hydroxydiclofenac	Metabolite	116545 (PubChem-compound)
5-hydroxydiclofenac	Metabolite	3052566 (PubChem-compound)
CYP2B6	Protein	ENSBTAG00000003871 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P20813
CYP2C18	Protein	ENSBTAG00000020375 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33260
CYP2C19	Protein	ENSBTAG00000020375 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33261
CYP2C8	Protein	ENSBTAG00000020375 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10632
CYP2C9	Protein
Metabolite	Metabolite	10065052 (PubChem-compound)
diclofenac	Metabolite	3033 (PubChem-compound)

No annotated interactions

Revision	Action	Time	User	Comment
142463	view	07:01, 22 February 2026	Egonw	Modified description
117495	view	11:03, 21 May 2021	Eweitz	Modified title
80717	view	15:23, 30 June 2015	Mkutmon	New pathway