Renin-angiotensin-aldosterone system (RAAS) (Homo sapiens)

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655CYP21A2ITPR1STARCALML3Corticosterone11-DeoxycorticosteroneAGTR1 inhibitorCALML6CALML5GNAQProgesteroneACECYP11A1ACE inhibitorCALM1Ca2+Angiotensin ICALM3CYP11B2PregnenoloneAGTCholesterolCMA1ITPR3IP3ITPR2ATF6BRENCAMK1DCTSGHSD3B2PLCB2CALML4CALM2HSD3B118-HydroxycorticosteroneAngiotensin II36AGTR25AGTR1Aldosterone1Molecular initiating events66CAMK1GCAMK4CAMK2ACAMK2BCAMK2DCAMK2GCAMK1ATF2ATF1CREB5CREB3L4CREB3L3CREB3L2CREB3L1CREB3CREB1ATF4


Description

The pathway leading angiotensinogen to aldosterone

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.''; Am J Pharmacogenomics, 2004 PubMed Europe PMC Scholia
  2. Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?''; Clin Ther, 2007 PubMed Europe PMC Scholia
  3. Williams GH; ''Aldosterone biosynthesis, regulation, andclassical mechanism of action.''; Heart Fail Rev, 2005 PubMed Europe PMC Scholia
  4. Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?''; Expert Opin Pharmacother, 2007 PubMed Europe PMC Scholia
  5. Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC Scholia
  6. McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.''; BMJ, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139939view09:24, 12 July 2025EgonwCalcium ion with unicode
134891view21:05, 28 July 2024EweitzRefine graphical spacing
134890view21:04, 28 July 2024EweitzRefine graphical spacing
134889view21:03, 28 July 2024EweitzEconomize layout, mitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134888view21:02, 28 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134887view21:02, 28 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134886view21:01, 28 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134885view21:00, 28 July 2024EweitzStandardize case, Mitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134884view20:59, 28 July 2024EweitzStandardize case, Mitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134883view20:56, 28 July 2024EweitzRefine line types: straight -> elbow, for economy and clarity
134882view20:50, 28 July 2024EweitzEconomize layout, tailor node widths, standardize case
134881view20:45, 28 July 2024EweitzImprove node alignment, economize layout
134880view20:36, 28 July 2024EweitzEconomize layout
127761view09:32, 3 December 2023EgonwChEBI id for Ca2+ instead of the "Ca" atom
120634view21:13, 21 December 2021EweitzStandardize node size where applicable
116623view11:08, 9 May 2021EweitzModified title
108364view19:52, 12 December 2019OzanozisikAGTR1 Inhibitor contained ACE Inhibitor information, deleted that.
108230view20:47, 29 November 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
108227view13:29, 29 November 2019OzanozisikModified description
108226view13:28, 29 November 2019Marvin M2Ontology Term : 'renin-angiotensin cascade pathway' added !
108225view13:28, 29 November 2019Marvin M2Ontology Term : 'aldosterone biosynthetic pathway' added !
108223view13:24, 29 November 2019OzanozisikNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-DeoxycorticosteroneMetaboliteCHEBI:16973 (ChEBI)
18-HydroxycorticosteroneMetaboliteCHEBI:16485 (ChEBI)
ACE inhibitorMetaboliteCHEBI:35457 (ChEBI)
ACEGeneProduct1636 (Entrez Gene)
AGTGeneProduct183 (Entrez Gene)
AGTR1 inhibitorMetabolite
AGTR1GeneProduct185 (Entrez Gene)
AGTR2GeneProduct186 (Entrez Gene)
ATF1GeneProductATF1 (HGNC)
ATF2GeneProductATF2 (HGNC)
ATF4GeneProductATF4 (HGNC)
ATF6BGeneProductATF6B (HGNC)
AldosteroneMetaboliteHMDB0000037 (HMDB)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
CALM1GeneProductCALM1 (HGNC)
CALM2GeneProductCALM2 (HGNC)
CALM3GeneProductCALM3 (HGNC)
CALML3GeneProductCALML3 (HGNC)
CALML4GeneProductCALML4 (HGNC)
CALML5GeneProductCALML5 (HGNC)
CALML6GeneProductCALML6 (HGNC)
CAMK1GeneProductCAMK1 (HGNC)
CAMK1DGeneProductCAMK1D (HGNC)
CAMK1GGeneProductCAMK1G (HGNC)
CAMK2AGeneProductCAMK2A (HGNC)
CAMK2BGeneProductCAMK2B (HGNC)
CAMK2DGeneProductCAMK2D (HGNC)
CAMK2GGeneProductCAMK2G (HGNC)
CAMK4GeneProductCAMK4 (HGNC)
CMA1GeneProduct1215 (Entrez Gene)
CREB1GeneProductCREB1 (HGNC)
CREB3GeneProductCREB3 (HGNC)
CREB3L1GeneProductCREB3L1 (HGNC)
CREB3L2GeneProductCREB3L2 (HGNC)
CREB3L3GeneProductCREB3L3 (HGNC)
CREB3L4GeneProductCREB3L4 (HGNC)
CREB5GeneProductCREB5 (HGNC)
CTSGGeneProduct1511 (Entrez Gene)
CYP11A1GeneProductCYP11A1 (HGNC)
CYP11B2GeneProductCYP11B2 (HGNC)
CYP21A2GeneProductCYP21A2 (HGNC)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CholesterolMetaboliteCHEBI:16113 (ChEBI)
CorticosteroneMetaboliteCHEBI:16827 (ChEBI)
GNAQGeneProductGNAQ (HGNC)
HSD3B1GeneProductHSD3B1 (HGNC)
HSD3B2GeneProductHSD3B2 (HGNC)
IP3MetaboliteCHEBI:16595 (ChEBI)
ITPR1GeneProductITPR1 (HGNC)
ITPR2GeneProductITPR2 (HGNC)
ITPR3GeneProductITPR3 (HGNC)
PLCB2GeneProductPLCB2 (HGNC)
PregnenoloneMetaboliteCHEBI:16581 (ChEBI)
ProgesteroneMetaboliteCHEBI:17026 (ChEBI)
RENGeneProduct5972 (Entrez Gene)
STARProteinSTAR (HGNC)

Annotated Interactions

No annotated interactions

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