Amino acid metabolism (Homo sapiens)

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Description

A complete overview of the metabolism of all 20 amino acids. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3925).

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP662 revision 71177, with a 99.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
140875view00:46, 30 October 2025EweitzClear deprecated metadata handling
137960view20:55, 10 March 2025KhanspersModified description
136171view14:20, 21 December 2024EgonwChanged to the ChEBI identifier
136170view12:28, 21 December 2024EgonwConverted labels into data nodes
136169view10:59, 21 December 2024EgonwConverted a metabolite Label to DataNode with identifier
136167view10:43, 21 December 2024EgonwThe linked ChEBI entry seems to have the correct stereochemistry
123124view18:51, 4 July 2022EgonwMade three pathways clickable
117062view14:23, 16 May 2021EweitzModified title
115752view11:42, 9 March 2021EgonwReplaced the WP id of a mouse pathway with the matching human pathway
107149view14:23, 17 September 2019MaintBotChEBI identifier normalization
106767view13:24, 17 September 2019MaintBotHMDB identifier normalization
105878view04:51, 16 August 2019KhanspersModified description
105525view05:59, 9 August 2019KhanspersModified description
96439view07:56, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
90737view23:26, 13 December 2016Khanspersupdated link to source pathway
90730view22:40, 13 December 2016KhanspersOntology Term : 'amino acid metabolic pathway' added !
90729view22:38, 13 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-oxo-glutarateMetaboliteCHEBI:16810 (ChEBI)
5-OH-TrpMetaboliteHMDB0000472 (HMDB)
AC007325.2GeneProductENSG00000277196 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125
AC068533.7GeneProductENSG00000249319 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084
ACAA1GeneProductENSG00000060971 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491
ACADMGeneProductENSG00000117054 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867
ACLYGeneProductENSG00000131473 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251
ACO2GeneProductENSG00000100412 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880
ACSS1GeneProductENSG00000154930 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988
ADH1CGeneProductENSG00000248144 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921
ADH4GeneProductENSG00000198099 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472
ADH5GeneProductENSG00000197894 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929
ADH7GeneProductENSG00000196344 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926
ALDH18A1GeneProductENSG00000059573 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908
ALDH1A1GeneProductENSG00000165092 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450
ALDH7A1GeneProductENSG00000164904 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186
AOC3GeneProductENSG00000131471 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797
AP002884.2GeneProductENSG00000255292 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175
ARG1GeneProductENSG00000118520 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070
ARG2GeneProductENSG00000081181 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806
ASNSGeneProductENSG00000070669 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929
ASS1GeneProductENSG00000130707 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090
AUHGeneProductENSG00000148090 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
AconitateMetaboliteHMDB0000072 (HMDB)
Ala-tRNAMetaboliteCHEBI:17732 (ChEBI)
AlanineMetaboliteHMDB0000161 (HMDB)
Arg-tRNAMetaboliteCHEBI:18366 (ChEBI)
ArginineMetaboliteHMDB0000517 (HMDB)
Arginino-succinateMetaboliteHMDB0000052 (HMDB)
AsparagineMetaboliteHMDB0000168 (HMDB)
AspartateMetaboliteHMDB0000191 (HMDB)
B-OH-butyrateMetaboliteHMDB0000011 (HMDB)
BCAT1GeneProductENSG00000060982 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861
BHMTGeneProductENSG00000145692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972
CADGeneProductENSG00000084774 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969
CBSGeneProductENSG00000160200 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285
CPS1GeneProductENSG00000021826 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996
CSGeneProductENSG00000062485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529
CTHGeneProductENSG00000116761 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968
Carbamoyl-aspartateMetaboliteHMDB0000828 (HMDB)
CitrateMetaboliteHMDB0000094 (HMDB)
CitrullineMetaboliteHMDB0000904 (HMDB)
Creatine PMetaboliteHMDB0001511 (HMDB)
CystathionineMetaboliteHMDB0000099 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DBHGeneProductENSG00000123454 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864
DDCGeneProductENSG00000132437 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876
DLDGeneProductENSG00000091140 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450
DLSTGeneProductENSG00000119689 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170
Dihydro-orotateMetaboliteHMDB0003349 (HMDB)
DopamineMetaboliteHMDB0000073 (HMDB)
EHHADHGeneProductENSG00000113790 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964
EPRSGeneProductENSG00000136628 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838
EpinephrineMetaboliteHMDB0000068 (HMDB)
EthanolMetaboliteHMDB0000108 (HMDB)
FAHGeneProductENSG00000103876 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482
FARSBGeneProductENSG00000116120 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035
FHGeneProductENSG00000091483 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194
FTCDGeneProductENSG00000160282 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962
Fatty acid metabolismPathwayWP357 (WikiPathways)
FumarateMetaboliteHMDB0000134 (HMDB)
G6PC2GeneProductENSG00000152254 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768
GCLMGeneProductENSG00000023909 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995
GLSGeneProductENSG00000115419 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752
GLUD1GeneProductENSG00000148672 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753
GLULGeneProductENSG00000135821 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739
GOT1GeneProductENSG00000120053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791
GOT2GeneProductENSG00000125166 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792
GPT2GeneProductENSG00000166123 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391
GSRGeneProductENSG00000104687 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804
GSSGeneProductENSG00000100983 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852
Glu-tRNAMetaboliteCHEBI:29157 (ChEBI)
GlucoseMetaboliteHMDB0000122 (HMDB)
GlutamateMetaboliteHMDB0000148 (HMDB)
GlutamineMetaboliteHMDB0000641 (HMDB)
GlycineMetaboliteHMDB0000123 (HMDB)
GstGeneProductNo homologues found for original id M:MGI:1309515
Guanidinoacetate PMetaboliteHMDB0003705 (HMDB)
GuanidinoacetateMetaboliteHMDB0000128 (HMDB)
HADHGeneProductENSG00000138796 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009
HALGeneProductENSG00000084110 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010
HCO3MetaboliteHMDB0003538 (HMDB)
HDCGeneProductENSG00000140287 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062
HIBADHGeneProductENSG00000106049 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802
HIBCHGeneProductENSG00000198130 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792
HMGCLGeneProductENSG00000117305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158
HMGCS2GeneProductENSG00000134240 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939
HNMTGeneProductENSG00000150540 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181
His-tRNAMetaboliteCHEBI:29155 (ChEBI)
HistamineMetaboliteHMDB0000870 (HMDB)
HistidineMetaboliteHMDB0000177 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
IARSGeneProductENSG00000196305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219
IDH1GeneProductENSG00000138413 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413
Ile-tRNAMetaboliteCHEBI:29160 (ChEBI)
Imidazole acetaldehydeMetaboliteHMDB0003905 (HMDB)
IndoleacetaldehydeMetaboliteHMDB0001190 (HMDB)
IndoleacetateMetaboliteHMDB0000197 (HMDB)
IsoleucineMetaboliteHMDB0000172 (HMDB)
Isovaleryl-CoAMetaboliteHMDB0001113 (HMDB)
LARS2GeneProductENSG00000011376 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973
LDHAGeneProductENSG00000134333 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759
LactateMetaboliteHMDB0000190 (HMDB)
Leu-tRNAMetaboliteCHEBI:16624 (ChEBI)
LeucineMetaboliteHMDB0000687 (HMDB)
MAOAGeneProductENSG00000189221 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915
MARS2GeneProductENSG00000247626 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136
MCCC1GeneProductENSG00000078070 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289
MDH1GeneProductENSG00000014641 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051
MDH2GeneProductENSG00000146701 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050
MPSTGeneProductENSG00000128309 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733
MUTGeneProductENSG00000146085 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239
MalateMetaboliteHMDB0000156 (HMDB)
MelaninMetaboliteHMDB0004068 (HMDB)
Met-tRNAMetaboliteCHEBI:16635 (ChEBI)
MethionineMetaboliteHMDB0000696 (HMDB)
Methyl-OH-butyryl-CoAMetaboliteHMDB0001356 (HMDB)
Methylacetoacetyl-CoAMetabolite15476 (ChEBI)
Methylbutyryl-CoAMetaboliteHMDB0001041 (HMDB)
Methylcrotonyl-CoAMetaboliteHMDB0001493 (HMDB)
Methylglutaconyl-CoAMetaboliteHMDB0001057 (HMDB)
N-FormylkynurenineMetaboliteHMDB0001200 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
OATGeneProductENSG00000065154 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394
ODC1GeneProductENSG00000115758 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402
OGDHGeneProductENSG00000105953 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293
OH-indole acetaldehydeMetabolite50157 (ChEBI)
OH-indoleacetateMetaboliteHMDB0000763 (HMDB)
OH-isobutyrateMetaboliteCHEBI:19641 (ChEBI)
OH-isobutyryl-CoAMetaboliteHMDB0001052 (HMDB)
OH-isovaleryl-CoAMetabolite28291 (ChEBI)
OH-methylglutaryl-CoAMetaboliteHMDB0001375 (HMDB)
OH-phenylpyruvateMetabolite
OTCGeneProductENSG00000036473 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448
OrnithineMetaboliteHMDB0000214 (HMDB)
Ox. glutathioneMetaboliteHMDB0003337 (HMDB)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
OxobutyrateMetaboliteHMDB0000005 (HMDB)
P-enolpyruvateMetaboliteHMDB0000263 (HMDB)
P4HA2GeneProductENSG00000072682 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286
PCGeneProductENSG00000173599 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520
PCK1GeneProductENSG00000124253 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501
PDHA1GeneProductENSG00000131828 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775
PDHXGeneProductENSG00000110435 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627
PDK4GeneProductENSG00000004799 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481
PKMGeneProductENSG00000067225 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591
PNMTGeneProductENSG00000141744 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724
PPM1LGeneProductENSG00000163590 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577
PYCR1GeneProductENSG00000183010 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795
Phe-tRNAMetaboliteCHEBI:29153 (ChEBI)
PhenylalanineMetaboliteHMDB0000159 (HMDB)
ProlineMetaboliteHMDB0000162 (HMDB)
Propionyl-CoAMetaboliteHMDB0001275 (HMDB)
PutrescineMetaboliteHMDB0001414 (HMDB)
PyruvateMetaboliteHMDB0000243 (HMDB)
R-S-glutathioneMetaboliteCHEBI:17021 (ChEBI)
RARSGeneProductENSG00000113643 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297
Red. GlutathioneMetaboliteHMDB0000125 (HMDB)
SDHAGeneProductENSG00000073578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195
SDSGeneProductENSG00000135094 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270
SMSGeneProductENSG00000102172 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490
SRMGeneProductENSG00000116649 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690
SUCLG1GeneProductENSG00000163541 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234
SerineMetaboliteHMDB0000187 (HMDB)
SerotoninMetaboliteHMDB0000259 (HMDB)
SpermidineMetaboliteHMDB0001257 (HMDB)
SpermineMetaboliteHMDB0001256 (HMDB)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
TATGeneProductENSG00000198650 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487
TCA cyclePathway
TDO2GeneProductENSG00000151790 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486
THGeneProductENSG00000180176 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735
TPH1GeneProductENSG00000129167 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796
TPOGeneProductENSG00000115705 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813
ThreonineMetaboliteHMDB0000167 (HMDB)
ThyroxineMetaboliteHMDB0000248 (HMDB)
Tiglyl-CoAMetaboliteHMDB0002054 (HMDB)
Trp-tRNAMetaboliteCHEBI:29159 (ChEBI)
TryptamineMetaboliteHMDB0000303 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Tyr-tRNAMetaboliteCHEBI:29161 (ChEBI)
TyrosineMetaboliteHMDB0000158 (HMDB)
UreaMetaboliteHMDB0000294 (HMDB)
VARSGeneProductENSG00000204394 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675
Val-tRNAMetaboliteCHEBI:29164 (ChEBI)
WARSGeneProductENSG00000140105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630
carbamoyl-PMetaboliteHMDB0001096 (HMDB)
dopaMetabolite
glutamate metabolismPathway
glutamate semialdehydeMetaboliteCHEBI:15757 (ChEBI)
glutamyl-PMetaboliteCHEBI:21314 (ChEBI)
glutamyl-cysteineMetaboliteCHEBI:17515 (ChEBI)
glycolysis & gluconeogenesisPathwayWP157 (WikiPathways)
homogentisateMetaboliteCHEBI:16169 (ChEBI)
hydroxy-prolineMetaboliteHMDB0000725 (HMDB)
indole-pyruvateMetabolite
isobutyryl-CoAMetaboliteCHEBI:15479 (ChEBI)
isocitrateMetaboliteHMDB0000193 (HMDB)
mercaptopyruvateMetaboliteHMDB0001368 (HMDB)
methacrylyl-CoAMetaboliteCHEBI:27754 (ChEBI)
methylhistamineMetaboliteHMDB0000898 (HMDB)
methylmalonate semialdehydeMetaboliteCHEBI:16256 (ChEBI)
methylmalonyl-CoAMetaboliteCHEBI:15465 (ChEBI)
oxo-isocaproateMetaboliteCHEBI:17865 (ChEBI)
oxo-isovalerateMetaboliteCHEBI:11851 (ChEBI)
oxo-methyl-valerate MetaboliteCHEBI:35146 (ChEBI)
phenylpyruvateMetabolite
pyrroline carboxylateMetaboliteHMDB0006875 (HMDB)
pyruvate metabolismPathway
urea cyclePathway
valineMetaboliteHMDB0000883 (HMDB)
vanillyl mandelateMetabolite

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP3925"
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