Cholic acid-deoxycholic acid/ursocholic acid pathway: bile salt deconjugation, secondary bile acid synthesis, reconjugation and sulfation (Homo sapiens)
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Description
This pathway illustrates how gut microbiota remodel cholic acid (CA)–based bile salts through deconjugation, secondary bile acid synthesis, reconjugation and sulfation along the enterohepatic circulation. It includes bacterial bile salt hydrolase–mediated deconjugation, 7-dehydroxylation and epimerization reactions that generate secondary bile acids such as deoxycholic acid, as well as hepatic reconjugation and sulfation steps that shape bile acid solubility, toxicity and signaling potential in both humans and mice.
Abbreviation and Common Names for the given metabolites:
GCA-S: glycocholate 7-sulfate(2-)\ GCA: Glycocholic Acid\ TCA-S: Taurocholate 7-sulfate\ TCA: Taurocholic Acid CA: Cholic acid CA 7-sulfate: 7-Sulfocholic acid Phe-chol: Phe-chol Tyr-chol: Tyr-chol Leu-chol: Leu-chol 3-oxo-CA: 3-oxocholic acid Iso-CA: Isocholic acid KDCA: 7-oxodeoxycholic acid UCA: Ursocholic acid TUCA: Tauroursocholic acid GUCA: 3a,7b,12a-Trihydroxyoxocholanyl-Glycine 12-oxoCDCA: 12-oxoCDCA Epi-CA: 12-epicholic acid DCA: Deoxycholic acid Deoxycholyl-CoA: Deoxycholyl-CoA GDCA: Glycodeoxycholic acid GDCA-S: Glycodeoxycholate sulfate TDCA: Taurodeoxycholic acid TDCA-S: taurodeoxycholic acid 3-sulfate 12-oxo-LCA: 12-oxolithocholic acid Epi-DCA: Epideoxycholic acid 3-oxo-DCA: 12alpha-Hydroxy-3-oxo-5beta-cholan-24-oic Acid
Iso-DCA: Isodeoxycholic acidPlease use the New WikiPathways
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