Hallmark of cancer: metastasis and epithelial-to-mesenchymal transition (Homo sapiens)

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Description

Epithelial-to-mesenchymal transition (EMT) is a hallmark of cancer metastasis. EMT is a process that allows epithelial cells to lose their epithelial characteristics and gain mesenchymal features, which makes them more invasive and migratory. This process is a key part of tumor progression and metastasis. EMT gives cancer cells stem-cell properties and makes them resistant to chemotherapy drugs

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
141972view16:30, 28 November 2025EweitzUse gene symbol
135726view22:40, 31 October 2024AlexanderPicoModified description
135725view22:40, 31 October 2024AlexanderPicoModified description
133259view10:02, 10 June 2024PhilipErnst
130165view19:08, 26 May 2024PhilipErnstrecolouring
130161view18:27, 26 May 2024PhilipErnstcleaned up the lines, made sure everything is same width and length
129590view03:34, 16 May 2024EweitzModified title
129579view12:39, 14 May 2024Marvin M2Ontology Term : 'cancer pathway' added !
129578view12:19, 14 May 2024Marvin M2Modified title
129577view11:28, 14 May 2024PhilipErnstNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Asparagine
BrachyuryGeneProductENSG00000250079 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl) CDH1 Promoter is inhibited
Claudins
E-Cadherin
E47GeneProductENST00000696259 (Ensembl)
EC1/2
EHMT2GeneProductENSG00000227333 (Ensembl)
ELF3GeneProductENSG00000163435 (Ensembl)
ELF5GeneProductENSG00000135374 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
GRHL2GeneProductENSG00000083307 (Ensembl)
GSC2GeneProductENSG00000063515 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
Hypoxia
KLF8GeneProductENSG00000102349 (Ensembl)
LSD1/KDM1AGeneProductENSG00000004487 (Ensembl)
PRRX1GeneProductENSG00000116132 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SIX1GeneProductENSG00000126778 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SUV39H1GeneProductENSG00000101945 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
TCF4/E2-2GeneProductENSG00000196628 (Ensembl)
TGF-βGeneProductENSG00000105329 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)
ZEB1GeneProductENSG00000148516 (Ensembl)
ZEB2GeneProductENSG00000169554 (Ensembl)

Annotated Interactions

No annotated interactions

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