Rotenone metabolism (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Caboni P, Sherer TB, Zhang N, Taylor G, Na HM, Greenamyre JT, Casida JE; ''Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.''; Chem Res Toxicol, 2004 PubMed Europe PMC Scholia
2. Innos J, Hickey MA; ''Using Rotenone to Model Parkinson's Disease in Mice: A Review of the Role of Pharmacokinetics.''; Chem Res Toxicol, 2021 PubMed Europe PMC Scholia
3. Fukami JI, Yamamoto I, Casida JE; ''Metabolism of rotenone in vitro by tissue homogenates from mammals and insects.''; Science, 1967 PubMed Europe PMC Scholia
4. ''Oxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicity''; Journal of Agricultural and Food Chemistry, 1969 DOI Scholia

History

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Compare	Revision	Action	Time	User	Comment
	135319	view	07:06, 20 August 2024	Egonw	Modified description
	135044	view	14:54, 1 August 2024	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	135043	view	14:54, 1 August 2024	Egonw	Modified description
	135042	view	14:49, 1 August 2024	Egonw	Added the missing info for the DOI
	135041	view	14:46, 1 August 2024	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
8′-hydroxyrotenone	Metabolite	92207 (PubChem-compound)
CYP2C19	GeneProduct	ENSG00000165841 (Ensembl)
CYP3A4	GeneProduct	ENSG00000160868 (Ensembl)
rotenolone I	Metabolite	68184 (PubChem-compound)
rotenolone II	Metabolite	99189 (PubChem-compound)
rotenone	Metabolite	Q412388 (Wikidata)

Annotated Interactions

No annotated interactions