Hypoxia-mediated EMT and stemness (Homo sapiens)

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Description

Model of hypoxia mediated EMT and stemness, involving DICER1 and ZEB1. DICER1 is inhibited by hypoxia which affects the maturing of miRNA.

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van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MH, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG; ''Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.''; Nat Commun, 2014 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
142459	view	20:36, 19 February 2026	Egonw	Modified description
142458	view	16:50, 18 February 2026	Egonw	Modified description
142025	view	13:26, 29 November 2025	Eweitz	Fix truncated text
142024	view	13:26, 29 November 2025	Eweitz	Economize layout
128729	view	02:51, 21 February 2024	Eweitz	Upgrade disease node, economize layout, standardize case
117758	view	12:53, 22 May 2021	Eweitz	Modified title
88661	view	15:19, 12 August 2016	Jmelius	Ontology Term : 'regulatory pathway' added !
83778	view	15:12, 4 December 2015	Susan	Add IDs miRNAs and changed miRNA names
81089	view	21:17, 21 July 2015	Khanspers
80336	view	22:30, 5 June 2015	Khanspers	Modified description
80335	view	22:28, 5 June 2015	Khanspers	New pathway

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Name	Type	Database reference
DICER1	GeneProduct	23405 (Entrez Gene)
Hypoxia		Q105688 (Wikidata)
ZEB1	GeneProduct	6935 (Entrez Gene)
hsa-miR-200a-3p	Rna	MIMAT0000682 (miRBase mature sequence)
hsa-miR-200b-3p	Rna	MIMAT0000318 (miRBase mature sequence)
hsa-miR-200c-3p	Rna	MIMAT0000617 (miRBase mature sequence)

No annotated interactions